Priming embryonic stem cells to fulfill their promise
...ate the daunting number ofpossible combinations of these proteins, any one of which could formthe optimal "niche" for a desired type of differentiated cell.In their experiments, the UCSD researchers took advantage of theknowledge that the extracellular matrix in liver is comprised primarilyof just five pro...Growth in the sea comes down to a struggle for iron
...d other phytoplankton, but something odd occurs as these tiny marine plants continue to grow. They begin to...s, a benefit to Wells who normally gets seasick on these voyages. For nine days, she steamed northwest to rendezvous with a research vessel from the Univers...New binding target for oncogenic viral protein
... "When Fbw7 is mutated in cancers, deregulation of these oncogenic Fbw7 targets is thought to contribute to... motif that mimics the destruction signal found in these proteins." However, unlike the other substrates recognized by Fbw7, T antigen is not destroyed by th...Lack of enzyme turns fat cells into fat burners
...lAcademy of Sciences. "Westudied the fat cells in these mice bred to lack ACC2," said Dr. SalihWakil, chair of the BCM department of biochemistry and molecularbiology. "We found that the adipose in the mutant mice are nowoxidizing fat, hydrolyzing (breaking down using water) fat, and passingit on to the h...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
...wing higher levels of blood glucose. "By 6 months, these levels had spiked abnormally, to 500 mg/dl -- the ...study, we needed to find out what was happening in these mice, before they got the problem." Their insulin levels provided a clue. In the prenatally underno...Neuronal 'traffic jam' marks early Alzheimer's disease
... progresses, one person could by chance accumulate these blockages more than another," said Goldstein. "And...se." Goldstein emphasized that any application of these findings to potential diagnostic tests or new therapies remains speculative at this time. "However, ...Current human embryonic stem cell lines contaminated UCSD/Salk team finds
...ly availableserum replacements, apparently because these are also derived fromanimal products," said both papers' senior author Ajit Varki, M.D.,UCSD professor of medicine and cellular & molecular medicine, andco-director of the UCSD Glycobiology Research and Training Center.The research in Nature Medi......used to substantiate the claims and how accessible these were to physicians who may want to verify the rese...on, 8 percent of the original research reported in these journal issues was funded by a pharmaceutical company or had an author affiliated with the company, ...Drug That 'Tags' Decision-making Areas Of The Brain May Aid
...ne addiction and other clinical conditions inwhich these brain regions have been implicated,?Mukherjee said...enknown to have a 30 percent to 50 percent loss of these receptors “Ifthere is a gradual loss of these receptors over time, Nifrolidine couldbe a potential m...Elusive HIV shape change revealed; Key clue to how virus infects cells
...ape change; the new findings may help pin down how these compounds work and hasten their development into drugs. "The findings also will help us understand why it's so hard to make an HIV vaccine, and will help us start strategizing about new approaches to vaccine development." The studies, performed in t...Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
...ings."If you look under the electron microscope at these swellings, they arefilled with abnormal amounts of...t's going wrong in the nerve cellbranches that get these swellings," Holtzman says. "Is it really acellular transport problem, or do the swellings result fro...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...co-inhabitants of the human gut. Identification of these genes sheds new light on the unusual shared biolog...rdia lamblia. "The enzymes that form the basis of these shared metabolic strategies are substantially different from human enzymes, making them potential ta...Key molecule in plant photo-protection identified
...ings."If you look under the electron microscope at these swellings, they arefilled with abnormal amounts of...t's going wrong in the nerve cellbranches that get these swellings," Holtzman says. "Is it really acellular transport problem, or do the swellings result fro...Newly-discovered class of genes determines ?and restricts ?stem cell fate
...e is right. Understanding the molecular control of these genes has implications for therapies that involve tissue regeneration. The researchers found that Pax3, a gene critical in embryonic development of melanocytes ?cells that make and store the pigments in the skin and hair ?is also expressed in adult ...Tiny particles could solve billion-dollar problem
... considered one of the most hazardous chemicals at these sites because of its prevalence and its toxicity. ...for reaction. "We've documented the efficiency of these catalysts in breaking down TCE, and the next step is engineering a system that will allow us to get ...UW's Rosetta software to unlock secrets of many human proteins
...s andreturns those with the lowest Rosetta scores; these conformations comeclosest to the actual shape of the protein.Rosetta was developed in the laboratory of UW Professor David Baker bya large team of scientists and students. Former post-doctoral fellowRichard Bonneau, who is now with the ISB, is the te...Plants, animals share molecular growth mechanisms
... most cells. They found that the shape and size of these hairs, or trichomes, readily show when genes affec...am developed will help scientists learn more about these functions in both plants and animals. The other researchers on this study were Dipanwita Basu and S...Researchers find how protein allows insects to detect and respond to pheromones
...s andreturns those with the lowest Rosetta scores; these conformations comeclosest to the actual shape of the protein.Rosetta was developed in the laboratory of UW Professor David Baker bya large team of scientists and students. Former post-doctoral fellowRichard Bonneau, who is now with the ISB, is the te...Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
... and more effectively," said Dr. Chiorazzi. "Once these new prognostic markers are clinically available to...l count seen in patients due to an accumulation of these immature and incompetent white blood cells. Scientists have since discovered that CLL cells do indee...Researchers Uncover Key Step In Manufacture of Memory Protein
...n bubble-like structures known as vesicles. Within these vesicles, proBDNF is converted to mBDNF by other e...receives an electrical signal from another neuron, these vesicles fuse with the cell’s outer membrane, open up, and release mBDNF. During their research, Dr...