telomeres 2 1

Tag: "telomeres" at biology news

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...venessof a promising cancer treatment that targets telomeres in an attempt tointerfere with the ability of a ca...k properly andthe cell stops dividing. In a sense, telomeres function as a kind ofcounting mechanism that regulates how many times a cell can divide.In contrast ...

GATA: a graphic alignment tool for comparative sequence analysis

...venessof a promising cancer treatment that targets telomeres in an attempt tointerfere with the ability of a ca...k properly andthe cell stops dividing. In a sense, telomeres function as a kind ofcounting mechanism that regulates how many times a cell can divide.In contrast ...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

...main of telomerase, the enzyme that helps maintain telomeres ?small pieces of DNA on the ends of chromosomes th...es, get shorter. In the natural aging process, the telomeres eventually get so short that cells can no longer divide, and they die. While telomerase is turned of...

Two chemicals boost immune cells' ability to fight HIV without gene therapy

...ous research shows that telomerase rejuvenates the telomeres and allows the immune cells to remain youthful and active as they replicate under HIV's attack. Drugs that activate telomerase also offer therapeutic potential for a wide spectrum of degenerative diseases and chronic conditions in which cellular agin...

Tiny roundworm's telomeres help scientists to tease apart different types of aging

...ans succumbs to the trials of old age although its telomeres are still long, and moves with a youthful spring i...gy Laboratory, provide a much more nuanced view of telomeres and the process of cellular and organismal aging. "Some long-lived species like humans have telomer...

Normal chromosome ends elicit a limited DNA damage response

...ent the cell's DNA repair machinery from confusing telomeres with broken strands of DNA that need to be repaire...sponse machinery ?recruited by the now unprotected telomeres - congregate at the tips of chromosomes. "We believe that the localization of repair proteins to c...

A little telomerase isn't enough

...n't enough. In these "half-telomerase" mice, their telomeres shortened over time, bringing an early demise to s...er. "These mice develop disease only because their telomeres are short, and having telomerase doesn't lengthen them right away." The condition of the mice is vi...

New mechanism for essential genome-wide gene silencing identified

... maintaining genomic stability. Instability in the telomeres has been linked to aging in humans and an elevated risk for aging-related diseases, the most prominent of which is cancer. ...

Groovy protein essential for promoting cancer development

...t healthy adult cells, telomerase is shut off, and telomeres slowly shrink during cell division ?a normal proce... on, achieving a dangerous immortality. "Getting telomeres replicated again is required for carcinogenesis to proceed," Cech explained. "It's an essential step...

Report lists top 20 most-vulnerable African carnivores

...t healthy adult cells, telomerase is shut off, and telomeres slowly shrink during cell division ?a normal proce... on, achieving a dangerous immortality. "Getting telomeres replicated again is required for carcinogenesis to proceed," Cech explained. "It's an essential step...

Aging cells, aging body: Fresh evidence for a connection

...signals that the protective chromosome caps called telomeres have dwindled enough to halt cell division. Scien...e and blood vessels. "This research confirms that telomeres are important in aging," he said. "But we've only scratched the surface. Now that we've come up with...

DNA end caps may lead to cancer treatments, UT Southwestern researchers report

... called telomeres. Each time the cell divides, the telomeres shorten. When they become too short, the aging cel...ancer cells, an enzyme called telomerase keeps the telomeres from shortening, making the cells immortal and potentially malignant. "Drugs that influence these ...

New target for cancer therapy identified

... life span of cells by modifying structures called telomeres that are found at the end of chromosomes. Althoug.... It is plentiful in stem cells where it keeps the telomeres long, allowing the cells to keep dividing without limit which is necessary for the repair of damaged...

Regulating the nuclear architecture of the cell

...nd at the ends of a chromosome, where it abuts the telomeres -- chromatin structures best known for limiting, by their diminishing length, how many times a cell can replicate. Heterochromatin also flanks the centromere in the central region of the chromosome, the chromatin structure that plays a crucial role i...

New clues to how sex evolves

...pecies -- plants, mammals, fungi, and so on - the telomeres on the ends of the chromosomes anchor to the nuclear membrane in a transient structure called a 'meiotic bouquet,'" Dernburg says. "In C. elegans it's the Pairing Centers, not telomeres, that attach to the nuclear envelope. They do so seemingly rando...

Short chromosomes put cancer cells in forced rest

...of chromosomes, called telomeres. "Normally, when telomeres get critically short, the cell commits suicide as ...the researchers discovered that the mice had short telomeres and stopped developing lymphomas. When the researchers blocked the suicide machinery in these fi...

DNA ends: Common tool, different job

...lk Institute. With each round of cell division, telomeres ?long stretches of repetitive DNA ?erode a little ...cal clock that winds down over time. In fact, when telomeres reach a "critical length," the cell can no longer multiply ?a characteristic sign of cellular senesc...

Researchers attach genes to minichromosomes in maize

...ereas a chromosome is made of both centromeres and telomeres with much intervening DNA, a minichromosome contains only centromeres and telomeres, the end section of a chromosome, with little else. However, minichromosomes have the ability to accept the addition of new genes in subsequent experiments. Birchl...

1