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Tag: "thousands" at biology news

Probing The Promise And Perils Of Nanoparticles

...own as dendrimers, tiny spheres whose width is ten thousands times smaller than the thickness of a human hair. Dendrimers have shown promise for precisely delivering drugs to their targets inside the body, but high concentrations of these nanoparticles can be toxic. In earlier work, U-M researchers discovered ...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...mal, the vector directs the animal’s cells to make thousands ofcopies of the HER2/neu growth protein, says Lachman.In addition, the VRP-neu preferentially homes to specialized immunesystem cells known as dendritic cells, and infects them. Inside,VRP-neu produces high levels of the HER2/neu protein, which thede...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

...mal, the vector directs the animal’s cells to make thousands ofcopies of the HER2/neu growth protein, says Lachman.In addition, the VRP-neu preferentially homes to specialized immunesystem cells known as dendritic cells, and infects them. Inside,VRP-neu produces high levels of the HER2/neu protein, which thede...

Alcohol's effects on gene expression in the central nervous system

...ination of a small glass microscope slide that has thousands of different DNA samples attached to it ?that are applied to brain function are just beginning in the field of alcoholism. Several years ago, it was impossible to analyze more than a handful of these genes, however, microarray technology has changed ...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...tochastic event simulator, which keeps trackof the thousands of complex species formed from pathway proteins as...dvantage of the power of computers to generate the thousands ofpotential protein complexes and reactions that cells are able togenerate.The Molecular Sciences In...

The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures

...example, a robotic arm drops protein solution into thousands of tiny wells for crystallization trials, and an imaging system quickly scans the wells looking for signs of crystal formation ?key to capturing protein structures. “At this large scale, it would be unthinkable to do all these steps by hand,?said Jo...

Tiny scaffolding allows stem cells to become working fat cells

...us shortage of transplantable organs available for thousands of patients nationally," Kniss said. "One ultimate goal of this work might be creating new tissue that could serve either as a temporary substitute while waiting for a donor organ, or even providing a replacement organ." Along with Xihai Kang and Yu...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

...s. That repository contains the results of tens of thousands of laboratory measurements of physical interactions of proteins in more than 100 species. Ideker and his colleagues developed a computerized tool called PathBLAST to search through the Database of Interacting Proteins for protein interactions that ar...

South America's vast pantanal wetland may become next everglades, UNU experts warn

...allow lake the rest, creating a unique habitat for thousands of species, many endangered, including more than 650 bird species, over 190 species of mammal, 50 reptiles, more than 1,100 butterfly species and 270 fish species. It is also the wintering grounds for a large number of migratory birds that summer in ...

UF Researchers Map Bacterial Proteins That Cause Tooth Loss

...ontal disease. Now scientists have identified the thousands of proteins the bacterium produces, shedding light on how it interacts with healthy cells in order to thrive, according to dental researchers from the University of Florida and the University of Washington. They describe their findings in the current...

Love at first smell

...s, including humans. Humans have used perfumes for thousands of years. However, it seems that our choice of perfume should depend on our MHC genes. Perhaps these results explain why some perfumes smell good on some people and terrible on others." Professor Thomas Boehm, Max-Plank Society said: "The new result...

In the migratory marathon, parasitized monarchs drop out early

...rch butterflies in eastern North America fly up to thousands of kilometers from Canada to Central Mexico ?one of the longest migrations of any insect species. Emory University researchers found that monarchs infected with a protozoan parasite fly slower, tire out faster and expend more energy flying than healt...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

...of Science. "We have shown that the dispersion of thousands of brightly emissive multi-porphyrin fluorophores within the polymersome membrane can be used to optically image tissue structures deep below the skin ?with the potential to go even deeper," said Michael J. Therien, a professor of chemistry at Penn. ...

Genrate: a generative model that finds and scores new genes and exons in genomic microarray data

... gene structures found by GenRate, each containing thousands of bases from the genome, are confirmed using RT-PCR experiments. ...

Probing the promise and perils of nanoparticles

...own as dendrimers, tiny spheres whose width is ten thousands times smaller than the thickness of a human hair. Dendrimers have shown promise for precisely delivering drugs to their targets inside the body, but high concentrations of these nanoparticles can be toxic. In earlier work, U-M researchers discovered ...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...g is very ineffective. There have been hundreds of thousands of bovine spongiform encephalopathy cases, for example, and lots of people exposed to tainted beef products, but very few cases of variant Creutzfeld-Jakob." He says there "must be protective mechanisms working there, but we don't know what they are...

Computational Method Speeds Mapping of Cell Signaling Networks

...neous activities of several signaling molecules in thousands of individual cells was analyzed using a powerful ...orks. Being able to monitor multiple components in thousands of cells at once was pivotal to the group’s success. Despite technical hurdles, the team believes si...

Navigating an integrated yeast network

...n observed experimentally. A living cell contains thousands of proteins, genes and macromolecules, enmeshed in...ed to different types of cellular networks. "[T]he thousands of physical and functional interactions that exist within all cells can begin to be untangled to pro...

Youth With HIV Take More Risks After New Meds Introduced

...ly lowered virus levels and prolonged the lives of thousands of HIV patients. Although the new study does not prove that the introduction of HAART is the cause of increased risky behavior, "these findings indicate the need for continued attention to the issue of sexual risk and the impact of HAART," Lightfoot...

Medical whistleblowers speak out

... scientist, that "might be associated with tens of thousands of deaths a year" but this risk "would never be detected in studies of the kind that we routinely submit and are the basis for approval. These drugs are essentially out there now, unlabeled, unnoticed, all beneath the radar." Lenzer's account captur...

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