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Tag: "targeting" at biology news

Botox could help target resistant tumors for treatment

... said Gallez. "Anti-angiogenesis and anti-vascular targeting are methods aimed at destroying the vessels that feed tumors, thereby depriving them of oxygen and nutrients. "In contrast, pro-vascular approaches increase tumor perfusion and oxygenation temporarily." While chemotherapy and radiation treatments...

Chemical guidance of T cells leads to immunologic memory and long-term immunity

...ew vaccine strategies and evaluating whether drugs targeting chemokines might have unanticipated effects on immune function. ...

It's in the genes: Study opens door to new treatment of the blues

...al strategies, such as developing drugs capable of targeting specific proteins in restricted brain areas." ...

Therapeutic prospects beyond Vioxx

...al large pharmaceutical companies to develop drugs targeting this enzyme. Such inhibitors will soon enter human trials. FitzGerald and his colleagues showed that deletion of mPGES-1, in contrast to deletion or inhibition of COX-2, did not predispose the animals to thrombosis or elevate blood pressure. A clue ...

Scientists force viruses to evolve as better delivery vehicles for gene therapy

... of new problems we could address as well, such as targeting the virus to cells it is ordinarily not good at getting into, or speeding its transport through the body," he said. Though Schaffer acknowledges that the technique could be used to help pathogenic viruses evade the human immune system, potentially m...

Salk researchers make fast strides towards understanding how our body controls walking

...med V1 neurons, as being part of the CPG, and gene targeting methods to selectively disable them in order to observe what happens. "It allowed us to peer into this black box that is the central pattern generator," explained Lanuza. V1 neurons are so-called interneurons that relay electrical signals between n...

Faults in newly discovered breast stem cells may lead to tumours

...ion for such a recurrence. Chemotherapy works by targeting cells that are dividing rapidly, which is typical behaviour of cancer cells. But an errant stem-like cell may be more resistant to chemotherapy because it divides more slowly. So while chemotherapy can eliminate the bulk of cancer cells, the tumour f...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...reatments for cancer, such as their specificity in targeting tumor cells and low toxicity. There are currently eight approved anticancer antibody products on the market today and many more are in development. Unfortunately, many marketed treatments lack the desired potency against tumor cells, providing only i...

Molecular force field helps cancer cells defend against attack

...ical molecule, and in the future different ways of targeting either the enzyme itself or targeting the binding between these various proteins will have a major impact on cancer, I believe," Cance sai...

Researchers use mass spectrometry to detect norovirus particles

...etermine the mass--or weight--of the particles. By targeting characteristic particles, or peptides, belonging to the viral coat protein, the virus can be positively identified by matching the results to entries in genetic databases. In the Hopkins study, the researchers analyzed a stool sample treated with vi...

Ancient ants arose 140-168 million years ago

...etermine the mass--or weight--of the particles. By targeting characteristic particles, or peptides, belonging to the viral coat protein, the virus can be positively identified by matching the results to entries in genetic databases. In the Hopkins study, the researchers analyzed a stool sample treated with vi...

Weighting cancer drugs to make them hit tumors harder

...lls multiply more rapidly near the vasculature, so targeting that area is key to chemotherapy's cancer-killing effects," said Mark Dewhirst, DVM, Ph.D., a co-author of the paper who is a radiation biologist and director of the Duke Hyperthermia Program. Dewhirst's team has illuminated numerous mechanisms by wh...

Anti-inflammatory drug's potentially deadly side effect found to be rare

...ther drugs are developed using the same customized targeting techniques. "This drug is a good example of the potential of developing drugs with very specific biological targets in mind," Clifford says. "But this experience also reminds us that there are a lot of hidden icebergs in the ocean we're navigating,...

Researches discover gene critical for protection against septic-shock-induced death

...tudies will determine the therapeutic potential of targeting Nrf2 for treatment of sepsis and other inflammatory diseases that impact public health. ...

New protein target may advance design of HIV and cancer drugs

...op new drugs to fight HIV or cancer by selectively targeting proteins known as zinc fingers. In the May 30 iss...dings may also one day be applied to the selective targeting of zinc fingers involved in the biological processes responsible for the spread of cancer. By applyi...

Study reveals how ADHD drugs work in brain

... pretty important information on the importance of targeting the PFC when treating ADHD," says Berridge, "In particular it tells us that if we want to produce new ADHD drugs, we need to target [neurotransmitter] transmission in the PFC." In the future, Berridge and his colleagues plan to look deeper within th...

Queensland scientists identify molecule that links both sides of the brain

...own that the Ryk receptor molecule facilitates the targeting of individual nerve fibres. "This process is critical for the transmission of sensory information effectively throughout the adult brain." These findings are expected to have long-term implications for development of treatments for several forms ...

Research identifies protein in mice that regulates bone formation

... to increased bone mass. The authors believe that targeting Shn3 and WWP1 for drug discovery is an exciting prospect. Glimcher's lab has forged a collaboration with Brandeis University biochemist Greg Petsko to find compounds that inhibit the two proteins, which could lead to new and better treatments for ost...

Buckyballs boost antibody's chemotherapy payload

... to an antibody without significantly changing its targeting ability. That happens, in large part, because the ...ugs -- strong, covalent bonds -- tend to block the targeting centers on the antibody's surface. If an antibody is modified with too many covalent bonds, the chem...

Case Western Reserve University researchers find protein associated with brain cell death

...f AD are still unknown, the Case researchers began targeting research on the reaction between the plaque and immune cells. In in vitro studies of brain tissue from mice, the researchers found that the microglia had the appropriate immune response that the plaque was harmful, but then the protein Vav was fou...

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