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Tag: "therapeutic" at biology news

DNA Molecules Used To Assemble Nanoparticles

...usters are in the works. "If you wanted to make a therapeutic that targeted five drugs to five different cells, it would be 25 synthesis steps the traditional way," Baker said. At two to three months per synthesis, and a significant loss of yield for each step, that approach just wouldn't be practical. Instead...

Wisconsin scientists grow critical nerve cells

... UW-Madison. Scientists have long believed in the therapeutic promise of embryonic stem cells with their ability to replicate indefinitely and develop into any of the 220 different types of cells and tissues in the body. But researchers have struggled to convert blank-slate embryonic stem cells into motor neur...

Spleen may be source of versatile stem cells

...report. "Ifso, these cells could have much broader therapeutic applications thansuggested by our earlier work."In 2001 Faustman's team found that a treatment designed to address theautoimmune reaction underlying type 1 diabetes actually cured thedisease in diabetic mice. Late in 2003 they reported the mechanismb...

Priming embryonic stem cells to fulfill their promise

...needed to turnembryonic stem cells into cells with therapeutic potential," saidBhatia. "We think we've developed an enabling technology for stem cellresearch and other areas of cell biology in the sense that all of asudden scientists can use inexpensive and widely available reagents andmachinery to optimize the ...

Neuronal 'traffic jam' marks early Alzheimer's disease

...res could prove valuable in testing diagnostic and therapeutic approaches, said Goldstein. The researchers are also analyzing more brain tissue samples from humans with Alzheimer's disease, to confirm their findings of the early transport defects and their effects on neuronal death. ...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...non-human molecule thatcompromises their potential therapeutic use in human subjects,according to research by inv...ies, and thus renderingthem useless as a potential therapeutic tool in humans."It's an important safety issue because this opens up the idea thatmetabolic transfer...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

...tovase. The researchers emphasize that the drugs' therapeutic benefits are still greater than the risk of heart problems linked to their use. They urge physicians to apply this new finding by following their patients more closely over the long term, and by looking specifically for heart rhythm irregularities in...

Scientists seek answers on what activates deadly anthrax spores

...ural vulnerabilities that are key to designing new therapeutic agents to prevent anthrax. Interest in determining how to stop anthrax remains high, not only after the 2001 attacks through the mail that resulted in 18 cases and five deaths, but also after the recent scare at two military mailroom facilities when...

A bacterial genome reveals new targets to combat infectious disease

...two decades, these results may quickly lead to new therapeutic strategies against these parasites. ### Citation: Foster J, Ganatra M, Kamal I, Ware J, Makarova K, et al. (2005) The Wolbachia genome of Brugia malayi: Endosymbiont evolution within a human pathogenic nematode. PLoS Biol 3(4): e121. ...

Gene variations explain drug dose required to control seizures

...quired by different patients and the drug's narrow therapeutic index, explained study co-author Nicholas Wood, Ph.D., of the University College London. The therapeutic index refers to the ratio between a drug's toxic and therapeutic dose, used as a measure of the drug...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...nique challenge, because replacement of deficient, therapeutic proteins invokes an immune response that limits th...gene therapy remains, he added. In gene therapy, a therapeutic gene is delivered to patient cells, often using a modified virus. Gene therapy might offer an alter...

Vital step in cellular migration described by UCSD medical researchers

...t into cell migration and ultimately could lead to therapeutic interventions in autoimmune diseases such as multiple sclerosis and Crohn's disease," said the paper's first author Naoyuki Nishiya, Ph.D., a postgraduate researcher in the lab of senior author Mark Ginsberg, M.D., UCSD professor of medicine. "Since ...

UCSD researchers maintain stem cells without contaminated animal feeder layers

... provoke an immune system attack eliminating their therapeutic value. While several laboratories have attempted to grow stem cells in alternative cultures, problems have remained. In some cases, human feeder layers were developed but this added another measure of complexity to the culture system, Hayek noted. I...

Scientists identify genetic pathways essential to RNA interference

...ly specific, which gives it enormous potential for therapeutic application," says Gary Ruvkun, PhD, of the MGH De...form what has been a research tool into a powerful therapeutic tool. Although the process has worked well in studies of cultured human cells, it has not yet been e...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...lled marmosets prevented brain damage by producing therapeutic levels of a protein that helps nourish brain cells...ental fluctuations of L-dopa levels, a continuous, therapeutic dose would be better for you. As for efforts to reverse impaired movements in rats, scientists used...

Researchers add new tool to tumor-treatment arsenal

...y of cancers," says Dr. Thomas. "However, a narrow therapeutic window, combined with possible severe side effects, has greatly limited their broader use." These factors, says Dr. Thomas, have probably contributed to recent reports of the under-dosing of patients and the failure to blunt the disease. When cance...

UCLA scientists transform HIV into cancer-seeking missile

...as been hampered by the lack of a good carrier for therapeutic genes that can travel through the blood and aim it... AIDS virus acts like a Trojan horse ?transporting therapeutic agents to a targeted part of the body, such as the lungs, where tumors often spread," said Chen, a p...

Beyond lithium for bipolar disorder

... it is tempting to speculate that PACAP night be a therapeutic effector of lithium in bipolar disorder." They concluded that "the data presented here warrant further investigation of PACAP signaling in the brain and of the orphan receptor GPR88 as potential new targets in bipolar disorder." Philip E. Brandish,...

Study of genomic DNA leads to new advances in cancer diagnostics

...basis for the design of a new generation of cancer therapeutic agents. Research was funded by the National Institute of Health and the Department of Energy. This work involved collaborators at the University of Illinois at Chicago Department of Pathology, the University of Illinois at Chicago Cancer Center, th...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

... mesenchymal genetic modifiers, and into potential therapeutic approaches that affect the signaling between the two cell layers. ...

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