Purdue proves concept of using nano-materials for drug discovery
...t's been very hard to study these proteins because they are difficult to produce in large quantities," Lee... pores in this membrane are nanometer in scale, so they do not allow proteins to readily pass through the membrane but will allow smaller molecules to pass....Scientists discover the cellular roots of graying hair
...Cancer Institute and Children’s HospitalBoston say they have found the cellular cause of graying hair whil... do the non-specialized stem cells becomedepleted, they also progressively make errors, turning into fullycommitted pigment cells in the wrong place within ...Researchers identify target for cancer drugs
...that when mTOR and rictor bind and form a complex, they help activate Akt by adding a phosphate group to a sequence of its amino acids (a process called "phosphorylation"). This process occurs not only in human cells but in other organisms such as the fruit fly. Finding this complex conserved in species ...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
...Cancer Institute and Children’s HospitalBoston say they have found the cellular cause of graying hair whil... do the non-specialized stem cells becomedepleted, they also progressively make errors, turning into fullycommitted pigment cells in the wrong place within ......Cancer Institute and Children’s HospitalBoston say they have found the cellular cause of graying hair whil... do the non-specialized stem cells becomedepleted, they also progressively make errors, turning into fullycommitted pigment cells in the wrong place within ...Experiments provide proof of how traveling in groups protects insects
...ents involving animals are more dramatic than when they band together and head out on the march cross-coun...iles wide and extend 10 miles or so in length. And they can travel a mile or so a day. Why such groups of insects form has mystified humans for thousands o...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...nature wraps and tags genes determines if and when they become active, according to researchers from Harva...are attached to the spools and switch on the genes they wrap. In most cases, they found these tags turn genes on and off individually. The big surprise invo...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
...on factors.?When these genes are altered, thegenes they control can go awry, causing abnormalities in thed...e mouse that appeared to be transcription factors: they turned up1,445 of them. Next, they determined that more than 1,000 of these TF’swere expressed in th...New research questions basic tenet of neuron function
...tters, both when the neurons were at rest and when they were active. From these observations, as well as data gathered from electrophysiological techniques, the researchers found two distinct types of vesicles. "The functional differences of these two sets of vesicles may be the result of differences in ...Vital step in cellular migration described by UCSD medical researchers
...d and smooth muscle, and neurons. For this reason, they believe the mechanism used by alpha4 integrins to localize Rac activity may participate in a wide variety of cell migratory and pathfinding events. In addition to Nishiya and Ginsberg, additional authors were William B. Kiosses, Ph.D., The Scripps R...U-M scientists find genes that control growth of common skin cancer
...tigators used genetically engineered mice in which they couldmanipulate expression of an Hh pathway component, called Gli2 ,effectively turning it on or off at will in the skin. As expected,expression of Gli2 resulted in BCC formation. In addition, theresearchers found that sustained expression of Gli2 is...Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
...mounts of clathrin," Dr. Ryan explained. However, they faced one methodological roadblock. As Dr. Ryan e... just too blunt an instrument," he said. Instead, they came up with a whole new method of inquiry. It combined two pre-existing technologies -- RNA interfe...Experiments provide proof of how traveling in groups protects insects
...ents involving animals are more dramatic than when they band together and head out on the march cross-coun...iles wide and extend 10 miles or so in length. And they can travel a mile or so a day. Why such groups of insects form has mystified humans for thousands o...New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
...FX) reported today in Science magazine online that they have completed a high-resolution scan of structure...y fifth base, on average, of 10 human chromosomes; they found that thousands of regions of the genome are transcribed into overlapping RNA sequences and tho......e researchers report. Cell culture studies suggest they can reproduce that success in a wide range of othe...too. "What's unique about these analogues is that they do all this without affecting primary tumor cells, or their blood supply," Dr. Huang said. "To our k...Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine
...ildren. “However such vaccines are so complex that they cancarry carbohydrate targets for only a few specific strains of pneumoniabacteria,?Tuomanen said. “So children are always under-protected,since there are so many different strains of these bacteria.?Knowingthe shape of CbpA will guide researchers in...Critical role in programmed cell death identified
...efect die. The researchers demonstrated that when they cause worm mitochondria to fragment without instructing cells to die, the cells still die and when they block fragmentation, the cells survive; in other words, blocking fragmentation prevents cell death, ...New comparative toxicogenomics database
...ildren. “However such vaccines are so complex that they cancarry carbohydrate targets for only a few specific strains of pneumoniabacteria,?Tuomanen said. “So children are always under-protected,since there are so many different strains of these bacteria.?Knowingthe shape of CbpA will guide researchers in...Taking Aim With Nanoparticle PEBBLEs
...isrupting their DNA, PEBBLEs never enter the cells they target. Instead, they attach to the outside of the targeted cell and shoot reactive oxygen species into it, setting off "a...ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors
...ble for the red colors found in the parrot species they sampled. The researchers used a chemical analysis...nt study on the parrot pigments that suggests that they can act as anti-oxidants to quench free radicals and potentially protect cells and tissues in the bo...