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Tag: "targets" at biology news

Macrophage signaling may affect hormone resistance in prostate tumors

...olving several proteins that may be potential drug targets in the future. Steroid receptors (the proteins that bind and mediate the effects of androgens, estrogens, and progesterone) contain within their structure a novel binding site not previously recognized by researchers, according to the study. This si...

New test to detect rare proteins in blood

...tate the detection of rare markers and not-so-rare targets from much smaller sample volumes, as well as aid in monitoring marker levels at much earlier stages of disease. "The importance of FACTT is that we can still get an accurate description of the number of molecules that cause disease even when other ...

Novel method reveals how menthol discovery could point towards new or improved pain therapies

...In fact, some of these ion channels are considered targets to treat chronic inflammatory and neuropathic pain indications. Understanding how small molecules such as menthol affect the function of these proteins could be crucial in designing future drugs that can either activate or block them." The study wa...

Computer simulation hints at new HIV drug target

...do with a fast-mutating virus like HIV -- new drug targets become vital. "Recognizing these variations in co...d to generate a bunch of conformations as possible targets for drug design." Molecular dynamics simulations have already proved their value in steering drug d...

How sperm crack the whip

...rtility, he said. "Also, these proteins are good targets for contraception," he said. "We know that defects in CatSper1 block fertilization in mice. And since the channels in human sperm are very similar, there's no reason to believe you couldn't develop a male or female birth control pill that would block...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...do with a fast-mutating virus like HIV -- new drug targets become vital. "Recognizing these variations in co...d to generate a bunch of conformations as possible targets for drug design." Molecular dynamics simulations have already proved their value in steering drug d...

New insight into machinery of immune cells' 'tentacles'

...of formation of such "actin filaments" could offer targets for drugs to induce the immune system to work more...ion of the synapse, these new players give us more targets for drugs to treat both immune deficiency and the hyperstimulation of the immune system in autoimmun...

Outsmarting the smartie bug

...ey have put together a complete description of the targets of the vaccine that will help monitor the disease and provide new tools for rapid diagnosis. Pneumococci (formal name Streptococcus pneumoniae) are widespread, causing non-invasive disease, such as ear and sinus infections, and rarer, invasive disea...

Creation of antibiotic in test tube holds promise for better antibiotics

... disease-causing bacteria. Hitting on at least two targets reduces the risk of resistance occurring, van der Donk said. The researchers synthesized nisin simply in a test tube by using a single cyclase enzyme to re-create the process that normally occurs in a strain of the bacterium Lactococcus lactis found...

Scientists make first step towards 'holy grail' of crystallography

...ng the major machinery of living things, are often targets for drugs. To direct the proteins to become crystals, researchers use a substance called a nucleant, which does this by encouraging protein molecules to form a crystal lattice. The research published online in Proceedings of the National Academy o...

Biologists develop genome-wide map of miRNA-mRNA interactions

...s to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). MicroRNAs bind to messenger RNA (mRNA) in a specific section, called 3'UTR, and are known to regulate them. Parts of the predicted map were confirmed through the development of a nove...

Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

... eating behavior could eventually provide new drug targets for treating eating disorders and obesity. The re... further stated, Òthe new work opens up additional targets for obesity research. For example, a drug that decreases Hap1 in the hypothalamus would decrease th...

A large step forward in the fight against African sleeping sickness

...y produced a nanobody (a very small antibody) that targets and binds to the parasite very specifically (Stijlemans et al., 2004). Toya Nath Baral and his VIB colleagues have now succeeded in coupling this nanobody to the abbreviated ApoL-1 variant. This creates a special product that binds immediately to the...

Protein receptor cools passion of 'kiss and run' nerve cells

...'ve identified a specific molecular mechanism that targets the machinery that causes the fusion process and f...ford. "You turn on a G protein, and it immediately targets the mechanism to modify release." On the receiving cell, the post-synaptic side, there is a range o...

New vaccine for condition that kills 500,000 children a year

...of RotaTeq, a vaccine under development. RotaTeq targets five major strains of rotavirus, which account for 90 percent of rotavirus disease. The trial involved infants in the United States, Belgium, Costa Rica, Finland, Germany, Guatemala, Italy, Jamaica, Mexico, Sweden and Taiwan. Infants were randomly a...

Mutation in blood stem cells provides clues to cancer development

...ause if we can pinpoint an inhibitor that directly targets the JAK2 mutant allele, we can fight the disease without inhibiting normal stem cell differentiation. These patients could then still produce normal red blood cells, normal platelets and white blood cells," said Catriona H.M. Jamieson, M.D., Ph.D., ...

Study fishes out new role for prostaglandins

...ancer. The results also may point to new molecular targets for cancer prevention therapies. The findings, published January 1 in the journal Genes and Development, result from a cross-campus collaboration between the labs of Raymond DuBois, M.D., Ph.D., director of the Vanderbilt-Ingram Cancer Center and B....

Chocolate milk could be key to longer, healthier life

... of health benefits, but our research specifically targets mitochondria since they are a cause of age-related decreases in muscle function. "If successful, we could prove that our non-pharmaceutical means to increase muscle quality could mean that a practice as simple as drinking a Milo after exercise may ...

'Prosthetic' retinal cells let blind mice see light

...ion for the restored 'vision' because the approach targets the cellular level. Thus, the expression of microbial-type channelrhodopsins, such as ChR2, in surviving retinal neurons may be another potential strategy for the treatment of complete blindness caused by rod and cone degeneration," they wrote. ...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...ant role in cancer development, and could serve as targets for novel anti-cancer drugs. To discover which miRNAs are expressed in colon cancer, compared to normal colon tissue, researchers at Thomas Jefferson University used a microarray chip containing probes for most of the known miRNAs in human and mous...

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