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Tag: "targeting" at biology news

DNA Molecules Used To Assemble Nanoparticles

...rimers, one designed for imaging and the other for targeting cancer cells. Each of the dendrimers also carried a single-stranded, non-coding DNA synthesized by Choi. In a solution of two different kinds of single dendrimers, these dangling lengths of DNA, typically 34-66 bases long, found complementary sequen...

Research advances quest for HIV-1 vaccine

...istics of 4E10 that make it unusually effective at targeting this region. Drs. Burton and Wilson are members of a scientific consortium of laboratories, the International AIDS Vaccine Initiative's Neutralizing Antibody Consortium (IAVI), which is focused on understanding broadly neutralizing antibodies at the...

Novel antiviral technology inhibits RSV infection in mice

...gy and Immunology. "We found that RNA interference targeting avirus's NS1 gene can be administered in the form of a nasal drop orspray. The treatment keeps the host's natural antiviral shield intactand attenuates virus reproduction, providing substantial protectionfrom severe infections over days to weeks."Dr....

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...co-workers at YaleUniversity used molecular probes targeting a gene that is common inhuman and animal coronaviruses to screen hundreds of specimens forcoronavirus genetic material. Ultimately, two specimens were identifiedin which the sequence of chemical building blocks of the gene differedfrom that of known ...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...he discovery of a new aspect of the regulation and targeting of a well-known gene involved with cancer progression will have profound implications as we continue to focus on the causes of tumor development," said Richard L. Edelson, M.D., director of Yale Cancer Center. Other Yale researchers were Steven M. J...

Spider Venom Could Yield Eco-Friendly Insecticides

...d virus would act like a magic insecticide bullet, targeting only cotton bollworms, for example, and leaving be...er (mosquitoes). "One could envision specifically targeting mosquito larvae that carry human diseases such as West Nile or malaria, while leaving other insects ...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...f two. The researchers also said their approach of targeting corrective genes to muscles may have application in treating other muscular dystrophies. Patients with Pompe disease have a defect in a key enzyme that converts glycogen, a stored form of sugar, into glucose, the body's primary energy source. As a r...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...or," Dr. Huang explained. "So recently the idea of targeting cell migration -- metastasis -- has become an alte...s remain unclear. "Obviously, these compounds are targeting some step in the cell-migration process," Dr. Huang said. The activity of a migration-linked protein...

Critical role in programmed cell death identified

... and mammals, opening new avenues for studying and targeting a process vital to development and implicated in cancer and autoimmune diseases. The work, reported in the February 17 issue of Nature, demonstrates the role of mitochondria, the cellular power plant, in prompting worm cells to self destruct. These ...

New SARS Protein Linked To Important Cell Doorway

...iamond MS, Fremont DH. Structure and intracellular targeting of the SARS-Coronavirus Orf7a Accessory Protein. Structure, January 2005, 75-85. Funding from the National Institutes of Health supported this research. ...

NYC's First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention

... prevention programs with a particular emphasis on targeting high-risk populations," said Michael Weinstein, AIDS Healthcare Foundation President. "Clearly men who have sex with men continue to be at risk, as well as African Americans, as President Bush noted last week in his State of the Union address. Rather...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...d that knocking out the Icmt protein using genetic targeting also inhibited Ras, so the scientists decided to search for an effective and specific molecule that could inhibit Icmt function. "We were looking for a small molecule that inhibited this enzyme specifically, without interfering with the normal regul...

Implanted Devices Detect High-Risk Heart Failure Patients

...er. "This approach may play a significant role in targeting a subset of heart failure patients for whom we need to be more aggressive if we don't see early improvement in heart rate variability," Gilliam said. "We would expect that as their heart function improves after implantation, their heart rate variabil...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

...ned. It's the sort of thing that, having worked on targeting viruses for about 15 years, I just couldn't believ...t the same time conserving the viral component for targeting and destroying tumors. Mass production of a retargeted virus was not possible before this specific i...

WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas

...ol activities. A generous outpouring of donations targeting vector-control efforts is facilitating the task. In Banda Aceh alone, some 100,000 insecticide-treated mosquito nets, 20,000 rapid diagnostic tests for malaria and 150,000 treatment courses of artemisinin-based combination therapy - the most effectiv...

Gene Therapy Cures Inherited Liver Disease In Rats

...seases where you are trying to put something back, targeting the liver," he said. He is hesitant to predict when the treatment can be tried in humans. While the viral vector is fairly benign long term, he would like to see one developed that minimizes the body's immune response to it immediately right after i...

Anti cancer virotherapy well tolerated in first human administration, research finds

...earch on CVA21 that showed success in specifically targeting and killing melanoma cells in mice . The virotherapy technique involves the specific targeting and killing of cancer cells through the introduction into the body of the appropriate viral material...

Cerebral navigation: How do nerve fibers know what direction to grow in?

...e development of therapies for spinal cord injury, targeting ephexin and possibly Vav," he speculates, "but much more needs to be known about how ephexin, Vav and other proteins work together to coordinate axon guidance." ...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...t the mRNA. Given that microRNAs have such a short targeting sequence, they may have broad targeting ability, says Han. Significantly, the researchers found that for the AU-rich element degradation to...

Shutting down the HIV assembly line

...thout disrupting AP-3 function in the cell. And by targeting an early step in HIV particle assembly, an inhibitor of this sort would be expected to block viral replication in cells that complete assembly at the multivesicular body as well as those that assemble particles at the cell membrane. ...

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