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Tag: "tissues" at biology news

Study: 'homemade' gene expression technology unreliable

...derived from mouse livers and the other taken from tissues of several mouse organs. According to the study, reproducibility between platforms and across laboratories was generally poor, but reproducibility between laboratories dramatically increased to acceptable levels when a commercial microarray was used...

New tumor-suppressor gene discovered

...ell proliferation and promoting cell death, so the tissues get much smaller." Lai's lab also performed other experiments that demonstrated that the two protein products of the two genes join structurally at the molecular level to form a larger, more powerful, and more productive protein complex. Because of ...

Scientists discover that three overlapping signals in embryo help get the backbone right

...in, into the belly of an embryo caused surrounding tissues to develop into structures normally found on the b...e embryo. "When we removed these signals, all the tissues that form on the back of the embryo - brain, spinal cord and muscles - were lost," Khokha said. "Not...

Compounds in plastic packaging act as environmental estrogens altering breast genes

...BPA changes the gene expression profile of mammary tissues as a function of age. That is, there was a significant increase in protein production governed by various genes at increasing ages from 21 to 100 days." These included proteins regulating cell proliferation and differentiation, including tumor-suppr...

UCSD research reveals mechanism involved with type of fatal epilepsy

...mulation of starch-/glycogen-like granules in most tissues of Lafora disease patients. Thus, researchers have long thought that a defect in glycogen metabolism is intimately linked to the disease. Recessive mutations in two genes have been shown to cause Lafora disease. The genes encode the proteins laforin ...

Doctors closer to using gene analysis to help trauma patients

... personnel sampled whole blood and other available tissues from more than 200 severely traumatized or burned patients and 23 healthy individuals in an effort to correlate molecular markers with white blood cell behavior, and ultimately, with patient outcome. Studies in healthy patients were conducted at UF, ...

Protein prevents detrimental immune effects of bacterial sepsis

...ts toxins actually causes damage to the host's own tissues when it goes into overdrive, releasing too many immune signals. Thus, the immune response must be carefully controlled to prevent damage to the host. Damazo et al. studied this balancing act by analyzing the effects of the bacterial toxin LPS on nor...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...ents with human breast cancer cell lines and tumor tissues of human xenograft model. "This provides solid preclinical evidence that we can use toward development of a novel device that can measure CDK activity in human tissue within several hours," Ueno says. He adds that a clinical trial is currently under...

Signs of aging: Scientists evaluate genes associated with longevity

...pathways contribute to the deterioration of cells, tissues and organisms during aging." In an effort to perform a comprehensive analysis of gerontology-related genes, the researchers compared gene-expression libraries obtained from daf-2 mutants to those obtained from controls at different ages. They predic...

Findings have implications for tracking disease, drugs at the molecular level

...ly used for multiphoton imaging, in which specific tissues or cells -- cancer cells, for example -- are fluor...e way for being able to observe behavior in living tissues at the single molecule level," said Fourkas. "The fluorescent molecules commonly used in multiphoton...

Cellular Defects in Premature Aging Disease are Reversible

...of cell division, bolsters this possibility. "Some tissues in our body do not divide," Misteli pointed out. "So demonstrating that we can rescue the normal phenotype without cell division means this procedure could be effective in all tissues." Misteli and his group will also look more closely at healthy cel...

New polysaccharide may help combat multidrug resistance in cancer

...ronan as a structural and inert molecule. In adult tissues it plays two roles. First, it assists in tissue hydration and in biophysical properties such as resilience. Second, it forms a template to which matrix proteins attach and form important extracellular structural complexes." Hyaluronan also accumulat...

Of mice and men's (and women's) contraceptives

... it can't be a protein also active in such somatic tissues as brain, heart, liver, and so forth, only in the reproductive cells we want to target." Investigating germ cell molecules for contraception is also desirable because it frequently allows reversibility. Hecht and colleagues have been proposing this ...

Breakthrough isolating embryo-quality stem cells from blood

...which have not yet differentiated into specialised tissues such as skin, brain or muscle. They promise a new class of regenerative medicine, which could repair apparently permanent damage such as heart disease or Parkinson's. The cells are currently taken from aborted human foetuses, an issue which has led t...

Future diabetes drugs may target new protein interaction

...cularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicine. Authors on the paper are Rodgers, Puigse...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...cularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicine. Authors on the paper are Rodgers, Puigse...

Computational verification of protein-protein interactions by orthologous co-expression

...cularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicine. Authors on the paper are Rodgers, Puigse...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...cularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundation, the American Federation for Aging Research, and start-up funds from the Department of Cell Biology at the Johns Hopkins School of Medicine. Authors on the paper are Rodgers, Puigse...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

...elta T cells migrate from the thymus to epithelial tissues such as skin and the linings of the lung. While their precise role remains poorly understood, they perform vital protective functions. Certain lung infections easily cleared from normal laboratory mice are a death sentence for those lacking gamma-del...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...ion would reject the transplants. Instead, the new tissues engrafted with little difficulty, curing the rats ...nstructor in medicine, harvested the embryonic pig tissues at precisely the right point in their development. "When we again harvested the transplant tissues ...

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