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Tag: "therapy" at biology news

Researchers urge monitoring of bone health during chemotherapy

...s growth factor encourages bone breakdown, and any therapy that decreases bone density could potentially enhance tumor growth in bone," says senior author Katherine Weilbaecher, M.D., assistant professor of medicine and of cell biology and physiology. "But there are things that can be done to counteract this...

Study identifies risk factors for spread of respiratory infections in hospitals

...ile having symptoms of SARS, and the use of oxygen therapy were the most significant risk factors associated ...gap in the knowledge of how oxygen and ventilation therapy may promote the spread of infection. Future research should include investigating the safety of high...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...low physicians to personalize lung or brain cancer therapy and lower the risk of unnecessary radiation treatm...able to tell if a patient is not responding to the therapy and alter their treatment strategy accordingly." The researchers screened lung and brain tumors t...

Carnegie Mellon University research shows how sensory-deprived brain compensates

...tion much better. This kind of "forced use" therapy is already applied in the clinic for patients with motor deficits. For example, a patient who suffers a brain injury is made to use a poorly performing arm with the expectation that the brain may be plastic enough to assist that arm in recovering mot...

OHSU lab finds meth receptor that could lead to therapy

...resents a completely new target for pharmaceutical therapy to treat meth addiction and also reduce the negative manifestations of its abuse. "Meth addiction is such a problem and we have nothing to treat it with except group support therapy," Grandy said. "Now we have a new target, something completely di...

Gene therapy for blindness clears hurdle in mice

...y of Florida researchers have used an experimental therapy in mice to shut down a gene that plays a crucial r...abling the gene is a step toward developing a gene therapy to treat people with retinitis pigmentosa, an inherited disease that attacks the light-sensing cells...

Dual gene therapy suppresses lung cancer in preclinical test

Combination gene therapy delivered in lipid-based nanoparticles drastically...emotherapy, and we also combine different modes of therapy - surgery, radiation and chemotherapy. Now you've got the possibility of combined targeted gene ther...

HIV protein enlisted to help kill cancer cells

...teins such as TAT-Bim with chemotherapy, radiation therapy and other anticancer therapeutics in hopes of further increasing cell-suicide signals within cancer cells....

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

...ality of life for many CF patients, before CF gene therapy becomes a reality. The Penn research team demonstrated the disruptive action of SMase in frog oocytes (egg cells) engineered to place CFTR in their membrane. These oocytes are an experimental tool that allows the researchers to assess the flow of ...

Gene expression test reveals ER and HER-2 status of breast tumors

...also gauge the sensitivity of the tumor to hormone therapy and chemotherapy," says Lajos Pusztai, M.D., Ph.D., associate professor in the M. D. Anderson Department of Breast Medical Oncology, and team leader with Symmans. ER-positive tumors are treated with estrogen-suppressing drugs such as Tamoxifen. T...

Molecular signature may identify cisplatin-sensitive breast tumors

...lar pathway that makes these tumors sensitive to a therapy infrequently used for breast cancer," says Leif Ellisen, MD, PhD, of the MGH Cancer Center, senior author of the study to appear in the May 2007 Journal of Clinical Investigation and receiving early online release. "We’re excited that this work has l...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...meeting in Los Angeles. Other attempts at gene therapy have employed an adenovirus to deliver the therap...mine has eliminated that so far. Previous gene therapy clinical trials also involved direct injection into tumors. "This is the first time anyone has show...

Stem cell transplants explored at Stanford as a possible treatment for hearing loss

...rom Harvard, he's been focused on two paths: drug therapy -which could be as simple as an application of ea... first have to find it." The idea of using drug therapy to cure deafness has been at the back of Heller's mind since he began researching the inner ear 12 ...

Scientists uncover new target in cancer mutation puzzle

...meday Rho may prove to be an attractive target for therapy because it is highly active only in malignant cells and not in normal cells. "Now that we understand more about the role of Rho proteins as a target of cooperating cancer gene mutations in tumors with p53 mutations, we will look for other molecule...

RNAi shows promise in gene therapy, Stanford researcher says

...alled RNA interference could be an effective gene therapy technique. Since then he has used RNAi gene therapy to effectively shut down the viruses that cause hepatitis and HIV in mice. With three human RNAi g...

Batten down the hatches against HIV

A promising approach to gene therapy involves short DNA fragments (interfering RNA) that bind to specific genes and block their "translation" into the corresponding, disease-related protein. A stumbling block has been the efficient and targeted delivery of RNA into the cells. Researcher...

Resistance to anti-HIV drugs in Uganda developed due to drug supply problems

...o treatment leads to better survival than self-pay therapy because free treatment may be less susceptible to ...s and drug supply management in any antiretroviral therapy program as well as continued monitoring of adherence. While our patients did a great job of taking t...

NIH announces phase III clinical trial of creatine for Parkinson's disease

...s disease (PD). While creatine is not an approved therapy for PD or any other condition, it is widely though...his study is an important step toward developing a therapy that could change the course of this devastating disease," says Elias A. Zerhouni, M.D., director of...

Can engineered immune cells stop AIDS?

Twenty years after its introduction, gene therapy still holds great promise as a way to harness the ...ost important implication of the work is that gene therapy could now be carried out as an inexpensive procedure, able to be considered even in the less-develop...

Inhibiting blood to save the brain

...d," said Akassoglou, adding that this potential MS therapy might also have applications to other blood-brain barrier diseases where blood leakage and microglia activation is present such as spinal cord injury, Alzheimer's disease or stroke. ...

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