Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure
...already in nature, but for which we don’t have the tools yet that nature has.?/p> The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of fu...Space matters: Estimating species diversity in the fossil record
...rsity crisis. Thanks to the innovative text-mining tools and approach presented here, future studies can more easily correct for area effects and explore these issues. And given the parallels between species-area relationships in paleontology and ecology, collaborations across disciplines may offer valuabl...Stem cell training program to make its Stanford debut
...already in nature, but for which we don’t have the tools yet that nature has.?/p> The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of fu...NIH creates nationwide network of molecular libraries screening centers
...so referred to as small molecules, can be valuable tools for understanding the many important cellular even... should provide researchers with many new chemical tools to explore how cells function at the molecular level." "This collaborative screening effort will en...Carnegie Mellon University research reveals how cells process large genes
... distant exons. Lopez's team developed molecular tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he found that the production of recursive lariats greatly exceeded that of direct lariats, indicating that recursive splicing is the predominant processing path...Reversal of role for a viral protein associated with the development of lymphoma
... distant exons. Lopez's team developed molecular tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he found that the production of recursive lariats greatly exceeded that of direct lariats, indicating that recursive splicing is the predominant processing path...Temperature regulates circadian clock in zebrafish
...ycles. Zebrafish cell lines also proved valuable tools for studying temperature response, showing a similar pattern of clock gene expression during cycles of small temperature changes and continued entrainment of clock gene expression even after the cells were exposed to constant temperature. Acute tempe...VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
... or metastasize, we would be able to design better tools to help treat cancers," said lead author Sarah Spiegel, Ph.D., chair and professor in the VCU Department of Biochemistry and co-leader of the Massey Cancer Center Cell Signaling program. Spiegel, who is internationally recognized for her pioneering...Molecular miners find pain relief drugs from the sea
... the number of cone snails required to develop new tools and therapies for medical research and therefore minimise the environmental impact of the research. "With a single cone snail we can create and store large libraries of conotoxin genes." It was using this genetic mining technique that ACV1 was disco...MERIS monitoring tracks planetary photosynthesis levels
...-JRC. "It requires the development of mathematical tools to minimise the effects due to scattering from atmospheric particles, the presence of soils and the changing geometry of illumination and observation." The validation of MGVI is in fact an ongoing activity, along with that for a family of related ...Researchers predict infinite genomes
...to a startling conclusion. Armed with the powerful tools of comparative genomics and mathematics, TIGR scientists have concluded that researchers might never fully describe some bacteria and viruses--because their genomes are infinite. Sequence one strain of the species, and scientists will find significan...Microbe has huge role in ocean life, carbon cycle
...bes, gene cloning, sequencing techniques and other tools have been used in this exploration. ...Researchers identify genes associated with lung transplant rejection
... compromise the immune system, which are the major tools currently available to fight lung rejection. Co-authors of the study were Xiang Xu, MD, PhD, Jeffrey A. Golden, MD, Gregory Dolganov, PhD, Kirk D. Jones, MD, Samantha Donnelly, PhD, and Timothy Weaver, Bsc, all of UCSF. ...Hunt for human genes involved in cell division under way
...earch and these partners have provided us with the tools to carry out this search," says Ellenberg. "Thousands of genes have been tested in the initial phase of the project and the results are very promising." The systematic search and analysis of the screen is set to be completed by the end of 2005. ...Unweaving amyloid fibers to solve prion puzzles
...e, he instead used a combination of low resolution tools to analyze varieties of prion strains and piece together the puzzle of how amyloids form. "We now have an overall picture of how prions join together to form the amyloid's molecular structure," says Lindquist, who also is a professor of biology at M...Clearing jams in copy machinery
Bacteria and humans use a number of tools to direct perhaps the most important function in cells -- the accurate copying of DNA during cell division. New research published this week in Molecular Cell from the laboratory of Rockefeller University's Michael O'Donnell, a Howard Hughes Medical ...Long-sought flower-inducing molecule found
... This knowledge can lead to the development of new tools that can be used to control the timing of plant flowering, something that is of central importance in both agriculture and forestry. We are all familiar with the fact that different plants flower at different times of the year. Daffodils in spring, ...UCLA scientists reveal how Nipah virus infects cells
... University of Pennsylvania, the UCLA team applied tools of advanced molecular biology as well as old-fashioned detective work to track down the identity of the Ephrin-B2 receptor. The researchers created a bait: they stitched the Nipah protein to part of a human antibody, like a worm on a fishing hook. W...New NIAID grants strengthen national biodefense and emerging infectious diseases research network
... and create preventive, therapeutic and diagnostic tools that will leave us far less vulnerable." NIAID es...ext-generation treatments, vaccines and diagnostic tools for diseases such as anthrax, plague, smallpox, tularemia, botulism and West Nile fever. University......ion NIGMS pilot program to develop new methods and tools to streamline and speed many of the laborious steps involved in generating protein structures. The researchers applied the new technologies to determining three-dimensional structures of approximately 200 proteins, representative of some of the 100,0...