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Tag: "therapy" at biology news

Pregnancy hormone key to repairing nerve cell damage

...s. "This discovery has the potential to take MS therapy a step further than current treatments that stabilize the disease in its early stages. By promoting repair, which is the goal of prolactin therapy, we have hope of actually improving symptoms in people with MS," says Dr. Luanne Metz, director of the ...

Lead-'scrubbing' drug may also improve muscle function in lead-exposed children

...innati (UC) environmental health researchers say a therapy commonly used to remove dangerously high levels of...ldren treated with succimer (SUX-sim-er) chelation therapy showed a 19 percent improvement in their ability to perform moving tasks—such as crossing an obstacl...

Moonlighting enzyme linked to neurodegenerative disease

...egulation of frataxin and could represent a target therapy for Friedreich's ataxia," says Dr. Isaya. The severity of Friedreich's ataxia is proportional to the decrease in the levels of frataxin: the lower the frataxin, the more severe the disease. "Yet, this correlation does not completely explain the cl...

Adding radiation decreases breast cancer recurrence

... along with adequate duration of adjuvant hormonal therapy for hormone-responsive tumors, be considered standard therapy in women of all ages and comorbidities, excepting those with very limited life expectancies." ...

Ultrathin films deliver DNA as possible gene therapy tool

Gene therapy - the idea of using genetic instructions rather than drugs to treat disease - has tickled scientists' imaginations for decades, but is not yet a viable therapeutic method. One sizeable hurdle is getting the right genes into the right place at the ri...

Reactivated gene shrinks tumors

...53 proteins to a functional state, as well as gene therapy techniques that introduce a new copy of the p53 gene into tumor cells. One class of potential drugs now under investigation, known as nutlins, acts by interfering with MDM2, an enzyme that keeps p53 levels low. In follow-up studies, the MIT resear...

Protein found that slows hepatitis C growth in liver cells

...this better is likely to suggest new approaches to therapy for this difficult to treat disease." Hepatitis C chronically infects approximately 170 million people worldwide. The most effective treatment for the virus, interferon-based therapy, eradicates the virus less than 50 percent of the time and cause...

Protein therapy may reduce infarct size in heart attack patients

...o major safety concerns were demonstrated with the therapy since the incidence of serious adverse events was similar among patients treated with KAI-9803 compared to placebo, even at the highest dose levels of the study. "In this early study, we believe the data suggest a potential therapeutic role for ...

Turning a cellular sentinel into a cancer killer

.... "And I think the challenge—which is true for any therapy where you can get resistance—is to come up with combination treatments that take out enough of the cancer cells early on that there aren't enough variants left to get around the p53 pathway." Jacks added that "the main point is that—although there ...

Nanoparticles for delivery of prostate cancer treatment

...n to expand research on the delivery of a targeted therapy for prostate cancer using nanoparticles. Garen...pid-covered, gene delivery packets ?to deliver the therapy in animal models of human metastatic prostate cancer. "While we can directly inject the purified...

Stem cell therapy shows promise for rescuing deteriorating vision

...Lund, who has conducted pioneering studies of cell therapy for eye disease. "We didn't expect that at all. We've used a number of different cell types from different sources and these have given us the best results we've ever got." How the cells act to preserve the deteriorating eye cells remains unknown,...

New test helps identify hepatitis C patients at high risk of developing cirrhosis

...r Celera, which also funded the study. "Current therapy for hepatitis C unfortunately is very expensive, h...ffects. And only half of patients undergoing this therapy will be cured of the infection. Nearly 4 million Americans are infected with the hepatitis C viru...

Cancer cells forming blood vessels send their copper to the edge

...covery may help explain how copper-reducing cancer therapy works." The findings are reported in the current issue of the Proceedings of the National Academy of Sciences, or PNAS. "We began our study," Finney explained, " by examining a model of angiogenesis that uses human microvascular endothelial cells ...

Widely used hepatitis B drug spurs HIV drug resistance

...d news is that co-infected patients already on HIV therapy can still use entecavir to treat their hepatitis B, but the bad news is that there are now fewer options for treating hepatitis B first," she adds. Hepatitis B infection attacks the liver and can lead to cirrhosis, liver cancer or even death from li...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

... and Harefield NHS Trust gave the full combination therapy to 15 severely ill patients. Of these 15, 11 recov... hearts and the risk of organ rejection. "This therapy has the potential to ease the pressure on the waiting list while also offering patients a better alt...

St. Jude announces breakthrough in eye cancer treatment

...g for any childhood cancer, Dyer said. Targeted therapy uses a customized drug to disable a specific molec...ng cancer cells in the eye. "When successful, this therapy often saves vision," Wilson said. "Clinicians at major medical institutions generally save 70 percen...

Gene key to taste bud development identified

...ancer patients receiving chemotherapy or radiation therapy often report the loss of taste during treatments. These therapies target cells that are dividing, making them effective in killing cancer cells but also causing the unwanted side effect of killing taste buds. When the cancer treatments end, the taste...

Monoclonal antibody reduces exacerbations in asthmatics

...tokine, produced by white blood cells. "Anti-TNFá therapy has been shown to be effective in patients with rh...ical diary," said Dr. Hansel. "Although infliximab therapy did not show significant efficacy for the primary endpoint of monitoring peak expiratory flow (PEF),...

Proteins may predict lung transplant rejection

...protein function Lung transplants are a common therapy for many end-stage lung diseases such as chronic obstructive pulmonary disease, cystic fibrosis, pulmonary hypertension, idiopathic pulmonary fibrosis and other diseases. Patients who receive a new lung may suffer bouts of acute or chronic rejecti...

Signal protein shows promise for blocking tumor promoters in skin cells

...gical Chemistry, suggests a target for future gene therapy to treat skin, head, neck, colon, and breast cance...at are triggered by activated Src kinases. Such a therapy would likely use an adenovirus to carry a gene that codes for Srcasm into skin cells to increase Src...

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