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Tag: "tolerated" at biology news

Africa's first large-scale HIV vaccine study launches

...ith this vaccine suggest that it is generally well tolerated and that the response of the immune system or immunogenicity is high. In South Africa, the vaccine trial is called "Phambili," which means "moving forward" in the Xhosa language. Volunteers will be healthy HIV negative males and females, aged 18...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...disease. The clinical trial continues. No maximum tolerated dose has been established, Lu says. The nanoparticle delivery system consists of a plasmid gene expression cassette loaded with DNA that encodes the FUS1 protein. This is wrapped tightly in a form of cholesterol to protect it from the body's def...

An artificial cornea is in sight, thanks to biomimetic hydrogels

...or biocompatibility in animal models. Animals have tolerated artificial corneas with no problems in trials as long as eight weeks, Ta says. The material remains perfectly clear, he says. Longer trials are a next step. The current source of tissue for corneal transplants is cadavers. Donor tissue has problems...

Too mellow for our predatory world

...ne iguanas with no experience of predator-pressure tolerated a human approach up to one or two metres and failed to mount a stress response even during sustained chasing. Darwin had already described the remarkable tameness of these animals, also termed "low wariness", during his voyage on the Beagle in 1835. ...

Pilot study successful in taming allergic reactions to food

...givers a supply of egg product, allocated into the tolerated doses, which the subjects consumed daily at home, mixed with other foods. The children returned to the clinic every two weeks. At each visit, the researchers increased the subjects?dosages until they reached the equivalent of one-tenth of an egg,...

Study of gene transfer for erectile dysfunction shows promise

...n the small pilot study, this new therapy was well tolerated and safe," said George Christ, Ph.D., senior researcher and a professor at the Institute for Regenerative Medicine at Wake Forest University School of Medicine. "It provides evidence that gene transfer is a viable approach to treating ED and other di...

Gene therapy injected into the brains' of mice with Huntington's disease

...cal Center, which was reported to be safe and well tolerated in PD patients at the American Association of Neurology meeting last spring. Initial efficacy results of this Phase I trial are expected to be presented this fall and a double-blinded, controlled Phase II trail in PD patients is planned for later th...

Radiotherapy advance points way to noninvasive brain cancer treatment

...the tumor and radiation treatment with the maximum tolerated dose - all of which leads to a painfully low quality of life. Because of this, researchers are racing to find better therapies to stop or slow GBM. In the Jan. 1, 2006 issue of the journal Clinical Cancer Research, Gelsomina "Pupa" De Stasio, profes...

Gene variation increases SIDS risk in African Americans

...-- such as a long pause in respiration -- that are tolerated by children without the mutation." "The hope," he added, "is that findings like this may one day allow us to intervene. We might screen to identify children at high risk and teach parents how to lessen the likelihood of secondary challenges. We h...

Basic research leads to a novel cancer therapy

...ancer cell functions in multiple ways and are well tolerated by patients." This is the second time that Ullrich has played a leading role in the development of a successful cancer therapy. Seven years ago, his research led the breast-cancer therapy Herceptin® to be brought to the market by Genentech. In contr...

Scientists look to the Bahamas as a model for coral reef conservation

...be beneficial to the host and that is why they are tolerated by the immune system." It's an intriguing idea that requires more research in animal models. "We don't know what to look for per se," he said. "But we can guess that since a persistently infected host is constantly having its immune system stimulate...

Learning to love bacteria: Stanford scientist highlights bugs' benefits

...be beneficial to the host and that is why they are tolerated by the immune system." It's an intriguing idea that requires more research in animal models. "We don't know what to look for per se," he said. "But we can guess that since a persistently infected host is constantly having its immune system stimulate...

Compound from marine bacteria shows potential as multiple myeloma therapy

...ive than using either therapy alone ?and be better tolerated by patients as well. In preclinical studies, NPI-0052 blocks a wider range of proteasome activities than bortezomib, say the researchers, and works at lower doses. NPI-0052 also appears to be less toxic to normal cells. Bortezomib is currently gi...

Ophthalmologists implant five patients with artificial silicon retina microchip

...otoreceptor cells of the retina. If the implant is tolerated well and is able to successfully stimulate the retina, it may open up new opportunities for restoring sight in patients with the end stages of retinitis pigmentosa." ...

Ophthalmologists Use Artificial Silicon Retina Microchip To Treat Vision Loss

...otoreceptor cells of the retina. If the implant is tolerated well and is able to successfully stimulate the retina, it may open up new opportunities for restoring sight in patients with the end stages of retinitis pigmentosa." ...

Color-blind method opens new doors in DNA sequencing

... precision, and the number of mistakes that can be tolerated is extremely low," said Curl, University Professor, the Kenneth S. Pitzer-Schlumberger Professor of Natural Sciences and professor of chemistry. "Our new method does away with identification problems altogether, because the imaging is very clean." M...

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