UCSD researchers create roadmap to integrin activation
... A signal from inside the platelet to the outside tells the GPIIb-IIIa integrin on the cell's surface to get sticky. Direct inhibitors of GPIIb-IIIa binding include antithrombotics such as eptifibatide (Integrelin), abciximab (Reopro), and tirofiban (Aggrestat), drugs that reduce thrombosis, or formati...Mayo discovers protein as potential tactic to prevent tumors
...itching it on as the initial link in a signal that tells the cell to set itself up for apoptosis. CDK2 adds phosphorylation to a specific serine residue on the chain of amino acids that make up FOXO1. In case of robust errors found in the genetic code, CDK2 signals FOXO1 to explicitly call for the cell to ...Geneticists discover genes that make fruit fly hybrids sterile
...enes interfere with each other in hybrids. "This tells us there must be other things involved in the hybrid" that impacts the incompatible pairing of these genes, said Barbash. In future work the researchers hope to determine whether the hybrids die because of additional genes like Hmr and Lhr, or becaus...Teenager moves video icons just by imagination
... able to look at age differences and see what that tells us about the brain," said Moran, who said the team plans to test more pediatric subjects. "No one has ever seen if brain signals from children are different. We'll try to determine if teenagers have different frequency distributions when their cortex...Fast-freeze snapshot yields new picture of nerve-muscle junction
... in places scientists have never before seen. "It tells us that specific proteins are required to transition vesicles in close apposition to pre-synaptic membranes," said Richmond. "That prediction had been made, but hasn't before been demonstrated." Richmond said the conventional gluteraldhyde fixation ...Genome archaeology illuminates the genetic engineering debate
Genome Research's cover story for Oct. 2 tells a tale of "genome archaeology" by genetic researchers who dug deeply into the long history of maize and rice. Their resulting insights into plant genomic evolution may well fuel the fires of the genetically modified organism (GMO) controversy. "Our...Tiny Tampa Bay fish key to evolution of immune system
...ture Immunology. "At a basic level, this sea worm tells us about the evolution of the immune response; specifically, it tells us that primitive organisms have more sophisticated immune systems than we previously thought," said...Math model predicts cancer behavior
...pository of data that is put together; it actually tells you which variables are the important ones and gives outcomes that you wouldn't have otherwise predicted." The current model predicts that in mild environmental conditions ?imagine a lush rainforest, Quaranta said ?many cell types co-exist and the ...Negative effects of caffeine are stronger on daytime sleep than on nocturnal sleep
...override the signal from the biological clock that tells the body it should be awake at this time of day," explains Dr. Carrier. "We often use coffee and other sources of caffeine during the nighttime to counteract sleepiness generated by sleep deprivation, jet lag, and shift-work. However, this habit may ...How does your brain tell time?
...to understanding speech, determining how the brain tells time represents an important step toward understanding the causes of diseases, such as dyslexia, that result in impaired linguistic abilities, he noted. The next step for the research will be recording the response from a large number of brain cel......decades that the neurotransmitter glutamate, which tells neurons to fire, can also destroy them. If over-activated, glutamate receptors start a chain reaction that raises the concentration of calcium and activates calpain, among other toxic enzymes. But Baudry and Xu observed that in one receptor, mGluR...Genes and genius: Researchers confirm association between gene and intelligence
...ould have to put those pictures into an order that tells the story of how the child dropped the vase and broke it and then cried." The researchers studied DNA gathered as part of the Collaborative Study on the Genetics of Alcoholism (COGA). In this multi-center study, people who have been treated for al...US conservation efforts bring more marine turtles to UK
...lace in the United States and Mexico. ‘The data tells the story of the interaction between marine turtles and humans over the last hundred years,?said Matthew Witt of the University of Exeter. ‘Following a severe decline as a result of human activity in the first-half of the last century, we can now see...New dopamine brain target discovered
...ificant implications for schizophrenia. Research tells us that people with schizophrenia may have disordered calcium signals, and the major treatments for this disease target the dopamine system. Drs. George and O'Dowd state, "our data links these two pieces of evidence, creating better understanding of ...Salamanders suffer delayed effects of common herbicide
...gical Survey in St. Louis, Missouri. "What this tells me is that we need to consider the long-term effects of chemicals, and that exposure to atrazine during formative stages might have permanent effects on these salamanders that increases their risk of mortality," he added. While the mechanism by wh...Mosquito genes explain response to climate change
...mosomes also have overlapping gene expression that tells the species to go dormant, which they must do to survive. "This chromosomal map is drawing a lot of interest in terms of understanding the genetic response of animals to rapid climate change and also to understanding the metabolic processes invol...Carnegie Mellon University research shows how sensory-deprived brain compensates
...he Neural Basis of Cognition (CNBC). "This finding tells us that brain function is plastic, or reparable, w...iments was striking, Barth says. "What this tells us is that the parts of the brain processing sensory information are extremely adaptive and can stre...Research finds music training 'tunes' human auditory system
... and neocortex is a dynamic and reciprocal one and tells us that our basic sensory circuitry is more malleable than we previously thought." Overall, the findings assist in unfolding new lines of inquiry. The researchers now are looking to find ways to "train" the brain to better encode sound ?work that...Newborn brains grow vision and movement regions first
...ewborns who were included in the study. "What that tells us is that the overall asymmetries in the adult brain occur because of developmental events that happen after birth," Gilmore said. "So unlike the gender differences, the asymmetry differences arise after a baby is born." For the study, 74 newborns...Glucose triggers brain cell death in rats after hypoglycemic coma
... essential to memory and cognition. "This study tells us for the first time that, in rats, the brain damage occurs not during the coma, but after it, when we give them glucose and their blood glucose levels return to normal," says principal investigator Raymond A. Swanson, MD, chief of the neurology and...