Scientists identify molecular events that drive cell senescence
...d the micewith the mouse form of the amyloid gene, they made lots of antibodieswithout stimulating cytotoxic T cells. When we get to human studies, wehope to show that humans can make human antibodies against the amyloidas well."Current treatments for Alzheimer's disease focus on the symptoms sinceno ther...The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
...pelines in place, the number of protein structures they have solved has increased significantly. In the second, third, and fourth years of the pilot phase, the centers in aggregate reported 109, 217, and 348 structures, respectively. Now, halfway through the fifth year, they’ve surpassed a total of 1,000....New insight into people who 'see' colors in letters and numbers
People with a form of synesthesia in which they see colors when viewing letters and numbers really...onance imaging (fMRI) of their brains reveals that they show activation of color-perception areas. The researchers said their findings lend support to the ...Study Models Impact Of Anthrax Vaccine
...compared to justrapid use of antibiotics. However, they found that if the vaccine is 95percent effective, it could reduce the time that antibiotics would beneeded up to 43 days.An 80 percent effective vaccine could reduce time on antibiotics by upto 23 days. The vaccine could also prevent cases if anantib...The BIOS Initiative - open source biotechnology is born
...technology toolkit. These tools, and the precedent they establish, will allow the public-sector, small to ...w way of visualizing where these genes are and how they function. "These tools are seeding a growing movement ?the BIOS Initiative ?that will enable researc...Beyond lithium for bipolar disorder
... brain slices. They discovered several genes that they concluded "suggest new directions toward the treat... found to be associated with a rat model of mania, they said. This gene codes for a protein that is an "orphan receptor"--that is, its cellular function in ...Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
...tem cells, and how these optical signals change as they differentiate into nerve, muscle, and other tissues. "At present, there's no rapid method for identifying the transitional states [of a stem cell] with the functional cell type it eventually becomes. That process is a mysterious sequence of metabolic...New research indicates a 'troubled' greenhouse is brewing
...s of evidence of past rainfall, but Retallack says they also can be used to determine the seasonality of rainfall as well as the amount of rainfall because the spread within the profile of carbonate nodules is related to the difference in precipitation between the driest and wettest month. Retallack uses ...Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease
...n called amyloid plaque. Such basic understanding, they said, could lead to approaches to preventing plaqu...normal reaction, molecules are free in solution so they interact with each other randomly," Akhremitchev said. "If you want to dissect the process, you woul...Newly Discovered Compound Blocks Known Cancer-Causing Protein
...of one-third of all cancers. The scientists showed they could block the growth of cultured colon cancer ce..." Once the scientists had identified cysmethynil, they worked with Duke chemist Eric Toone and chemistry graduate student David Gooden to synthesize the mo...Simple drug has the potential to save many lives threatened by malaria
...drug, given to children with severe malaria before they reach hospital, has the potential to save many liv...reduce delay has the potential to save many lives, they conclude. http://press.psprings.co.uk/bmj/february/ppr334.pdf">You can read the paper here. ...Tiny scaffolding allows stem cells to become working fat cells
... cells never completely functioned in the same way they do in normal tissue. They failed to produce the ge...s were able to extract RNA from the cells, just as they can from naturally occurring fat cells, and from that proved that the cells expressed the normally e...Plants defy Mendel's inheritance laws, may prompt textbook changes
...." The scientists kept the plants in isolation so they couldn't accidentally crossbreed with plants that ...ects that a number of other genes and the proteins they produce are involved in activating this process. "We need to understand more about the molecular me...Scientists identify new model Of NK cell development
...to the bloodstream and migrate to the thymus where they learn their role. In contrast, B cells, which make...referred to as CD56 bright and CD56 dim cells) and they observed that the bright subset appeared much more frequently in lymph nodes than in bone marrow or ...The very unexpected life and death of a leukemic cell
...he bone marrow grow and survive to the point where they become abnormal and malignant (leukemic). The prog...e disorder where leukemic cells accumulate because they cannot die. Clearly CLL is a disease in which there is a dynamic interplay between rates of cell div...Study of genomic DNA leads to new advances in cancer diagnostics
...pecificity and sensitivity of these methods before they are used in the clinical setting. Physicians and researchers alike know that how a cancer cell interacts with its microenvironment is important for cancer progression. Such interactions must be aberrant for abnormal cell growth and metastasis to occ...White blood cell waste disposal system plays critical regulatory role
...ne marrow and released into the blood stream where they migrate out of the blood and roam the body in sear...ked the ability to migrate into body tissues where they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice receive...New RNA polymerase discovered in plants
...d said. "Plants can get by without Pol IV, whereas they can't do without the other three. We don't see any...evidence that Pol IV is a distinct RNA polymerase, they still have many aspects of Pol IV to unravel. "We know what happens when its gone, but not how it b...Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
... beta-catenin protein in the epithelium layer, yet they do not get cancers. However, combining the Foxl1 deficiency with an inactive APC gene had drastic outcomes. The group compared animals that were partially deficient for APC (containing one normal copy of the APC gene and one mutant inactive copy) in ...NJIT Presidential Award winner takes stem cell research another step
...ctures and other defects that may not heal because they are also suffering from other disorders. We are lo...the right conditions, or given the proper signals, they have the ability to turn into different cell types. Arinzeh is doing exactly that: developing signa...