targeting 2 3

Tag: "targeting" at biology news

Breast tumors in mice eradicated using cancer vaccine

...r is currently being prepared for a clinical trial targeting a tumor antigen associated with cervical cancer by Advaxis Inc., a cancer vaccine biotech company that has licensed Penn patents on the use of Listeria monocytogenes as a vaccine vector. Paterson is the scientific founder of Advaxis and Chair of the ...

Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation

...tudies will determine the therapeutic potential of targeting Nrf2 for treatment of asthma. “Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice?was written by Tirumalai Rangasamy, Jia Guo, Wayne A. Mitzner, Jessica Roman, Anju Singh, Allison D. Fryer, Masayuki Yamamoto,...

miRNAs and musculature

...hich expression of Dmir-1 has been ablated by gene targeting (Dmir-1 KO). A defect is only revealed when larval growth is initiated by feeding, which triggers paralysis and eventually death of Dmir-1 KO larvae. Analysis of the mutant larvae after feeding reveals disrupted somatic musculature, strongly sugg...

Scientists discover genetic pathway responsible for breast cancer cell growth

...e chance you have to cure the disease." "Research targeting individual molecules associated with pathogenesis of cancer has led to positive clinical results," says Dr. Joseph Ragaz, Director of MUHC Oncology Program. "Evidence-based data on agents such as Gleevac in leukemia, Avastin in colorectal cancer, and...

Tissue regeneration operates differently than expected

...lications for the prospects of stem cell therapies targeting on the regeneration of skeletal or heart musculature. ...

K-State professors discover enzyme responsible for creation of a beetle's hard shell

...lyst for cuticle tanning opens up possibilities of targeting this protein as a way of weakening the beetle's physical defenses against mechanical, chemical and biological injuries, Muthukrishnan said. Better insecticides could be developed as a result of having a more insect-specific target like laccase-2, Kra...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...ponses. But the Hopkins investigators believe that targeting dendritic cells may stop the faulty immune response at a higher "upstream" level since T-cells frequently receive their information from dendritic cells. Testing their idea, Small and his Hopkins colleague Katherine Whartenby used an experimental c...

MicroRNAs have shaped the evolution of the majority of mammalian genes

...matching sequence all that's required for microRNA targeting and gene regulation, and do nonconserved sites als... genomes have good reason to maintain the microRNA targeting sites necessary for turning down these genes at the appropriate place and time." An emerging idea i...

Anthrax stops body from fighting back, study shows

...s to pinpoint the exact protein thelethal toxin is targeting in the neutrophil. There are more than 100proteins that regulate actin-filament formation, and researchers havealready isolated one that may be responsible, Southwick said. The UF findings also could affect research on other diseases. Becauseactin i...

Chernobyl: The true scale of the accident

...ation due to changes in radiation conditions, poor targeting and funding shortages. * Structural elements ...ding to the Report. This recommendation calls for targeting information to specific audiences, including community leaders and health care workers, along with a...

Stem cells' electric abilities might help their safe clinical use

...nto the next phase of a cell cycle." Li hopes the targeting of specific potassium channels will give scientists more understanding and control in engineering healthy cells for transplantation. "We found that blocking potassium channels in ESCs also slowed their growth," says Li. "Our findings may lead to g...

NRL scientists detect 'milky sea' phenomena

...ure satellite systems provides a possible means to targeting these events in the future by properly equipped research vessels. This creates opportunities for new research and insight pertaining to the cause, role, and implications of these poorly understood phenomena, said Dr. Miller. Professor. J. Woodland Ha...

MIT researcher finds neuron growth in adult brain

... in spinal cord injuries, the new finding suggests targeting a different part of the cell: the dendrite. A dendrite, from the Greek word for tree, is a branched projection of a nerve cell that conducts electrical stimulation to the cell body. "We do see relatively large-scale growth" in the dendrites, Nedivi ...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...ncer cells," Dr. Leuschner says. "Without the LHRH targeting moiety, the nanoparticle-drug construct doesn't ki...e LHRH-ironoxide-Hecate combination worked best in targeting and killing breast cancer cells, including metastatic cells. According to Leuschner, the approach ...

A New Era of Hope for the World's Most Neglected Diseases

...king the disparate vertical control programs, each targeting a specific neglected disease, and delivering them in one integrated package. For example, important work is under way to examine the impact of four drugs—albendazole, praziquantel, azithromycin, and ivermectin—in a single delivery mechanism in order ...

Telling axons where to go - and grow

...in ligase Rnf6 polyubiquitinates the kinase LIMK1, targeting it for proteosomal degradation in the growth cones of hippocampal neurons. LIMK1 regulates the dynamics of the actin cytoskeleton primarily via phosphorylation of the actin depolymerization factors ADF/cofilin, with important consequences for cell m...

Switching to new anti-bacterial targets: Riboswitches

...ches, opens a path to the directed design of drugs targeting riboswitches for use as antibiotics. According to the researchers, it is inevitable that bacteria will evolve and that the drugs we use to cure bacterial infections will eventually become ineffective. While it is often possible to alter existing dru...

Cancer support cells may evolve, fuel tumor growth, study shows

... treatment, said Van Dyke. "If the changes you're targeting in the predominant cancer cell are going to affect, say, the supportive tissue, it may be best to develop therapies that hit both types of cell." In their report, the study authors said further work aimed at more fully understanding the signals, the...

Young scientists turn to gel to ease side-effects of cancer treatment

...ique which uses the gel to improve the accuracy of targeting tumour cells. Magnetic Resonance Spectroscopy can be used as an imaging technique allowing the tumour to be identified accurately, because of the differing biological activity in tumour cells compared with healthy cells. A phantom is required to pr...

NIH launches comprehensive effort to explore cancer genomics

...helped to identify several treatments that work by targeting cancer cells with a specific genetic change, such as Gleevec®, a drug for chronic myeloid leukemia and gastrointestinal stromal tumors, and Herceptin®, a drug for one form of breast cancer. These successful developments support further examination of...

1 2 3 4 5 6 7 8 9