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Tag: "terminal" at biology news

Ancient DNA traces the woolly mammoth's disappearance

...t have been responsible for killing off the small, terminal populations that were left.” Barnes, along with Dr. Adrian Lister of the University College London and the Natural History Museum in London and others, had earlier found evidence that bison, bears, and lions underwent major population shifts twent...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

... had been released or escaped from the island, his terminal condition would have prevented him from playing a further major role in the theater of European history," said Dr. Robert Genta, professor of pathology and internal medicine at UT Southwestern and senior author of the study. "Even today, with the ava...

Weighty viruses

...l, optimized the geometry, and exchanged the usual terminal electrodes of the cylinder with transparent, electrically conducting plates. This special construction is what made application of the precise light-scattering technique for the mass determination of a single virus possible. ...

UGA scientists unravel 'molecular inch-worm' structure of walking-pneumonia bacterium

... species such as M. pneumoniae posses this complex terminal organelle. We've been able to observe it in growin...nd others have been increasingly interested in the terminal organelle that develops on one end of M. pneumoniae because it is involved in cell division, adheren...

A single sugar found responsible for an antibody's ability to treat inflammation

...nts. That's how they discovered that just the very terminal sialic acid on the Fc portions of the IgG molecule were the root of the anti-inflammatory activity. When the researchers removed the sialic acid, the molecule retained its structure and its half-life, but it lost its protective abilities. "This is a...

Protein receptor cools passion of 'kiss and run' nerve cells

...n out to be 5-HT. "When you release 5-HT onto the terminal (pre-synaptic) cell, you can switch the relative activation of different receptors on the post-synaptic cell," he said. "You don't just change the amount of neurotransmitter released, but you change what's activated -- the balance of different things...

The giant protein titin helps build muscles

.... The groups will now look for other examples. The terminal assembly complex investigated in this work, though, only covers a tiny part of the giant muscle protein titin, which possesses tens of thousands of amino acids in some isoforms. "There are probably hundreds or even thousands of more interactions down...

Chemical guidance of T cells leads to immunologic memory and long-term immunity

...ntrate. Think of the lymph node as a large airport terminal and the CD8+ T cells as the arriving passengers, says Dr. Germain. If passengers know that limo drivers will meet them in the terminal, they will look for their drivers upon arrival. Rather than hoping to run into each other by chance, the drivers cr...

Minor mutations in avian flu virus increase chances of human infection

...complex glycans-carbohydrates-that in turn contain terminal sialic acids. Avian viruses prefer binding to ?2-3-linked sialic acids on receptors of intestinal epithelial cells, while human viruses are usually specific for the ?2-6 linkage on epithelial cells of the lungs and upper respiratory tract. Such inter...

How E. coli bacterium generates simplicity from complexity

...inal electron acceptor. "We found that the type of terminal electron acceptor in the growth environment and the presence or absence of glucose is very important to E. coli," said Barrett. "Our simulations show that these two factors are key determinants of how the bacterium organizes itself." Barrett, Palsso...

The nude mouse tale: Omega-3 fats save the life of a terminal cancer patient

...lped the 78-year-old after D.H. was diagnosed with terminal lung cancer. "In 2000 he was told by his doctor he had only a few months to live," said Pardini, a professor of biochemistry and associate director of the Nevada Agricultural Experiment Station at the University of Nevada, Reno. "But five years lat...

Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

... fibers. "It actually seems to work better in the terminal (striatum)," Svendsen says. "The bonus is it gets transported back to the substantia niagra." The transplanted cells, according to Behrstock, survived and continued to produce GDNF in laboratory animals for up to three months. One hurdle that needs...

Anti-cancer drugs may hold promise for premature aging disorder

...in the protein signals an enzyme to cleave off the terminal portion of the protein, including the farnesyl group, freeing lamin A to integrate properly into the nuclear lamina. Because progerin carries the farnesylation tag but lacks the second cleavage tag, Capell speculated that progerin was becoming perm...

Biotechnology's newest chemical tool

...large native DNA molecules at specific internal or terminal loci," Klimasauskas explained. While potential applications are many, the researchers next plan to synthesize new AdoMet analogs to expand the collection of chemical groups that can be transferred to DNA by methyltrasferases. Klimasauskas's group i...

Scientists use gene transfer technology and common virus to block neuropathic pain

...related HSV vector in patients with pain caused by terminal cancer, which has spread to bone. ...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...related HSV vector in patients with pain caused by terminal cancer, which has spread to bone. The research was supported by grants from the National Institute of Neurological Disorders and Stroke and the Department of Veterans Affairs. Additional collaborators in the study included Darren Wolfe, Ph.D. and Jo...

Compound might defeat African sleeping sickness, clinical trial beginning this month

... in the local villages before it progresses to the terminal brain stage," the physician said. "When a drug works and helps a lot of people, that's when all our hard work really pays off, and we can be proud of our efforts." Three years ago, the National Foundation for Infectious Diseases presented its Jimmy ...

Chimp genome reveals a retroviral invasion

...l, and env -- and regulatory sequences called long terminal repeats (LTRs). To further explore the evolutionary history of the retroviral elements, the authors compared the sequences of gag and pol, as well as the LTR sequences, for each infected primate species. The sequence history, they discovered, did not...

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