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Tag: "targeting" at biology news

Proteins anchor memories in our brain

... "The finding supports the promise of treatments targeting individual body proteins or antigens since we have...e team found was that the immune system was mainly targeting a single eye protein called IRBP despite the fact that several eye-specific proteins were missing in...

Innovative movies show real-time immune-cell activity within tumors

...imensional, time-lapse movies showing immune cells targeting cancer cells in live tumor tissues. In recorded experiments, immune cells called T cells can be seen actively migrating though tissues, making direct contact with tumor cells, and killing them. Insights from this new view of the body's on-board def...

Twenty Years of Malaria Research: Outcomes and Perspectives

...uerrillas from the Democratic Karen Buddhist Army, targeting foreign aid workers in an attempt to force the refugees to return to Burma. During the attack, Professor Nosten and his colleague Rose McGready had been forced to hide in the jungle. Now, Professor Nosten is assisted in his work by Thai nationals f...

Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease

...roviruses known to suppress the immune system. By targeting these amino acids, new drugs could disrupt the ability of these viruses to shut down immune systems and make them vulnerable to the body's natural defenses. "This brilliant study shows that many viruses, including HIV, use a similar mechanism to ...

'Tribbles' protein implicated in common and aggressive form of leukemia

...man cancer adds further support to the notion that targeting the protein degradation machinery will be a useful strategy in treating malignancy." ...

Spelling out cancer on the nanoscale

...d to identify if new cancer drugs are effective at targeting specific oncoproteins." ...

Biologists probe the machinery of cellular protein factories

...ch. Many of the most effective antibiotics work by targeting bacterial ribosomes, and findings by Noller and others have led to the development of novel antibiotics that hold promise for use against germs that have developed resistance to current drugs. Drug-resistant staph infections, for example, are a serio...

'Trojan Horse' agent halts bone metastasis in mice

A novel vascular targeting agent completely prevented the development of bone...osenblum says. "The fact that this form of VEGF targeting works on different cell receptors in blood vessels and in bone cells is a unique finding that could ...

Mayo discovers protein as potential tactic to prevent tumors

...s knowledge represents a potential "bulls eye" for targeting anti-tumor drugs. The findings appear in the current issue of Science. The researchers examined a protein called cyclin-dependent kinase 2 (CDK2), which works as a "quality control inspector." As normal cells divide, they pause in the replication pr...

'Best of both worlds' -- Targeting a single gene could inhibit bone decay and stimulate bone growth

...of Pennsylvania’s School of Medicine have found by targeting the function of a single gene that it is possible ...to the regulation of bone metabolism and show that targeting the function of a single gene could possibly inhibit bone decay while stimulating bone formation. ...

Environmental toxins may cause body's defenses to worsen lung disease

...Lymphocytes, the white blood cells responsible for targeting and fighting off infection in the body, continually survey the epithelial cells lining the lungs to identify and destroy diseased cells. If the lymphocyte recognizes the tissue, Borchers explains, it simply continues its survey for problems. But if t...

To slow AIDS in Russia, treat HIV-positive addicts, Stanford study says

... infections among non-drug users than exclusively targeting the non-drug users. Injection drug users are likely to spread HIV through unprotected sex, so reducing their ability to spread the virus can significantly reduce the spread of HIV to the general population. The researchers also looked at the exp...

Male contraception: One door opens, another closes

...e is both safe and effective in rats. Without this targeting mechanism, only much higher doses are effective--but they are harmful to the body's organs. Dr. Diana Blithe of the U.S. National Institutes of Health, a long-time funder of the Adjudin research, says that "This [new breakthrough] is what they we...

Prion disease treatable if caught early

... in prion-infected mice we have shown here support targeting neuronal [prion protein] directly as a therapeutic approach," wrote Mallucci and colleagues. "Our findings of early reversible neurophysiological and cognitive deficits occurring prior to neuronal loss open new avenues in the prion field," they wr...

Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply

... and they also are snagged as bycatch in fisheries targeting tunas and swordfish in both U.S. and high seas fisheries. As many as 73 million sharks are killed worldwide each year for the finning trade, and the number is escalating rapidly. Ecologists have long predicted that the demise of top predators c...

Killing the messenger RNA -- But which one?

...t our original computer prediction of differential targeting by unedited and edited microRNAs of different sets of genes is likely to be correct," Nishikura says. "And in at least the case of the one gene we investigated, this differential has physiological consequences seen in the elevated uric acid levels." ...

Linheng Li Lab documents the development of cancer stem cells

...ular signature -- providing important insight into targeting these cells," said Robb Krumlauf, Ph.D., Scientific Director. "This is a fascinating new area of cancer research, and Linheng Li and his colleagues will continue to make important contributions." ...

Targeting tumors the natural way

...r cells while sparing healthy ones. The new tumor targeting strategy, presented today (March 25) at the annual national meeting of the American Chemical Society, cleverly harnesses one of the body's natural antibodies and immune responses. "The killing agent we chose is already in us," says UW-Madison chemist...

MicroRNA helps prevent tumors

...pets of RNA that can repress activity of a gene by targeting the gene's messenger RNA (which copies DNA information and starts the process of protein production). The first microRNA was discovered in 1993, in worms. It took seven years for the second one to be found, also in worms, but then the floodgates ...

Anti-herpes treatment reduces HIV levels in women infected with both viruses

... control could become a new form of HIV prevention targeting HIV-infected individuals, as well as providing clinical benefits. Importantly, an HSV vaccine that would either prevent HSV infection or diminish the clinical and sub-clinical manifestations of HSV with a similar efficacy on HIV as HSV suppressive th...

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