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Tag: "targeting" at biology news

Can engineered immune cells stop AIDS?

... human cells. Collaborators on his project are targeting hematopoietic stem cells -- the bone marrow cells that form blood cells ?to create B lymphocytes. The researchers want to reprogram these bone marrow cells by adding genes that will instruct the cells to produce rare antibodies such as B12, 4E10, 2G...

Knocking out survival protein could aid leukemia treatment

...l, says Byrd, "Our data indicate that specifically targeting Mcl1 might be effective in the treatment of CLL, particularly when combined with rituximab." ...

Long-lived deep-sea fishes imperiled by technology, overfishing

...cause of food. Technological advances have made targeting these fish easier, the panelists pointed out, because powerful ships can drag huge nets hundreds of feet below the surface. New refrigeration techniques, including "flash freezing," allow ships to range far out into the ocean for days at a time. And ...

Discovery of an HIV inhibitor in human blood points to new drug class

...for development of a new class of HIV-1 inhibitors targeting the highly conserved gp41 fusion protein," the researchers concluded. There are now some 20 different HIV drugs in use, Kirchhoff said. However, the treatments all fall into one of four categories based on their modes of action, and a growing numb...

Trojan horse strategy defeats drug-resistant bacteria

...a co-author on this study. The general approach of targeting stresses already applied by natural defense mechanisms could be a promising new way to treat infections. "We badly need new approaches to fight bacteria," said Singh. "The gallium strategy isn't ready for clinical use yet," he added. "However, w...

New antibacterials being developed to tackle MRSA superbug

... for cell division. FtsZ is not found in humans so targeting a unique protein like this should reduce the likel...is far more selective than those currently in use, targeting only staphylococcal infections," says Dr Lloyd Czaplewski, Director of Research at Prolysis. "Other,...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...t enlists multiple parts of the immune system into targeting p53 in head and neck squamous cell cancer. A phase... allow the immune system to destroy tumor cells by targeting p53. "Instead of creating a vaccine based on mutant p53, which would require a custom vaccine ...

Homing pigeons get their bearings from their beaks

...ning their potential application for accurate drug targeting and even as a data storage device. The main problem, however, lies in their synthetic production. According to Gerta Fleissner and her colleagues, "Even though birds have been producing these particles for millions of years, the main problem for sc...

Chlamydia vaccine a step closer to reality

...and work towards developing a vaccine specifically targeting adolescent women. Professor Peter Timms, from QUT's Institute of Health and Biomedical Innovation (IHBI), said a team of researchers had already identified certain proteins that were able to protect against Chlamydia infection. "We've been test...

A genetic 'gang of 4' drives spread of breast cancer

...d of human breast tumors in mice by simultaneously targeting two of the proteins produced by these genes, using drugs already on the market. The researchers are exploring clinical testing of combination therapy with the drugs—cetuximab (trade name Erbitux) and celecoxib (Celebrex)—to treat breast cancer metast...

Natural antibiotics yield secrets to atom-level imaging technique

...eir membranes. But they're selectively pugnacious, targeting microbes but leaving healthy host cells alone. "They're like smart bombs," Ramamoorthy said. "We'd like to exploit their properties to design super-smart bombs, but before we can do that, we need to understand how these AMP smart bombs interact wi...

Fish extinctions alter critical nutrients in water, study shows

...iology when he conducted the study. "Fishermen are targeting relatively large and abundant species that happen to play a major role in nutrient recycling." The simulations, which relied on data from Rio Las Marias, a Venezeulan river, and Lake Tanganyika, a massive lake bordering Tanzania, Zaire, Zambia and ...

Deconstructing brain wiring, one neuron at a time

... The team's second challenge was to find a way of targeting the viral infection specifically to particular cells, so that the virus could be used to map the connections of cell types of interest or even of single cells. The solution came from a conversation between Callaway and John Young, Ph.D., a Professor ...

Study warns deep-sea mining may pose serious threat to fragile marine ecosystems

...ploration for high-grade gold and copper. They are targeting an area known as the Manus backarc basin off the coast of Papua New Guinea. The active hydrothermal vents in these areas occur where new oceanic crust is formed through undersea volcanic activity. Until the late 1970s, scientists had assumed that lif...

Study shows continued success for new HPV vaccine against virus responsible for cervical cancer

...ers evaluated the efficacy of quadrivalent vaccine targeting HPV types 6, 11, 16, 18 in more than 12,000 women ages 15 to 26 in 13 countries for nearly three years. They found a near 100 percent efficacy rate in prevention of HPV types 16 and 18. "It's the first vaccine designed specifically to prevent c...

Genetic roots of bipolar disorder revealed by first genome-wide study of illness

...he disease by itself, a new study shows. However, targeting the enzyme produced by one of these genes could le...ey respond to a given medication. Identifying and targeting these variations could help scientists develop additional medication options that take these differe...

Targeting sugar on blood vessels may inhibit cancer growth

...cinoma cells in the mice. "We theorized that by targeting the sugar, heparan sulfate, we could affect angiogenesis, which is the formation of new blood vessels," said Fuster. "In cancer, angiogenesis sustains growth as well as metastasis of tumors. An important finding was that, not only could we inhibit ...

Scientists discover rare 'gene-for-gene' interaction that helps bacteria kill their host

..., very few examples of a single gene in a pathogen targeting a single gene in an animal or human host have been identified so far. Photorhabdus is a family of bacteria that in relatively small concentrations can kill insects - between 10-100 cells of it are typically enough ?but most are harmless to humans ...

pHLIP, a novel technology to locate and treat tumors

...the idea is to cause cell death.? In addition to targeting tumors, other disease states that produce inflammation and cause tissue to be acidic are a target for pHLIP. “Acidosis is a physiological marker of many diseases ?and pHLIP feels acidity,?said Reshetnyak. “Therefore, pHLIP could also be used for mon...

Herpes virus hijacks DNA repair process

...kanova, Ph.D., a postdoctoral fellow. "However, by targeting the viral protein responsible for activating the DNA damage response, we may be able to block viral replication. In addition, determining how the DNA repair response helps viral replication may enable us to develop novel strategies to treat infection...

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