Molecular machine may lead to new drugs to combat human diseases
The crystallized form of a molecular machine that can cut and paste genetic material is revealing po... some forms of cancer and opportunistic infections that plague HIV patients. Purdue University researchers froze one of these molecular machines, which are...Jefferson Virologists Coax HIV Out of Hiding
...d a way to bring HIV out ofhiding. They have shown that an immune cell protein calledinterleukin-7 (IL-7) ...cythat we’ve seen in the last 15 years.?They found that the virus wasstimulated to higher levels and was activated in more patients thanwith other compounds...Novel Therapy Tested in Mice Could Chase Away Cat Allergies
...by spewing out histamine. Allergy experts estimate that 14 percent of children 6 to 19 years old are allergic to cats. The treatment comprises a molecule that loosely tethers a feline and a human protein together. The feline end is the notorious protein (call...Sea skate experiment sheds light on human cell transport
...y using a plant-based substance to block an enzyme that causes phosphorylation. The result: The gates woul...ut Goldstein and Musch also believe the mechanisms that trigger this cellular "release valve" are universal. "We think that vesicle insertion, coupled with...Color-blind method opens new doors in DNA sequencing
...ine (BCM) and Rice University could open new doors that would take DNA sequencing to the patient's bedside...nd Rice describe a new way of doing DNA sequencing that could be more accurate than current methods. DNA in the nucleus of every human cell is made of long...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...shed the results of an EPA-funded clam embryostudy that supports her hypothesis that, when combined, the p...lly, this is the first time anyone hasdemonstrated that BCE's components can work together to adverselyaffect neuron growth in a model organism.The study, w...Female sex hormones play a vital role in defense against sexually transmitted diseases
..., to be published in the Journal of Virology, show that sex hormones have a profound effect on susceptibil...ch clearly shows, and reaffirms previous research, that in female mice, sex hormones have a profound effect on susceptibility to sexually transmitted infect...Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
... Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, prese...ed let-7, a natural and separately transcribed RNA that maps to a chromosomal region associated with lung cancer as a regulator of Ras expression. DNA of p...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...shed the results of an EPA-funded clam embryostudy that supports her hypothesis that, when combined, the p...lly, this is the first time anyone hasdemonstrated that BCE's components can work together to adverselyaffect neuron growth in a model organism.The study, w...An HIV Protein Plays a Surprising Role in Gene Activation
...s like HIV have evolved myriad ways of redirecting that machinery to their own benefit. Humans and other ...FIID, a large protein complex containing a protein that binds the TATA box (aptly named the TATA-box-binding protein, or TBP) and several cofactors called T...Mouse brain tumors mimic those in human genetic disorder
...lcopies of this same gene.Their latest paper shows that brain tumor formation in these mice hasseveral of ...he time course of tumor development was similar to that seenin humans. Unlike most tumors, optic pathway gliomas associated withNF1 typically stop growing a...Automatic extraction of gene/protein biological functions from biomedical text
... techniques. A preliminary experiment demonstrated that our method has an estimated recall of 54?4% with a precision of 91?4% for actually described functions in abstracts. When applied to the PUBMED, it extracted over 190 000 gene–GO relationships and 150 000 family–GO relationships for major eukaryotes....New Clues Add 40,000 Years to Age of Human Species
...uncovered evidence suggesting human bones found at that time are roughly 195,000 years old. The researche...findings may bolster the “Out-of-Africa?hypothesis that suggests we all trace to an ancient line that first evolved in Africa and then displaced other homin...Enzyme allows B cells to resist death, leading to leukemia
... bonemarrow, and lymphatic tissues. It is believed that in the early stagesof disease, B-CLL is the result of an undefined defect in theprogrammed signals that trigger normal B cell death (apoptosis). LivioTrentin and colleagues from Padua University School of...A bacterial genome reveals new targets to combat infectious disease
...k for infection with filarial nematodes, parasites that cause elephantiasis, African river blindness, and ...de. The nematodes themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiti...Spider Venom Could Yield Eco-Friendly Insecticides
... versuta) -- a large Australian spider with a bite that is deadly to humans and insects -- is an ideal sou...is studying the molecular structures of the toxins that selectively target the nervous systems of insects to understand the toxins' mechanism of action at t...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
A special type of MRI scan that measures the flow of water molecules through the b...n map. They used a magnetic resonance imaging scan that tracks the diffusion, or movement, of water through the brain and mapped the changes in diffusion fr...Gene variations explain drug dose required to control seizures
...drugs appropriate for them. The researchers found that variants of two genes were more likely to be found...ians to reach an effective dose of the medications that control seizures, said David Goldstein, Ph.D., director of the IGSP Center at Duke University Medica...Solution to Pollution: New Bacteria Eats Toxic Waste
...ity researchers recently discovered a new bacteria that is a natural cleanser for contaminated soil. The b...il analysis tests, Sims found microbes in the soil that had destroyed the toxic chemicals. Sims then collaborated with researchers from the Utah State biol...Scientists collaborate to assess health of global environment
...tries participated in the assessment and concluded that the environmental benefits that human societies depend on and take for granted--basic necessities such as food, clean air, potable w...