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Tag: "targeting" at biology news

Schepens scientists are first to discover angiogenesis switch inside blood vessel cells

...ign drugs that could dismantle existing vessels by targeting this switch inside the vessel cells." Angiogenesis is an important natural process that can be both good and bad for the body. It restores blood flow after injury, prepares a woman's body for pregnancy and increases circulation in a damaged heart. ...

Experimental RNA-based drug kills prostate cancer cells effectively and safely

... Center, uses one type of genetic material, called targeting RNA, to enter cancer cells, and another type, call...d. Previous RNA-based drugs have been nonspecific, targeting all cells in the body and not just cancer cells. As a result, they have caused unwanted side effects...

Combined treatment extends life expectancy for lung cancer patients

...nd the edges of the tumor, it is less effective at targeting the center of the tumor, which tends to be a low-oxygen environment. Thermal ablation, on the other hand, heats the tumor to kill cancerous cells ?reaching the center of the tumor, but not necessarily killing all the cells at the edges. This can le...

Researchers unveil strategy for creating actively-programmed anti-cancer molecules

...g that scientists can use different small molecule targeting agents-called programming agents or adapters-to se...ique approach is the ability of the small molecule targeting agents-called programming agents or adapters-to selectively react in the antibody binding sites with...

Scientists tie several cancers to common 'oncogene engine'

... said Fisher. "In the longer term, the focus is on targeting the real culprit ?and that is the MiT transcription factors or their targets. There is lots of excitement, and I believe that is the way to really nail these tumors." ...

Drug dials down the energy within cells, UM researchers find

...ause it suggests principles that may be useful for targeting other bioenergetic pathways. Now we have some rules that we can apply to be able to modulate the mitochondria in new ways that could be therapeutic." Ultimately, the findings may have applications not only for lupus, arthritis and psoriasis, but als...

miRNA-mediated silencing of mRNAs

...m of the Argonaute-1 protein in the miRNA pathway, targeting transcripts for decay via a deadenylation and decapping reaction. The question of whether miRNAs silence gene expression without affecting mRNA levels has been controversial, and conflicting results have been reported in the literature. Dr. Izaurral...

Increased sensitivity to nerve signals keeps diabetes at bay

... to enhance M3 receptor signaling in beta cells by targeting proteins that modulate M3 receptor function in a specific fashion." Receptors of the same type are also found in other parts of the body, he explained. Therefore, drugs that directly stimulate M3 receptors in general would likely come with problemat...

What controls stickiness of 'smart' chromosomal glue

...at an enzyme called separase snips apart cohesins, targeting a specific subunit of the cohesin complex called Rec8. Also, she said, researchers had found that Rec8 cleavage was promoted by phosphorylation -- the addition of chemical phosphate groups -- of Rec8. Researchers also knew that cohesins release chr...

Liquorice cancer care

...mary results show that they are effective as liver targeting carriers,' says Yuan. Clinical trials are planned for the near future. In addition, glycerrhizic acid is tens of thousands of times cheaper and easier to isolate than the antibodies usually used. Tim Meyer, Consultant Medical Oncologist at the Roya...

Mouse study reveals new clues about virulence of 1918 influenza virus

...5N1 avian influenza, the researchers note. Besides targeting the flu virus itself, Dr. Katze explains, researchers might develop new or improved agents aimed at moderating or halting the human immune system's overactive response to these viruses. ...

Combination therapy shows promising results in patients with advanced lung cancer

...ugs like Tarceva, which block tumor cell growth by targeting the protein EGFR, or epidermal growth factor receptor. Researchers theorized that giving Tarceva with Celebrex, a COX-2 inhibitor, would help battle resistance and prove to be an affective combination against lung cancer. Typically, about 10 percent...

Analysis of breast-cancer gene role offers promising target

...is has significant implications for treatment with targeting agents. Moreover, we stress the value of individual tumor cell analysis for providing information that cannot be obtained by conventional pathological examination." Dr. Debu Tripathy, professor of internal medicine, director of the Komen/UT South...

Ghost protein leaves fresh tracks in the cell

...gues initially assumed that ankyrin was the key to targeting spectrin in all cells. But research in many laboratories had failed to find a cue for targeting that acted through ankyrin, so Dubreuil reworked his hypothesis. "We decided to throw out our assu...

Jumping gene could provide non-viral alternative for gene therapy

...nome, that would be beneficial." He confirmed that targeting integration is possible in a paper he co-authored ...isyadi. "I think it's a short step to take it to a targeting mechanism we can use in humans." Another clear benefit is that transposons are cheaper to produce ...

Killing brain tumors from within: A 'Trojan horse' approach

A new method for targeting malignant brain tumors through inducing the cancerous cells to "commit suicide" has been developed by a team of researchers headed by a Hebrew University of Jerusalem professor of biochemistry. Alexander Levitzki, who is the Wolfson Family Profes...

USC team reveals structure of APOBEC family protein

... billions of different antibodies, each capable of targeting a specific disease-causing agent. Others have been shown to disarm viruses like HIV and hepatitis B. Uncontrolled, of course, the APOBEC proteins could create havoc in a cell. But normally, under the cell's tight regulation, "these are the good gu...

Recurrence of a flu pandemic similar to infamous 1918 flu could kill 62 million

...egies are being thought through that are primarily targeting poor countries." For many decades, published epidemiological literature assumed that mortality rates from the 1918-20 pandemic were distributed fairly equally. A simple population count from that period would lead to the conclusion that about 20 p...

Autoimmune disease triggered if T cells miss a single protein early on

... "The finding supports the promise of treatments targeting individual body proteins or antigens since we have...e team found was that the immune system was mainly targeting a single eye protein called IRBP despite the fact that several eye-specific proteins were missing in...

Quality not quantity important for immune response to HIV

...ed against HIV appear to be ineffective, responses targeting one particular HIV protein can bring about control of the virus." About 40 million people are thought to be living with HIV worldwide. The virus, which causes AIDS, is thought to kill 3 million people each year. Despite being first identified in 1...

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