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Tag: "telomere" at biology news

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...ibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a telomerase inhibit...of drug treatment that isrequired for the onset of telomere crisis and reduce the potential riskof acquired drug resistance, " writes Dr. Seimiya.Hiroyuki Seimi...

GATA: a graphic alignment tool for comparative sequence analysis

...ibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a telomerase inhibit...of drug treatment that isrequired for the onset of telomere crisis and reduce the potential riskof acquired drug resistance, " writes Dr. Seimiya.Hiroyuki Seimi...

Tiny roundworm's telomeres help scientists to tease apart different types of aging

...cs, available online now. In the past, preventing telomere shortening has often been portrayed as the key to ... C. elegans is the perfect model organism to study telomere biology since their regulation is similar to human telomeres," says first author Marcela Raices, a p...

A little telomerase isn't enough

...ese animals turns out to be the animal's inherited telomere length, not the status of the telomerase gene, say...eres. "We know it only takes one critically short telomere to make a cell die, so it's clear that the more really short telomeres a person has the faster probl...

Aging cells, aging body: Fresh evidence for a connection

...cative senescence, the most important biomarker is telomere dysfunction-induced foci, or TIFs. Presence of these structures signals that the protective chromosome caps called telomeres have dwindled enough to halt cell division. Scientists painstakingly counted the cells with aging biomarkers. What they foun...

DNA end caps may lead to cancer treatments, UT Southwestern researchers report

... biology. In human cells, every chromosome has a telomere at each end, and each telomere ends in a single-stranded overhang. (DNA is normally double-stranded.) The overhang at one end of th...

Osteoarthritis may be sign of faster 'biological ageing'

...nsurprisingly, the findings showed that white cell telomere lengths were associated with chronological age. Th...among the 160 people with hand osteoarthritis, the telomere length was significantly shorter than among those without the disease, even after taking account of ...

Exploring the dark matter of the genome

...o see is a complete sequence of the fruit fly from telomere to telomere" -- that is, from one end of the chromosomes to the other -- including the centromere in the middle." Obtaining a more complete picture of the sequence of heterochromatin is clearly a crucial step toward a better understanding of genome f...

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