Chemical switch triggers critical cell activities
...d into the docking site at that point, it would be too far away from NEDD8 to grab it, she noted. And that was the puzzle the St. Jude researchers solved. Specifically, the St. Jude study showed that when NEDD8 forms a thioester bond with E1's left hand, it squeezes itself next to the E2 docking site...Custom-made cancer cell attacks
...ltivating corn to use only its grain would take up too much land. According to the National Environmental Trust, producing 35 billion gallons of ethanol annually would require putting an additional 129,000 square miles of farmland-an area roughly the combined size of Kansas and Iowa-into corn production....Some caterpillers just don't want to grow up
...e currently available data, the effect seems to be too weak to fully explain the large proportion of caterpillars delaying development. Based on a simple model expansion, the scientists predict that added benefits achieved by slow-developers after emergence would also tip the balance in favor of slow dev...Cellulosic ethanol: Fuel of the future?
...ltivating corn to use only its grain would take up too much land. According to the National Environmental Trust, producing 35 billion gallons of ethanol annually would require putting an additional 129,000 square miles of farmland-an area roughly the combined size of Kansas and Iowa-into corn production....Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer
... some encouraging data. The number of patients is too small to draw any definite conclusions, however," Lu said. Three patients of eight who received two or more doses experienced stable disease for three to seven months. Median survival time for all patients is 14.6 months, which Lu notes compare...Birth rate, competition are major players in hominid extinctions
...es that competition from modern humans was already too strong. The environment was marginal and modern humans were already foraging and small-animal collecting. "I think they were out-competed at the very end," says Jablonski. "Modern humans simply did it better, more nimbly." She adds that mode...Speeding 'fingertip' discovery -- 20 years of protein info in 1 place
...n intact. Previous spectrometry methods were “just too rough?on the delicate protein alterations and shea...s been able to get a handle on because they’re way too hard to work with. Now we have the tools to probe further,?he says. ...Prehistoric mystery organism verified as giant fungus
...elephants that came much later, they probably grew too slowly to rebuild from regular disturbances of any kind, Boyce said. "It’s hard to imagine these things surviving in the modern world," he said.......cking, it has a profound effect on flies. However, too much does not cause tumor growth. Choi is also a faculty member of the BCM Graduate School of Biomedical Sciences. ...Bumblebee house warming -- it takes a village
...wings to cool the nest when the temperature became too hot. Performance of various in-nest tasks is no... researchers did not want to raise the temperature too high. Excessive heat can kill bumblebees. In looking at the incubation behavior, O'Donnell said wor...Scientists unravel clue in cortisol production
...term exposure, while impairing learning if there's too much for too long. Given the variety of its effects,understanding how cortisol is made is essential to producing ...Meeting the ethanol challenge: Scientists use supercomputer to target cellulose bottleneck
...g a curveball. In real-life the process occurs far too quickly to evaluate visually, but by using the supercomputer simulations to break the throw down into a step-by-step process, the scientists can see the precise details of the role of velocity, trajectory, movement, and arm angle. To undertake the la...Targeting tumors the natural way
...s on cancer cells usually reside on healthy cells, too - albeit in lower numbers - therapies aimed at these receptors are always expected to have debilitating side effects. That's why Kiessling's approach holds such promise. "What we've shown is that you don't need a receptor that's found solely on tum...Short chromosomes put cancer cells in forced rest
... divides and eventually - when the chromosomes get too short - force the cell to essentially commit suicide. Such cell death is natural, and when it fails to happen, the result may be unbridled cell growth, or cancer. The first generation pups born to these mice contained no telomerase and very long ...'Terror bird' arrived in North America before land bridge, study finds
...ssess the age of fossil bones directly as they are too old to be carbon dated," Trueman wrote in an e-mail. "Bones can also be moved after death, further confusing their true age. MacFadden's approach compares bones of disputed age with those of known age. If the chemistry matches, the bones are of the s...A revolution in the monitoring of unborn babies
...at they are running into difficulties before it is too late to help them. This may involve urgent delivery of the fetus.? The device will be especially helpful in monitoring fetuses whose mothers have medical conditions like diabetes, autoimmune conditions such as systemic lupus erythematosus and Sjogr...Reactivated gene shrinks tumors
...drugs that restore p53 and you don't have to worry too much about toxic side effects," said Ventura. Possible therapeutic approaches to turn on p53 in human cancer cells include small molecules that restore mutated p53 proteins to a functional state, as well as gene therapy techniques that introduce a...Chemicals in brown algae may protect against skin cancer
... seaweed may protect against skin cancer caused by too much sun, new research suggests. The animal study indicates that chemicals called brown algae polyphenols (BAPs), which are found in a type of brown marine seaweed, might protect against skin cancers caused by ultraviolet B (UVB) radiation. UVB...Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows
...ast, it’s thought that Down syndrome patients have too much GABA-related inhibition, making it difficult ...s any overenthusiastic college student can attest, too much caffeine can backfire. The same is true with high doses of PTZ, which can cause seizures. In fa......an lead to unwanted side effects or doses that are too weak to provide effective treatment. __IMAGE_2 "Mucus barriers evolved to serve a helpful purpose: to keep things out," said Justin Hanes, an associate professor of chemical and biomolecular engineering who supervised the research. "But if yo...