Jefferson Virologists Coax HIV Out of Hiding
...ledinterleukin-7 (IL-7) can rouse the virus better than previously triedagents, making it vulnerable to dr...ail usinga combination of drugs. “We may need more than one drug to stimulatevirus from latency, similar to using HAART to stop replication,?hesays, referri...Novel Therapy Tested in Mice Could Chase Away Cat Allergies
...to all the blood cell cultures. “We measured more than 90 percent less histamine in the cultures with GFD,?says Dr. Saxon. “Those results suggested that GFD successfully prevented the immune cells from reacting to cat allergen. The next step was to test GFD in mice that we had made allergic to the allerg...Color-blind method opens new doors in DNA sequencing
...f doing DNA sequencing that could be more accurate than current methods. DNA in the nucleus of every huma...ker is also seeking to develop a chip-based imager than could be used in his overall project on sequencing-by-synthesis (SBS), which is funded by the Nation...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...DR* study inthe year 2000 that documented a higher than usual rate of autismspectrum disorder and explored its link to bromoform, chloroform, andtetrachloroethylene in Brick's water supply--it got her thinking. "Myhypothesis was this: While it had been proven that individually thechemicals don't impact ne...Female sex hormones play a vital role in defense against sexually transmitted diseases
...tive for HSV-2 and women are much more susceptible than men. "The results directly indicate that the horm...transmitted viral infections may be very different than those that may be useful in vaccination strategies," said Kaushic. "There is of course the flip sid...Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
...ng cancer currently has a poor prognosis with less than 15 percent of patients surviving five years. The lungs, however, are relatively accessible for inhalation of potential gene therapy agents. "While this is not likely to cure the cancer," said Slack, "after diagnosis, gene therapy with let-7 may be a ...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...DR* study inthe year 2000 that documented a higher than usual rate of autismspectrum disorder and explored its link to bromoform, chloroform, andtetrachloroethylene in Brick's water supply--it got her thinking. "Myhypothesis was this: While it had been proven that individually thechemicals don't impact ne...Mouse brain tumors mimic those in human genetic disorder
... tumors generally start growing inchildren younger than 5 years old and usually do not progress after age10. A similar pattern occurred in the mice: The optic nerve and chiasmwere enlarged and astrocytes along the optic pathway began multiplyingand growing when the animals were around three weeks old, dev...New Clues Add 40,000 Years to Age of Human Species
...from near the town of Kibish, are far more ancient than researchers originally suspected and nearly 40,000 years older than skulls from Herto, Ethiopia, the previous record holders. The Kibish hominids—dubbed Omo I and Omo ...A bacterial genome reveals new targets to combat infectious disease
More than a billion people are at risk for infection with fi...blindness, and other debilitating diseases in more than 150 million people worldwide. The nematodes themselves play host to bacteria that live within their ...Spider Venom Could Yield Eco-Friendly Insecticides
...ce Australian funnel-web spiders can live for more than five years in captivity, a small group of these sp... Funnel-web spider venom is a complex brew of more than 100 chemical compounds, most of which are toxic to insects, but not vertebrates. King is studying th...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
...responded to the therapy. After three weeks ?more than two months before the final MRI scan ?researchers found significant differences between the patients' scans. Some areas reflected an increase in water diffusion, suggesting tumor cell death; other areas saw a decrease in diffusion, which Ross said co...Scientists collaborate to assess health of global environment
...New Delhi, Brasilia, Cairo, Nairobi and Rome. More than 2,000 scientists from 95 countries participated in...the state of the global environment, but it's more than that," said Harold A. Mooney, the Paul S. Achilles Professor of Environmental Biology at Stanford Un...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...earch. Several forms of Pompe disease affect more than 5,000 people in the U.S. If symptoms appear during infancy, the disease is usually fatal. Those for whom symptoms first appear late in childhood live longer, but life expectancy remains greatly decreased. Although Pompe disease is a relatively rare d...Scientists decipher genome of fungus that can cause life-threatening infections
...affect humans. TheScience study identified greater than 30 new genes likely involved incapsule biosynthesi...ethat the differences likely involve other factors than the absence orpresence of individual genes in the two isolates. A combination ofother factors ?perha...Needling Chromosomes Reveals Cell Division Secret
...th sister chromatids can go to the same polerather than to opposite poles. This creates chromosome imbalances thatcan lead to cancer or chromosomal abnormalitiesthat cause birthdefects."According to Nicklas, it was known that the two sister chromatidsadhered to one another and released at the appropriate ...Poplar trees redirect resources in response to simulated attack
...abeled sugar and delivered more of it to the roots than plants untreated with the hormone. "This is pretty convincing evidence that plants can respond 'passively' by redirecting their nutrients away from the site of attack and placing them into storage for later regrowth," Ferrieri said. Supporting evide...Purdue proves concept of using nano-materials for drug discovery
...e goal is to produce "laboratories-on-a-chip" less than a half-inch square that might contain up to a mill...ns," Lee said. The alumina contains pores smaller than 100 nanometers, and the total volume of the reactors varies from 1-10 nanoliters. "What's unique ab...Scientists discover the cellular roots of graying hair
...Bcl2. Thesemice also went gray, but more gradually than did the mice that had noBcl2. The loss of MITF activity, the investigators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?depletion. MITF, they conclude, seemsto play a crucial rol...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
...Bcl2. Thesemice also went gray, but more gradually than did the mice that had noBcl2. The loss of MITF activity, the investigators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?depletion. MITF, they conclude, seemsto play a crucial rol...