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Tag: "targets" at biology news

NHGRI Selects 13 More Organisms for Genome Sequencing

...vision of Extramural Research. The first group of targets consists of nine mammals. Eight mammals will be se...er date. NHGRI’s process for selecting sequencing targets begins with two working groups comprised of experts from across the research community. Each of the ...

Possible treatment found for 'chemobrain'

...vision of Extramural Research. The first group of targets consists of nine mammals. Eight mammals will be se...er date. NHGRI’s process for selecting sequencing targets begins with two working groups comprised of experts from across the research community. Each of the ...

Scientists discover gene that controls speed of tuberculosis development

...ding the basic pathways of pathogenesis offers new targets and policies for disease prevention," notes Dr. Emil Skamene, Scientific Director of the Research Institute of the MUHC. "Academic hospitals such as the MUHC combine scientific research, technology and clinic expertise, enabling scientific breakthrou...

Two designer drugs hit same lung cancer target, but only one is effective

...ults add to growing evidence that mutations in the targets of designer drugs critically influence their effectiveness. Erbitux is an effective inhibitor of EGFR signals in colorectal cancer, which involves a normal, not mutant, EGFR molecule. "We now know of several groups of patients who benefit from thera...

Weight control protein may yield antiobesity drugs

...ulated by SH2-B may serve as potential therapeutic targets for the treatment of obesity and type 2 diabetes. "Because SH2-B sensitizes both leptin and insulin, action drugs that mimic or enhance SH2-B action may improve insulin and leptin sensitivity and have potential value in treatment of obesity and type...

Gradient guides nerve growth down spinal cord

... he said, "the other half is guiding them to their targets where they can make the right connections." "Understanding how the brain and the spinal cord are connected during embryonic development could give us clues about how to repair damaged connections in adults with traumatic injury or degenerative disor...

Researchers report breakthrough against world’s deadliest viruses

... both Ebola and Marburg. "In addition, the vaccine targets dendritic cells, which are the same cells that Ebola and Marburg attack," said Dr. Geisbert. "These cells are also important in generating a protective immune response. So the vaccine goes exactly where we want it to go." The study describes how Can...

Virus uses tiny RNA to evade the immune system

...s from spreading. Conveniently, the microRNA that targets T antigen is made late in the infectious cycle, just when T antigen is no longer essential for virus replication. Further experiments showed that cytotoxic immune cells were more likely to kill cells infected with a mutant virus that cannot make the ...

Cells direct membrane traffic by channel width

...assage. Success in doing so could have created new targets for drug therapies. However, it turns out, the am...ciples could provide new, effective pharmaceutical targets to control the channels to help treat disease. Study co-authors were group director Klaus Schulten ...

Researchers discover new tumor defense system

...Studies raise the possibilities of new therapeutic targets for cancer, such as those that may transport free fatty acids out of the tumor. Alternatively, free fatty acid levels in the blood could be used to help gauge the aggressive potential of a tumor. ...

Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation

...e inflammation with the hope of developing them as targets for the next generation of asthma drugs. Suspecting that a defect in antioxidant response exacerbates asthma severity, the team of researchers began looking into the genetic factors that might contribute to this deficiency. In 2002, Biswal’s lab dis...

MSKCC researchers uncover structure of key protein complex in cells

...E3 is a kind of chemical marriage broker, bringing targets close enough to SUMO to facilitate binding. "E3 a... roles of sumoylation may well provide us with new targets to inhibit the protein and therapeutic agents for cancer and other conditions in which SUMO is invol...

Rutgers to lead $52.7 million protein research program

... even discovered several potential antibiotic drug targets and drug screening assays for which we have submitted patents," Montelione said. "However, there are many protein families that still do not have known structural representatives." NIGMS has now funded four of the strongest pilot program centers, in...

Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases

...omponents of this exit pathway might be attractive targets for antiviral therapies for a variety of viruses. Blocking Rab9 may have significant side effects, but there are people who live without Rab9, Hodge explained. Although they have metabolic problems, they are generally able to control their condition...

Eliminating bacterial infections out of thin air

...n innate immune defenses, the study…introduces new targets for therapeutic immunomodulation." ### TITLE: HIF-1alpha expression regulates the bactericidal capacity of phagocytes View the PDF of this article at: https://www.the-jci.org/article.php?id=23865 ACCOMPANYING COMMENTARY: Title: HIF-1alpha: a mas...

Clean skies=faster global warming?

...n innate immune defenses, the study…introduces new targets for therapeutic immunomodulation." ### TITLE: HIF-1alpha expression regulates the bactericidal capacity of phagocytes View the PDF of this article at: https://www.the-jci.org/article.php?id=23865 ACCOMPANYING COMMENTARY: Title: HIF-1alpha: a mas...

Fighting malaria by manipulating mosquitoes' sense of smell

...ere with malaria mosquitoes' ability to find human targets and lure the insects to their death. Malaria is considered to be the most prevalent life-threatening disease in the world, with estimates of the number of new cases that range from 300 million to 660 millions cases per year. Current efforts to contr...

Study findings offer potential new targets for antibiotics

...t spots" on a ribosome that could act as potential targets for antibiotics ?the researchers first introduced ...id not know that these areas could possibly become targets for antibiotics. These sites are what may one day give pharmaceutical companies an edge in creating...

Volunteers sought for avian flu vaccine study

...g volunteers in a study to test a new vaccine that targets avian flu, the first such vaccine against the virus. The Vanderbilt trial, led by Kathryn Edwards, M.D., will test the new vaccine in nearly 100 individuals 65 years of age and over. It is the second phase of anational study led by the National Insti...

Grasshopper love songs give insight into sensory tuning

...others by launching bursts of neurotransmitters at targets on receiving neurons to produce nerve impulses in those targets. Neurons adjust the strength of those connections adaptively, to amplify or suppress connections. Some four decades ago, a general principle called the "efficient coding hypothesis" was ...

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