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Tag: "targeting" at biology news

NIAID begins clinical trial of West Nile virus vaccine

...rial testing the safety of an experimental vaccine targeting West Nile virus (WNV) opened today at the National Institutes of Health's (NIH) Clinical Center in Bethesda, MD. The vaccine, which will be tested first in 15 healthy adult volunteers, was developed for human clinical studies by researchers at the Na...

Supercomputers to focus brains on AIDS dilemma

...f Theoretical Chemistry at UCSD. "This time, we're targeting HIV integrase, the only HIV enzyme for which no effective drugs have previously been discovered." The other two HIV enzymes are reverse transcriptase, the target for AZT and other drugs, and protease, the target for the protease inhibitors that had p...

Gene therapy cures inherited liver disease in rats

...seases where you are trying to put something back, targeting the liver," he said. He is hesitant to predict when the treatment can be tried in humans. While the viral vector is fairly benign long term, he would like to see one developed that minimizes the body's immune response to it immediately right after i...

Future diabetes drugs may target new protein interaction

...proteins are required for the liver to make sugar, targeting sirtuin1 in a very specific way might help control sugar production in people with diabetes," says Puigserver. "Sirtuin1 interacts with many different proteins, and it's just this one interaction you would want to prevent." But, he says, PGC1 has an...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...proteins are required for the liver to make sugar, targeting sirtuin1 in a very specific way might help control sugar production in people with diabetes," says Puigserver. "Sirtuin1 interacts with many different proteins, and it's just this one interaction you would want to prevent." But, he says, PGC1 has an...

Computational verification of protein-protein interactions by orthologous co-expression

...proteins are required for the liver to make sugar, targeting sirtuin1 in a very specific way might help control sugar production in people with diabetes," says Puigserver. "Sirtuin1 interacts with many different proteins, and it's just this one interaction you would want to prevent." But, he says, PGC1 has an...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...proteins are required for the liver to make sugar, targeting sirtuin1 in a very specific way might help control sugar production in people with diabetes," says Puigserver. "Sirtuin1 interacts with many different proteins, and it's just this one interaction you would want to prevent." But, he says, PGC1 has an...

While on trail of dioxin, scientists pinpoint cancer target of green tea

...s" protein that pharmaceutical experts are already targeting in an effort to develop a new drug to stop the disease, scientists at the University of Rochester Medical Center have found. The research, which buttresses beliefs about the health benefits of green tea with solid scientific evidence, has been cited ...

Second messenger NAADP shows fast, dose-related impact on satiety cycle

...ance. Viagra is the best-known "second messenger" targeting agent One of the problems with many drugs is thei...most successful and recognized secondary messenger targeting drug to reach the market. Cholecystokinin, a first messenger, activates NAADP; so which is 'therape...

Gene silencing technique offers new strategy for treating, curing disease

...reams of water would be to turn off the faucet. By targeting the chromosomal DNA directly, that's just what Dr. Corey and his colleagues accomplished. The researchers targeted chromosomal DNA in two ways. First, they developed a synthetic molecule called a peptide nucleic acid, or PNA, which physically binds ...

Cancer drug slows poxvirus in mice

...rt for the concept of treating viral infections by targeting specific host cell molecules rather than the virus... Kalman says. "The approach of fighting disease by targeting drugs to cellular molecules rather than to disease agents themselves may be applicable to a wide var...

Most common lung cancers may begin in newly discovered cells

... the researchers optimistic about the relevance of targeting BASCs for early tumor detection and chemoprevention in the earliest stage of disease in people. Discovery of the lung stem cells could lead to new therapies for other lung diseases, such as emphysema and cystic fibrosis. "We tend to emphasize cancer...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

...is particularly useful for the rapid generation of targeting vectors, modification of BACs and E. coli chromosomes, as well as viral engineering. Gene Bridges, an EMBL spin-off, is headquartered in Dresden, Germany and maintains a commercial centre is in Heidelberg. For more information, visit: www.genebridges...

Compound from Chinese medicine shows promise in head and neck cancer

...ssive induction of cell death. It's because we are targeting the pathways these cells need to survive," says study author Thomas Carey, Ph.D., co-director of the Head and Neck Oncology Program at the U-M Comprehensive Cancer Center and a professor in the U-M School of Dentistry and the U-M Medical School. To ...

UIC developing drug for SARS

...g. Crucial to the endeavor is Ghosh's strategy of targeting not the sidechains of the proteases, but their bac...utations typically occur in these sidechains. "By targeting the backbone, we create a drug that the virus probably will not be able to evade," Johnson said. Su...

Can two killers make a cure?

...few months. Other teams are trying to find ways of targeting the progenitor cells that give rise to the surface cells. ...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

Silencing Alzheimer's: targeting a key enzyme with gene therapy reversed course of disease in mouse modelsIn mice, that had been genetically engineered to develop Alzheimer's disease, scientists were able to reverse the rodents' memory loss by reducing the amount of an enzyme that i...

Huntington's cure in flies lays groundwork for broader treatment approaches

...gton's disease. Completely reversing a disease by targeting a combination of proteins or genetic pathways, however, reflects the growing need to embrace a broader treatment paradigm in the realm of genetic disorders, says Yin. In working with a disorder such as Fragile X Syndrome, for example, conventional t...

Progress on HIV/AIDS significant but insufficient

...-risk behaviour. The main recommendations included targeting prevention efforts in countries where the epidemic was concentrated among very vulnerable populations, and tightening the bonds between sex, hygiene and procreation programmes. The round table devoted to treatment had reaffirmed the urgent need to e...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

... of the body." The paper is entitled Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. It's published in the June issue of The Journal of Clinical Investigation. In an accompanying editorial entitled Lessons learned from cancer may h...

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