pHLIP, a novel technology to locate and treat tumors
...bdomen of a mouse, find its way into the blood and then specifically accumulate in tumors. Within 20 hours after injection of labeled pHLIP, the molecules had passed through the bloodstream and accumulated in mouse breast tumors grown to different “stages?on the leg of a mouse. The researchers demonst...Scientists discover rare 'gene-for-gene' interaction that helps bacteria kill their host
... produce reactive molecules that kill bacteria and then encapsulate them in a dense coat of black pigment ..., the bacteria were less virulent. The researchers then used a technique known RNA interference to prevent the insects from producing the phenoloxidase enzy......to send in a sequence coding for a protein that is then converted into music and returned to the inquirer as a midi file....Vaccine prevents prion disease in mice
...elk occurs and if it were transmissible to humans, then we would need a vaccine like this to protect people in hunting areas." He also noted that a vaccine that decreases the spread of prion disease in animals also reduces the possibility that the disease could infect humans. ...Master regulatory gene of epithelial stem cells identified
...enance of stem cells, McKeon and his research team then used the epithelial stem cell cloning methods developed by Howard Green, MD, the George Higginson professor of cell biology at HMS, to show that p63’s key function was to provide the enhanced potential of stem cells to divide. "The fact that p63...Alien plants attack using 'resource conservation' as weapon, researchers say
...ntrolled the amount of light reaching the leaf and then measured photosynthesis and water-use rates. Later...re really resource efficient," Vitousek said. "And then we can hunt those down." ...First clinical trial of gene therapy for childhood blindness
... therapy treatments must be individually developed then tested in a separate clinical trial specifically for that disease. However, the results from this first human trial are likely to provide an important basis for many more gene therapy protocols in the future, as well as potentially leading to an effe...8 plants from South Africa may hold potential for treating high blood pressure
...onstrated ACE inhibition activity. The plants were then subjected to a gelatin salt block test for tannins to eliminate any false positive results. None of the plants tested positive for tannins, hence eliminating any false positive results. Ultimately, the eight plants that showed significant ACEI ac...An ancient bathtub ring of mammoth fossils
...ater would back up, creating temporary Lake Lewis, then slowly drain through to the Columbia River Gorge—all in a matter of days. Preliminary results place most mammoth finds in the Lake Lewis area at elevations of 600 to 1,000 feet, which echoes the distribution of boulders that originated from far aw...Newborn neurons like to hang with the 'in' crowd
...h at the University of California, San Diego, Toni then zoomed in at a nanometer scale and watched how the young and the old got acquainted. He observed that between three and four weeks after injection of the virus newborn neurons sent out dendritic filopodia—tiny feelers that probe the environment. ...Genetic roots of bipolar disorder revealed by first genome-wide study of illness
... of the cost of individual scans. The researchers then zeroed in on the gene variations that occurred mor... focusing on US participants of European ancestry, then repeating the study in a large group of patients in Germany. Similar outcomes were found in both po...New Brandeis research sheds light on memory by erasing it
... first time that memory storage can be induced and then biochemically erased in slices of rat hippocampus ...chemically attacked and previous memory erased, it then became possible to insert new memories in the synapses. Alzheimer's and other diseases in which ...Risk of lymphoma increases with hepatitis C virus infection
...ify conditions which may lead to cancer. It might then be possible to prevent progression to lymphoma," said investigator Eric A. Engels, M.D., from the Viral Epidemiology Branch of NCI's Division of Cancer Epidemiology and Genetics. "More research is needed to further clarify the relationship between H...Scientists identify prion's infectious secret
.... Prions are proteins that start out normally, but then at some point misfold—rather like an origami swan ...red the array with peptides from baker’s yeast and then added prion protein to the array, also from the same yeast species. He found that a small cluster of...Diminishing dinosaur steps saved by laser and laptop
...ff the quarry faces back to a receiver. The device then cross references the reflections with a built-in d...e information into an attached laptop. Software is then used to create a detailed and very accurate 3D computer model of the location. This technology ha...DNA repair proteins monitored at double-strand break
...ves into the nucleus and cleaves the DNA. The team then used a biochemical technique called chromatin immunoprecipitation to collect and identify repair proteins and show where each one bound to the DNA. ...Survival of the rarest: Fruit flies shed light on the evolution of behavior
... "If you're a rover surrounded by many sitters, then the sitters are going to use up that patch and you're going to do better by moving out into a new patch," says Sokolowski. "So you'll have an advantage because you're not competing with the sitters who stay close to the initial resource. On the other...LIAI scientists make important finding on cytomegalovirus transmission
...ity of the IL-10 molecule to bind to its receptor, then you allow these T cells to do their job and reduce or eliminate this virus." Croft said the scientists also tested a second approach, which used a stimulator antibody in mice to boost the action of the OX40 protein. OX40 helps T cells replicate m...Toxoplasmosis infection trick revealed by scientists
...host cell, assisting the parasite to stick to, and then enter the human cell. Using a novel carbohydrate microarray the team were able to identify the precise sugars to which the parasite protein binds. Following this the team used a combination of NMR spectroscopy and cellular studies to characterise......c current on the Pacific side of Cape Horn. It then streams through into the Atlantic with the current, but in the process is spread, shifted and diffused by the circulation. Measurements of this spreading of the helium were used to deduce the ‘short-circuit? ...