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Tag: "testicular" at biology news

Reversing cancer cells to normal cells

... also report Nodal expression in breast cancer and testicular cancer) regain the ability to express a potent embryonic morphogen like Nodal, the presence of the Nodal and the signals it sends and receives appear to play a key role in tumor cell plasticity and progression. Most noteworthy, Dr. Hendrix’s tea...

Firefighters face increased risk for certain cancers

..., that firefighters are twice as likely to develop testicular cancer and have significantly higher rates of non-Hodgkin's lymphoma and prostate cancer than non-firefighters. The researchers also confirmed previous findings that firefighters are at greater risk for multiple myeloma. Grace LeMasters, PhD, Ash ...

Exposure to dioxins influences male reproductive system, study of Vietnam veterans concludes

...most 50 percent, a three- to four-fold increase in testicular cancer, an increase in the incidence of cryptorchidism (undescended testes, a condition where the testes are not in their normal location in the scrotum) and hypospadias (abnormality of the urethra). The reason for this increase is not known, but...

Spike in testicular cancer is focus

...inpointing reasons behind the dramatic increase in testicular cancer, now the most common malignant cancer among...ronmental hormone disruptors increases the risk of testicular cancer. They will measure the levels of these environmental compounds in 800 patients with testicula...

Human testis harbors HIV-1 in resident immune cells

...t on cells located within the testis, specifically testicular macrophages. The point was demonstrated further...e. The finding that HIV-1 can replicate within testicular macrophages is significant because the testis represents a pharmacological sanctuary—many anti-retro...

Injection may prevent infertility in men receiving cancer chemotherapy

...d to investigate whether it could be used to avoid testicular damage in mice treated with Taxol. "Clinical stud...hat a single dose of Taxol had induced significant testicular weight loss compared with the control group. An injection of AS101 a day before that of Taxol preve...

One big biology question solved

...ch has suggested a possible cause for these common testicular cancers, opening up avenues of investigation which will hopefully one day lead to a cure," Professor Koopman said. The findings of the team will be published in one of the world's top scientific journals Science and will be available in its online ...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

...drug that is given for the treatment of metastatic testicular or ovarian cancers, and some advanced bladder cancer, and is a very effective drug in combination with other therapies. However, according to Farrell, these current agents have limited activity against many common human cancers, and they are suscep...

Basic research leads to a novel cancer therapy

...an cancer, pancreatic cancer, prostate cancer, and testicular cancer. The studies are in various stages of clinical trials (phases I through III), and most of them are being carried out in combination with other therapies. Ullrich is very pleased with the quick approval of SUTENT®. He says, "Already before app...

Study hints at role of stem cell genes in testicular, breast cancers

...f several embryonic stem cell genes is elevated in testicular and breast cancers, providing some of the first mo...tumors that account for 50 percent of the cases of testicular cancer, the most frequent cancer in Caucasian males ages 15-40 -- and breast cancers, as represented...

Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory

...es, infertility and possibly cancer (in particular testicular cancer). By developing suitable tests with embryonic stem cells as they differentiate to germ cells we can investigate the action of these chemicals in the laboratory. "Ultimately it might be possible to produce sperm and eggs for use in assisted co...

Researchers discover mechanism for multiplying adult stem cells

...ugh Oct4 is known to be active in certain forms of testicular and ovarian cancer. Still, the most provocative finding was that "Oct4 causes tumors by preventing adult stem cells in these tissues from differentiating," says Hochedlinger. In other words, with Oct4 active, the stem cells could replicate themselves...

How the environment could be damaging men's reproductive health

...ndescended testes are at higher risk of developing testicular cancer between the ages of about 20 and 40, and of...problems. Cryptorchidism is one of the symptoms of testicular dysgenesis syndrome (TDS) ?a collection of male reproductive disorders, possibly caused by errors in...

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