Tag: "telomerase" at biology news

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...reoften very different in reality. Its the case of telomerase inhibitorsto treat cancer; they are supposed to st...ity andtelomere shortening decrease the effects of telomerase inhibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a telom...

GATA: a graphic alignment tool for comparative sequence analysis

...reoften very different in reality. Its the case of telomerase inhibitorsto treat cancer; they are supposed to st...ity andtelomere shortening decrease the effects of telomerase inhibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a telom...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

... are replicated. This is the first major piece of telomerase for which the structure is known. Telomerase plays... of the structure should provide insights into how telomerase works," said Juli Feigon, professor of chemistry and biochemistry at UCLA, who led the research grou...

Two chemicals boost immune cells' ability to fight HIV without gene therapy

...earch demonstrates that the new chemicals activate telomerase -- a protein that boosts immune cells' ability to ..."The immune cells that fight HIV naturally produce telomerase during the infection's early phase, but stop once HIV becomes a chronic condition," explained Rita E...

Engineered skin offers clues to melanoma development

...act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that pro... scientists also investigated the role of elevated telomerase activity. In combination with other cancer genes, hTERT, the active protein in the enzyme telomerase...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that pro... scientists also investigated the role of elevated telomerase activity. In combination with other cancer genes, hTERT, the active protein in the enzyme telomerase...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that pro... scientists also investigated the role of elevated telomerase activity. In combination with other cancer genes, hTERT, the active protein in the enzyme telomerase...

Nanowires can detect molecular signs of cancer, scientists find

...s, these receptors allowed real-time monitoring of telomerase binding and activity. Lieber says nanowire arrays could easily be scaled up to detect many different cancer markers -- more of which are being found all the time, thanks to the current boom in proteomics. Widespread use of these cancer markers in he...

Discarded placentas deliver researchers promising cells similar to embryonic stem cells

...ir advantage that the amnion epithelial cells lack telomerase expression, because telomerase is associated with many cancers and one of the main concerns about stem cell therapies is that trans...

Master regulatory gene found that guides fate of blood-producing stem cells

...ng HSC fate-for example homebox, wnt, notch 1, and telomerase genes. Emerson and colleagues figured that one transcription factor, called NF-Y, was required for activating promoters of all of these genes. What's more, they found that fully assembled NF-Y was activated in stem cells and disappeared when the stem...

A little telomerase isn't enough

... exposed. In stem cells, however, a protein called telomerase normally maintains the telomeres' length, allowing... engineered to have just half the normal amount of telomerase can't maintain their stem cells' chromosome ends, showing that a little telomerase isn't enough. In ...

Groovy protein essential for promoting cancer development

...he detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast major... ends of chromosomes. In most healthy adult cells, telomerase is shut off, and telomeres slowly shrink during cell division ?a normal process that helps limit cel...

Report lists top 20 most-vulnerable African carnivores

...he detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast major... ends of chromosomes. In most healthy adult cells, telomerase is shut off, and telomeres slowly shrink during cell division ?a normal process that helps limit cel...

DNA end caps may lead to cancer treatments, UT Southwestern researchers report

...divide. But in most cancer cells, an enzyme called telomerase keeps the telomeres from shortening, making the cells immortal and potentially malignant. "Drugs that influence these mechanisms might be used to slow replicative aging in normal cells and increase the efficacy of telomerase-inhibition therapies fo...

Targeted virus compels cancer cells to eat themselves

...o says. ''Once the virus enters the cell, it needs telomerase to replicate. Normal brain tissue does not have te...d colleagues showed that hTERT-Ad (short for human telomerase reverse transcriptase promoter regulated adenovirus) infected the glioma cells and induced autophagy...

New target for cancer therapy identified

... stopping the gene from producing a protein called telomerase that is essential if cancer cells are to prolifera...s. Although it is involved in tumour development, telomerase is also found in modest quantities in most cells. It is plentiful in stem cells where it keeps the t...

Short chromosomes put cancer cells in forced rest

...e research team first mated mice with nonoperating telomerase to mice carrying a mutation that predisposed them ...st generation pups born to these mice contained no telomerase and very long telomeres. These mice all developed lymphomas by the time they were 7 months old. The ...

DNA ends: Common tool, different job

...hich need to divide indefinitely, an enzyme called telomerase elongates telomeres to compensate for the continual attrition at chromosome ends. At the same time, telomerase activity is the main mechanism by which human tumor cells achieve immortal growth. In addition, t...

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