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Tag: "therapeutics" at biology news

HIV and malaria combine to adversely affect pregnant women and their infants

...vaccines. "This is only the first step in creating therapeutics to treat this devastating disease," he stresses. "We hope to help translate this knowledge into more effective vaccines designed to generate these types of protective antibodies."...

Toxoplasmosis infection trick revealed by scientists

...the cell’s invasion, there is potential to develop therapeutics that are targeted at disrupting this mechanism, therefore thwarting infection." Toxoplasma gondii, the parasite that causes toxoplasmosis, is one of the world’s most common parasites. Around a quarter to half of the world’s population is thought t...

It's never too late to get it back! Aging interrupted

...portant effects of low calorie diets and longevity therapeutics given late in life may not be to prevent this damage, but instead to stimulate the body to eliminate damaged cells that may become cancerous, and to stimulate repair in damaged cells like neurons and heart cells. Low calorie diets drive the body to ...

Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising

...very year for the delivery of vaccines and protein therapeutics such as insulin, growth hormone and erythropoietin, a red blood cell booster. Needle-free delivery of vaccines has recently been identified as one of the significant emerging challenges in global health. The researchers felt that the pain and bru...

Discovery could lead to better control of hemorrhagic fever viruses

...tibodies have already been developed as anticancer therapeutics (cancer cells are also high in TfR1), and some have already been through clinical trials. Choe's lab will test these antibodies, hoping to find one that inhibits virus entry without compromising TfR1's essential function in cellular iron uptake. ...

Soft-cell approach cuts animal tests

... contaminants, combustion products and respiratory therapeutics and lead to a better understanding of the interactions between chemical exposure and toxic effects of single chemicals and chemical mixtures. ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

.... "Individuals respond differently to different therapeutics because there are substantial differences in the spectrum of genetic, biological and epigenetic characteristics between breast cancers, although some recurrent abnormality patterns are emerging that define breast cancer subtypes" said Joe W. Gray, Ph...

HIV protein enlisted to help kill cancer cells

...emotherapy, radiation therapy and other anticancer therapeutics in hopes of further increasing cell-suicide signals within cancer cells....

Protein found to shield pancreatic cancer cells from self-destruction

...l Lopez-Berestein, M.D., professor of experimental therapeutics and study co-author, notes that the research also shows that the self-consuming cell death prevented by TG2 is independent of a prominent molecular pathway also known to regulate autophagy called the mammalian target of rapamycin. "Targeting TG2, ...

Coated nanoparticles solve sticky drug-delivery problem

...sible," said Hanes, who also serves as director of therapeutics for the Institute for NanoBioTechnology at Johns Hopkins. "The shocking thing was how fast the particles that were 500 nanometers wide moved through the mucus mesh. The work suggests that the openings in the mucus barrier are much larger than origina...

Novel laboratory technique nudges genes into activity

...ical cousin of DNA, to turn on genes could lead to therapeutics for conditions in which nudging a gene awake would help alleviate disease, researchers at UT Southwestern Medical Center say. The gene-activating method, which is being developed by UT Southwestern scientists, also is providing researchers with a n...

MIT device draws cells close -- but not too close -- together

...m devise different approaches to engineering liver therapeutics by helping them understand exactly which signals are needed to support specific liver cell functions. Instead of building an entire liver from scratch, Bhatia wants to isolate the key cell type, "the business end of the organ," and get it to work wit...

New imaging technique tracks traffic patterns of white blood cells

...and provide a powerful tool for the development of therapeutics for these diseases," according to Mount Sinai researchers. "Sickle cell anemia was the first disease characterized at the molecular level but there is still no treatment for the acute vascular occlusions which are the hallmark of the disease," sa...

HIV gets a makeover

...t will likely change the way that AIDS vaccine and therapeutics research is done," Bieniasz says....

Twenty Years of Malaria Research: Outcomes and Perspectives

...of topics related to malaria, from epidemiology to therapeutics and from immunity to socio-economics. As the Shoklo Malaria Research Unit (SMRU) in Mae Sot, Thailand, which borders Burma, celebrates its twentieth anniversary, its Director, Professor François Nosten, is able to reflect on the success of the unit...

Two-faced protein can stop metastasis or promote it, researchers say

...s open up a whole new field of discovery for novel therapeutics that should be applicable to most types of tumors." Their laboratory study looks at how p120 catenin interacts with different cadherin cell adhesion proteins in cancer cells. Cadherin proteins go through a cell membrane, and on the outside, they act...

Parkinson's mutation stunts neurons

...imal models may promote the discovery of effective therapeutics for LRRK2-associated disease," they wrote. ...

Molecular 'on/off switch' controls immune defenses against viruses

...ses, highlighting a potential new target for novel therapeutics to fight viruses, the researchers report. In a ...search team and others are working to design novel therapeutics and drugs that could mimic viral effects on RIG-I to spur antiviral response or, conversely, mimic v...

Expanding waistlines triggered by your genes

... adipocyte biology and possibly will provide novel therapeutics to prevent the progression of obesity. The researchers will continue to work on the cellular mechanism of obesity and metabolic diseases from the perspective of 3-D cell biology. ...

Origen publishes in Nature a robust and versatile method for creating transgenic chickens

...on of genetic elements for the production of human therapeutics and the modification of the chicken immune system ... the potential for the production of human protein therapeutics in chicken eggs in August 2005, when company scientists published in Nature Biotechnology the produc...

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