An HIV Protein Plays a Surprising Role in Gene Activation
...are expert manipulators when it comes to co-opting their host's cellular resources. A great deal of human c...olved myriad ways of redirecting that machinery to their own benefit. Humans and other eukaryotes have three types of RNA polymerases, each charged with tra...Mouse brain tumors mimic those in human genetic disorder
...y School of Medicine in St. Louis.After validating their animal model, the team made two importantdiscoveri... complicationsincluding brain cancer.To supplement their clinical research, Gutmann's team developed a mousemodel in which the animals, like humans with the ...Automatic extraction of gene/protein biological functions from biomedical text
...techniques. When the gene/protein/family names and their functions are described in ACTOR (doer of action) and OBJECT (receiver of action) relationships, the corresponding GO-IDs are assigned to the genes/proteins/families. The gene/protein/family names are recognized using the gene/protein/family name dic...New Clues Add 40,000 Years to Age of Human Species
...and John Fleagle of Stony Brook University, report their findings in the Feb. 17 issue of the journal Natur...tedly contested,?notes Fleagle. At the request of their Ethiopian colleague Zelalem Assefa, now at the National Museum of Natural History in Washington, D.C...A bacterial genome reveals new targets to combat infectious disease
... themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiting from the other. Indeed, the Wolbachia bacterium is so crucial to its host nematode that apparently eradicating it with antibiotics severely compromises the nematode'...Spider Venom Could Yield Eco-Friendly Insecticides
...der -- toxins that either paralyze insects or send their nervous systems into overdrive. King's NSF-funded research has provided the first detailed descriptions of the regions of the toxins that are essential for interaction with insect ion channels. (Ion channels allow the movement of ions -- small charge...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
...r, they had another diffusion MRI. After finishing their treatment, the participants underwent standard MRI to determine whether their tumor responded to the therapy. After three weeks ?more than two months before the final MRI scan ?...Gene variations explain drug dose required to control seizures
...ter predict the dose of drugs necessary to control their seizures, suggest basic findings by researchers at...e the time required for patients with epilepsy and their physicians to reach an effective dose of the medications that control seizures, said David Goldstein...Solution to Pollution: New Bacteria Eats Toxic Waste
...solates. They answered questions about the size of their chromosome and whether plasmids were present in the mycobacterium. “Putting together genomes tells us a lot about the history of the world and may even help us with its future,?said Joanne Hughes, a Utah State Biology professor. The Department of En...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...ey reach the age of two. The researchers also said their approach of targeting corrective genes to muscles may have application in treating other muscular dystrophies. Patients with Pompe disease have a defect in a key enzyme that converts glycogen, a stored form of sugar, into glucose, the body's primary...Enzyme shown to help protect genomic stability
...und the histones, the genes cannot be accessed and their expression is repressed. When the coils of DNA around the histones are loosened or the histone molecules are altered, the genes become available for expression. It is the complex activity governing this process to which Ubp10 contributes. Enzymatic ...BRCA1 causes ovarian cancer through indirect, biochemical route
...at women who have regular menstrual cycles through their life without interruption by pregnancy or oral con... in people with identified BRCA1 mutations, making their risk of ovarian cancer drop precipitously. In addition, once the chemical messenger that's affected...Scientists decipher genome of fungus that can cause life-threatening infections
...rulence, we foundsurprisingly little difference in their gene content."TIGR scientists led by primary inves...coccal infection at some point duringthe course of their HIV disease. The disease caused by the fungus,cryptococcosis, sometimes involves a fatal brain infla...Needling Chromosomes Reveals Cell Division Secret
...hair, a Duke Universitygraduate student has tested their "stickiness" to one another duringcell division. H...Biology, Leocadia Paliulis andBruce Nicklas report their progress in understanding how the pairs ofchromosomes in each cell manage to balance their adhesion ...Poplar trees redirect resources in response to simulated attack
...ants' resistance to environmental challenges -- or their ability to perform useful tasks such as carbon seq...-- could also use functional imaging to help track their progress. In the New Phytologist study, the scientists asked how plants deal with an external stres...In the sea slug's defense against lobsters, confusion is key
... which such chemical attacks actually work against their intended targets are not well understood by researchers. New work has now shown that such chemical defenses can involve modes of trickery that had not previously been appreciated as components of chemical defense. When attacked by predatory spiny lo...Scientists discover the cellular roots of graying hair
...colleagues discovered that as the rodents aged and their hair beganturning gray, the numbers of stem cells ...ing this gene. In adramatic fashion, the mice lost their melanocyte stem cells shortlyafter birth and quickly went gray. It may be that people who graypremat...Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
... in root nodules and give these specialized organs their distinctive red color. Legume root nodules accommodate bacteria, called rhizobia, that reduce atmospheric nitrogen to ammonia, which is subsequently used by the plant for growth and colonization of nitrogen-poor soils. Symbiotic nitrogen fixation is ...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
...colleagues discovered that as the rodents aged and their hair beganturning gray, the numbers of stem cells ...ing this gene. In adramatic fashion, the mice lost their melanocyte stem cells shortlyafter birth and quickly went gray. It may be that people who graypremat......f culture materials required to keep stem cells in their undifferentiated "blank slate" state. Embryonic st...elopmental pathways. Maintaining stock cultures in their undifferentiated state is critical. The feeder cell dogma now can be overturned, says lead investig...