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Tag: "targets" at biology news

Biologists determine genetic blueprint of social amoeba

...makes Dictyostelium a better model for looking for targets against which drugs can act." Key collaborators in the project at Baylor included Richard Gibbs and George Weinstock, co-directors of Baylor's Human Genome Sequencing Center, and Richard Sucgang, an assistant professor of biochemistry. Baylor perfor...

Malaria killing a million a year

... The Millennium Development Goals (MDGs), a set of targets agreed at a UN summit in 2000 to halve or eliminate many socio-economic ills, would halt or reverse the spread by 2015, while WHO's Roll Back Malaria partnership, founded in 1998, aims to halve the burden by 2010, despite a serious lack of funds. On...

Scientists find microRNAs regulate plant development

...RNAs, and therefore have been considered potential targets of microRNA-mediated regulation. One of these targets is the transcription factor AUXIN RESPONSE FACTOR17 (ARF17), which is thought to repress the express...

Disease diagnosis, bioengineering covered at state nano summit

...drug to treat HIV, one of the diseases he actively targets with his research. ...

New lifespan extension genes found

...nimals including worms, flies and rodents. But the targets of these genes are likely to be different, as the toxic DNA circles have not been identified in more advanced organisms, Lin said. The work was published in the Sept. 16 issue of Science. ...

Most common lung cancers may begin in newly discovered cells

...del for identifying those cells that should be the targets of therapeutic intervention," wrote Anton Berns of The Netherlands Cancer Center in Amsterdam in an accompanying commentary in Cell. The identification of the cells could lead to earlier diagnosis of lung cancer in people. Lung cancer is the leading...

Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

...omes a little bit more greasy, and so the kinds of targets that it might interact with change completely.?/p> “We actually have in our hands now the ability to do things that a chemist might not be able to do, or if a chemist was able to do it, it could be expensive and time-consuming,?said Noel. “I thin...

Stem cell training program to make its Stanford debut

...omes a little bit more greasy, and so the kinds of targets that it might interact with change completely.?/p> “We actually have in our hands now the ability to do things that a chemist might not be able to do, or if a chemist was able to do it, it could be expensive and time-consuming,?said Noel. “I thin...

NIH creates nationwide network of molecular libraries screening centers

... disease, which is key to identifying possible new targets for diagnosis, treatment and prevention. To date, ...sease, and even to the identification of potential targets for new therapies. Central to this effort are the databases supporting the network, which will allow...

Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors

...he growth of normal cells," he said. "Chemotherapy targets all dividing cells ?not just those involved in cancer ?so it is highly toxic. Our hope is to provide the basis for less toxic, more targeted therapies." ...

Beyond genes: Lipid helps cell wall protein fold into proper shape

...embranes and their surface proteins are accessible targets for pharmaceuticals, and most drugs target either membrane proteins on human cells or the membranes of pathogens. Co-authors of the JBC paper with senior author Dowhan are first author Wei Zhang, Ph.D., a former graduate student who is now a post-do...

MicroRNA tweaks protein that controls early heart development

...esearchers discovered that a microRNA called miR-1 targets the mRNA of the gene Hand2, a key regulator of hea... in vertebrates there are only three or four known targets for those hundreds. "We are learning that microRNAs are a common mechanism through which a cell reg...

VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells

...uggests that sphingosine kinases are potential new targets in cancer therapy," she said. ...

Treatments have same target, different responses for lung cancer patients with genetic mutation

...ine the effectiveness of another type of drug that targets EGFR--a monoclonal antibody called cetuximab, whi...olorectal cancers that overexpress EGFR. Cetuximab targets EGFR by preventing its activation by extracellular signals, or signals occurring outside of the cell...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...from engaging in the very behaviors that radiation targets for destruction, said Dewhirst. "HIF-1 assists cancer cells in dying by a process of self-directed suicide called 'apoptosis,'" said Dewhirst. "If HIF-1 is inhibited prior to radiation, it will make the cell less sensitive to apoptosis and will ther...

IBM Transforms the Art of Scientific Expeditions

...from engaging in the very behaviors that radiation targets for destruction, said Dewhirst. "HIF-1 assists cancer cells in dying by a process of self-directed suicide called 'apoptosis,'" said Dewhirst. "If HIF-1 is inhibited prior to radiation, it will make the cell less sensitive to apoptosis and will ther...

A vaccine to kill tapeworm

... a team at the University of Melbourne, Australia, targets a tapeworm called Taenia solium. The adult form, caught from eating undercooked pork, grows only inside the human intestine, stealing nutrients from the host. This can be debilitating. But far worse is what can happen if people swallow any of the mi...

UIC developing drug for SARS

... proteases -- called 3CLpro and PLpro -- are UIC's targets for drug therapy. "If we can block 3CLpro and probably PLpro, then we can stop the SARS virus from replicating," Johnson said. Under the grant, Andrew Mesecar, associate professor of pharmacy, will study details of the three-dimensional structure o...

Once given 'no respect,' cells' tiny RNAS take driver's seat

...bute to or help prevent cancer -- depends on their targets in the cell," adds Myc specialist Chi Dang, M.D., Ph.D., the Johns Hopkins Family Professor in Oncology Research and a professor of medicine in the McKusick-Nathans Institute and the Johns Hopkins Kimmel Cancer Center. "Slowing E2F1 production would ...

Genetically engineered animals help in scientific research that may benefit children

... molecules to study, or which might be interesting targets for drug development in human chronic kidney disease." Obstructive nephropathy or obstructive uropathy, the kidney disease on which this animal model is based, is frequently found in children and is the first cause of end-stage renal disease (ESRD)....

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