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Tag: "targets" at biology news

Stroke treatment a step closer after trial

...t the treatment may help to salvage. "The protein targets the molecule that causes inflammation and dramatically reduces the inflammatory markers," said Professor Rothwell, MRC Research Professor and the University's Vice-President for Research. "In the laboratory we were able to reduce damage to the cells...

Clocking in Pillow Time without the Pillow

...d. The ubiquity of these receptors makes them good targets for drugs that increase general cognitive functioning. The researchers used a technique called positron emission tomography, or PET, to gain insight into CX717's neurobiological role. The PET signal reflected the distribution and rate of metabolism ...

Noise And Delays Explain Why Some Genes Oscillate In Activity

...d. The ubiquity of these receptors makes them good targets for drugs that increase general cognitive functioning. The researchers used a technique called positron emission tomography, or PET, to gain insight into CX717's neurobiological role. The PET signal reflected the distribution and rate of metabolism ...

Gene Expression in the Aging Brain

...k of genetic changes in aging, and may even reveal targets for treatment of neurodegenerative diseases. ...

Navigating the brain for sense of direction as paradigm for higher cognitive functions

...k of genetic changes in aging, and may even reveal targets for treatment of neurodegenerative diseases. ...

Carnegie Mellon scientists create PNA molecule with potential to build nanodevices

...k of genetic changes in aging, and may even reveal targets for treatment of neurodegenerative diseases. ...

Discovering the first steps in transcription-coupled repair

...amage. Transcription-coupled repair is unique: it targets repair to genes that are actively being transcribed into messenger RNA. TCR was discovered about 20 years ago as a result of comparing the properties of cells from patients with Cockayne Syndrome (CS) versus those with xeroderma pigmentosum (XP), two...

Telling axons where to go - and grow

...cant decrease in axon length. Finding that Rnf6 targets LIMK1 for degradation finally closes this circle of regulation, providing the link between actin dynamics, axonal growth and Rnf6. Importantly, the authors are able to show that changes in axon outgrowth induced by changes in levels of Rnf6 can be r...

Finding the mind's eye

...awareness, and visual masking of simple unattended targets are confined to areas in the occipital cortex beyond human V1/V2," is available in the Nov. 8 issue of the weekly journal, The Proceedings of the National Academy of Sciences. Tse's findings help to explain what part of the brain is at work in turnin...

Switching to new anti-bacterial targets: Riboswitches

...witches may be a good hunting ground for effective targets against bacterial infection, according to a report by Yale researchers in the journal Chemistry and Biology. Riboswitches are RNA elements that control gene expression in essential metabolic pathways. Researchers in the laboratory of Ronald R. Brea...

Cancer support cells may evolve, fuel tumor growth, study shows

...nti-tumor therapies may be more effective if their targets are broadened to include molecules within supporting cells of the cancer.These additional target cells are in the tumor's surrounding "microenvironment," or stroma, including the supporting connective tissue that forms the framework of organs such as...

Genes involved in biofilms

..., and is an advance in the race to identify action targets for the development of pharmaceutical drugs to combat these infections. The PhD, entitled Identification and characterisation of new factors involved in the processes of formation of biofilm from Gram-positive bacteria. Chronic infections Bio...

Bacteria that cause tooth decay able to survive without important biochemical pathway

...ey said the YidC2 and the SRP pathway could become targets in fighting tooth decay because they have been shown to enable S. mutans to grow in acidic conditions. Additionally, the YidC molecule has been demonstrated to be important to bacterial virulence and growth and has the potential to become a target in...

NIH launches comprehensive effort to explore cancer genomics

...me Sequencing Centers. The genes and other genomic targets identified will be sequenced by the Cancer Genome Sequencing Centers using high-throughput methods similar to those employed in the Human Genome Project. The Cancer Genome Atlas Pilot Project seeks to identify genetic mutations in the DNA code that a...

Researchers develop new method to help find deadly malaria parasite's Achilles heel

...hat could lead to the identification of novel drug targets for fighting malaria," said John Whitmarsh, acting director of the Center for Bioinformatics and Computational Biology at the National Institute of General Medical Sciences, which partially funded the work. "Ideker and his team have demonstrated the ...

Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool

...e cell cycle system, which in turn can lead to new targets for cancer drugs," said Bar-Joseph. The new method also overcomes synchronization loss, a vexing problem for scientists who study hundreds or thousands of cells over time, according to Bar-Joseph. Large groups of living cells that start out together...

Open Source Biotechnology alliance for international agriculture

...break monopolies and foster fair competition. BiOS targets parallel challenges that limit the effective use of modern life sciences in agriculture to only a few multinational corporations. "New technologies are increasingly tangled in complex webs of patent and other legal rights, and are usually tailored f...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...ound is that one of the hepatitis C virus proteins targets a cell protein that is crucial for suppressing the development of tumors, interfering with its ability to control cell proliferation," Lemon said. "By knocking out this 'tumor suppressor' and promoting the proliferation of liver cells, this viral pro...

UCLA scientists discover immune response to HIV differs, even in identical twins

...irus invades a body, the cellular immune response targets small parts of proteins in the virus. This targeting mechanism itself is genetically determined. ". The virus tries to escape that immune response by mutating and changing shape. The twins' targeting of the HIV was remarkably similar 17 years after ...

Yale scientists decipher 'wiring pattern' of cell signaling networks

...es. Although protein kinases are already important targets of cancer drugs including Gleevec and Herceptin, u...housands of different proteins in a yeast cell for targets of the protein kinases. The 82 unique kinases, representing the majority of master regulators in the...

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