Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
Gene therapy methods that specifically target muscle may reverse the symptom...s with Pompe disease have a defect in a key enzyme that converts glycogen, a stored form of sugar, into glucose, the body's primary energy source. As a resu...Enzyme shown to help protect genomic stability
...and beyond are characterized by extensive segments that are inactive, lengthy stretches of DNA containing multiple genes that are closed to gene transcription. Scientists believe one reason for this broad gene silencing is the...BRCA1 causes ovarian cancer through indirect, biochemical route
...School and principal investigator on the paper. If that were the case, it would mean that mutation of the gene would allow the cell it's in to grow out of control and create a tumor. Instead...Scientists decipher genome of fungus that can cause life-threatening infections
In a project that already has benefited animportant field of biomedi...n opportunistic human pathogenof global importance that is used by researchers as a model for fungalpathogenesis. Since the 1980s, the number of Cryptococcu...Needling Chromosomes Reveals Cell Division Secret
...romosomes are thetiny fiber structures in the cell that house its genes. They replicateand separate in the...wn apart to separate poles of the dividing cell so that each new "daughter" cell contains a singlecopy of each. The same basic process operates in normal ce...Poplar trees redirect resources in response to simulated attack
... plants respond to environmental stress, and shows that radiotracer imaging can be a big help in unravelin...xternal stress, such as an insect attack. "We know that plants respond defensively to attacks, for example, by producing chemicals that kill off the attacke...Purdue proves concept of using nano-materials for drug discovery
...archers created a chip about one centimeter square that holds thousands of tiny vessels sitting on top of a material that contains numerous pores. This "nanoporous" material makes it possible to carry out reactions inside ...In the sea slug's defense against lobsters, confusion is key
... understood by researchers. New work has now shown that such chemical defenses can involve modes of trickery that had not previously been appreciated as components of chemical defense. When attacked by predatory s...Scientists discover the cellular roots of graying hair
... color to the gradual dying off ofadult stem cells that form a reservoir that spawns a continuous supplyof new pigment-manufacturing cells, called melanocytes, that give hairits ...Researchers identify target for cancer drugs
...a particular communication pathway inside of cells that contributes to many malignant brain and prostate c... have discovered a missing puzzle piece, a finding that may present drug makers with a significant new cancer target. "We believe that we have identified a...Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
...n unclear. A group of researchers reveal this week that one such mysterious plant hemoglobin serves to ass...n in the root nodules of legumes through a process that is conceptually not unlike that undertaken by mammalian hemoglobins in facilitating oxygen transport...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
... color to the gradual dying off ofadult stem cells that form a reservoir that spawns a continuous supplyof new pigment-manufacturing cells, called melanocytes, that give hairits ...Scientists rid stem cell culture of key animal cells
...versity of Wisconsin-Madison have crafted a recipe that allows researchers to grow human embryonic stem ce...of a recent University of California study showing that existing stem cell lines are already contaminated with an animal molecule. The potential threat of a...Essential mangrove forest threatened by cryptic ecological degradation
...oves, forests thriving at the edge of land and sea that are ecologically and socio-economically important ...m led by Dr. Farid Dahdouh-Guebas has demonstrated that in the recent past an increase in human-environment interactions that affect the hydrology of rivers...... color to the gradual dying off ofadult stem cells that form a reservoir that spawns a continuous supplyof new pigment-manufacturing cells, called melanocytes, that give hairits ...Experiments provide proof of how traveling in groups protects insects
... thousands of wildebeests and other hoofed mammals that form herds and migrate across the African plains. ... own kind and form teeming, hungry islands of life that devour everything in their path that's edible. Some spectacular marching packs stretch several miles...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...st detailed study to date of the protein structure that surrounds the human genome. Their findings reveal...oteins act like spools for the long strings of DNA that contain our genes and form chromosomes. The researchers studied chemical tags that are attached to t...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
...e locations of crucial generegulators, or switches that determine how different parts of the braindevelop ... research on brain tumors andneurological diseases that result from mutations in these switch genes?called “transcription factors.?When these genes are alte...New research questions basic tenet of neuron function
...urons are tiny organelles called synaptic vesicles that sequester neurotransmitters and release them when ...gnal is transmitted to other neurons. It is known that synaptic vesicles release their neurotransmitters in two different "modes" ?one when the neuron is s...Vital step in cellular migration described by UCSD medical researchers
...onse, as leukocytes move toward targets, a therapy that stops that movement could potentially help in autoimmune disorders where the body's immune system incorrectly a...