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Tag: "targeting" at biology news

Sensors, a smart dose of medicine for cancer treatment

...that improves clinical outcomes by more accurately targeting tumours and minimising the amount of radiation absorbed by healthy tissue. The result is that patients only receive a high radiation dose where they need it and healthy tissue is preserved. The problem with IMRT so far, however, is that it becomes ...

'Computer-chemistry' yields new insight into a puzzle of cell division

...velopment of numerous cancers. But "drug discovery targeting these phosphatases has been hampered by lack of structural information about how Cdc25s interact with their native protein substrates," the authors wrote in their Biochemistry paper. With the study's results in hand, scientists can now search for po...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...otechnology, aptamers have the potential to act as targeting molecules - directing the delivery of nanoparticle...ers so that the binding properties of aptamers for targeting could be preserved. Additional design criteria consisted of the development of nanoparticles that de...

Researchers use 'trickery' to create immune response against melanoma

...otechnology, aptamers have the potential to act as targeting molecules - directing the delivery of nanoparticle...ers so that the binding properties of aptamers for targeting could be preserved. Additional design criteria consisted of the development of nanoparticles that de...

UCLA scientists discover immune response to HIV differs, even in identical twins

...targets small parts of proteins in the virus. This targeting mechanism itself is genetically determined. ". The...sponse by mutating and changing shape. The twins' targeting of the HIV was remarkably similar 17 years after infection yet their overall TCR characteristics wer...

Preclinical study of a new brain tumor therapy

... devised a strategy to treat tumors by selectively targeting and killing the malignant cells. A new preclinical study, published in the open access journal PLoS Medicine, has applied the approach to combat glioblastoma multiforme (GBM). This is the most aggressive form of brain tumour, growing very quickly bef...

Yale scientists decipher 'wiring pattern' of cell signaling networks

...egg to full grown organism, and for drug discovery targeting human diseases. ...

Source of crucial immune cell in the skin discovered

...ltrate organs and tissues throughout the body. So, targeting the pathway by which these cells are formed could lead to new therapies to help children who now face the possibility of lifelong complications. "It is known that Csf-1 levels are elevated in patients with Langerhans histocytosis," said Dr. Merad. ...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

...f neonatal porcine islets in non-human primates by targeting co-stimulation pathways." The work follows on the heels of similar work published last week by University of Minnesota researchers; those researchers used islets isolated from adult pig pancreases. Neonatal islets were produced in Edmonton using a p...

Pair of studies offer new clues to combat antibiotic resistance

...ty of antibiotics can be significantly extended by targeting the formation of lipopolysaccharides in the outer membrane," says study co-author Timothy C. Meredith, Ph.D., a medicinal chemist who conducted the research as a doctoral student at the University of Michigan with Ron Woodard, Ph.D., a professor of m...

New drug could reduce tissue damage after heart attack

...ngs, published in the journal Nature, suggest that targeting CRP may produce both immediate and long-term clinical benefits following a heart attack. CRP is normally present at trace levels in the blood but its concentration increases sharply in almost all diseases including trauma, infection, strokes and chr...

Light activated anticancer drug targeted to DNA using cisplatin like sub-units

...lex (supramolecule) that exploits cisplatins tumor targeting to deliver a light activated drug. The latest res...ten inefficient process. Now we have added the DNA targeting drug," Brewer said. "We were working on cisplatin analogs before, so we have tied it to light activa...

Driver of anthrax toxicity could lead to late-stage therapy

...ng by anthrax toxin suggest that the immunological targeting of LRP6 may prove useful in protecting against the effects of accumulated toxin during the late stages of anthrax disease when antibacterial methods normally are no longer of therapeutic value," the researchers wrote. ...

Experimental TB drug effective against resistant and latent mycobacterium tuberculosis

...ture outbreaks. Existing drugs are ineffective at targeting latent infection. In laboratory assays our compound is lethal to latently adapted Mycobacterium tuberculosis," says Parrish. The researchers are currently undertaking animal experiments that examine pharmacology and toxicology in preparation for a...

New compound stops brain cell degeneration in Alzheimer's disease

... general because it provides proof of concept that targeting over-production of cytokines by activated glia is ... Alzheimer's disease. The report demonstrates that targeting excessive glial activation can suppress brain inflammation and neuron dysfunction in the hippocampus...

Anthrax inhibitor counteracts toxin, may lead to new therapeutics

.... Antibiotics slow the progression of infection by targeting the bacteria, but do not counter the advanced destructive effects of anthrax toxin in the body. Anthrax toxin is a polyvalent protein complex in that it displays multiple copies of identical binding surfaces on the same structure. The inhibitor desi...

New hybrid virus provides targeted molecular imaging of cancer

...imate goal is to adapt and optimize the AAVP-based targeting prototype for use in patients. ...

'Nano-keys' bind cell receptors and trigger allergic reactions

...es via the membrane interactions, rather than just targeting proteins to block responses. This could lead to designing ligands (molecules that bind to receptors) that trigger a desired response or inhibit an allergic reaction and preventing the release of histamines and other inflammatory mediators. In her pr...

Researchers develop portable 'vein finder' for faster, more accurate injections

...for general blood-flow studies, the vein finder is targeting a very small area of the body. "That means the acoustical beam has to be smaller," says Jim Larsen, a research engineer in EOSL. Another complication is that only a small amount of energy, about 1/10,000 of transmitted waves, scatters off the vein. ...

World first research to speed up cure for ear infections

...id. Dr Ghassemifar said the results of other gene targeting research have indicated that gene therapy (to target wound healing genes) could prevent wound scarring and be potentially applied to clinical scar treatments. Professor Marcus Atlas, Director of LEHI, said that Dr Ghassemifar's work in LEHI's Tissue...

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