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Tag: "targeted" at biology news

DNA Molecules Used To Assemble Nanoparticles

...t U-M. Nanoparticle complexes can be specifically targeted to cancer cells and are small enough to enter a di... works. "If you wanted to make a therapeutic that targeted five drugs to five different cells, it would be 25 synthesis steps the traditional way," Baker said....

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...on strategies, including dietary interventions and targeted drugs. ...

Study finds more than one-third of human genome regulated by RNA

...samegroup identified 400 genes in the human genome targeted by microRNAs.(Prior to this study, there were no k...cated, I think we'll find that even more genes are targeted bymicroRNAs," predicts Lewis.In addition, the team discovered some hints about how microRNAs findthe...

NYU researchers simulate molecular biological clock

...samegroup identified 400 genes in the human genome targeted by microRNAs.(Prior to this study, there were no k...cated, I think we'll find that even more genes are targeted bymicroRNAs," predicts Lewis.In addition, the team discovered some hints about how microRNAs findthe...

Molecular machine may lead to new drugs to combat human diseases

... against these diseases by using a strategy called targeted trans-splicing in which introns are manipulated to...e cycle have been crystallized previously, and the targeted trans-splicing technique has been used to repair hemoglobin infected with sickle cell anemia. The ne...

Taking Aim With Nanoparticle PEBBLEs

...target. Instead, they attach to the outside of the targeted cell and shoot reactive oxygen species into it, se...le to wander off and damage healthy cells, so only targeted cells are affected. Including molecules that make PEBBLEs more visible in MRI images provides an add...

UCLA scientists transform HIV into cancer-seeking missile

...Trojan horse ?transporting therapeutic agents to a targeted part of the body, such as the lungs, where tumors often spread," said Chen, a professor of medicine, microbiology, immunology and molecular genetics and a member of the Jonsson Comprehensive Cancer Center at the David Geffen School of Medicine at UCL...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

... these intersectingcircles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others areincreasingly being developed and tested, says Mills, who is discussingthe importance of this pathway at the annual San Antonio Breast CancerSymposium meeting. “At least 20 d...

Genetic Variation Visualization - From EMBL

... these intersectingcircles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others areincreasingly being developed and tested, says Mills, who is discussingthe importance of this pathway at the annual San Antonio Breast CancerSymposium meeting. “At least 20 d...

New Mixing Method for Microchip-Sized Labs

... these intersectingcircles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others areincreasingly being developed and tested, says Mills, who is discussingthe importance of this pathway at the annual San Antonio Breast CancerSymposium meeting. “At least 20 d...

Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications

... nanoparticles involve therapeutic treatments like targeted drug delivery and gene therapy. Nanoparticles of varying size and structure may be created to act as carriers for drugs, genes and proteins. In addition, these porous nanoparticles can be used to host quantum dots and magnetic nanoparticles for bioim...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

The future of cancer treatment - targeted radiotherapy, on a cellular scale. Antibodies coupled to radioactive isotopes specifically seek out, bind to and kill cancerous cells. Provided that you can find something different on the cell surface between normal and cancerous cells; this is not ...

Measuring the impact of post-genomics on Mediterranean populations

...FP6. Ideas for coordinated actions (CAs), specific targeted research projects (Streps), specific support actions (SSAs) are welcomed and, according to the Genomed-Health website, all areas of the FP6 thematic priority one, ‘Life sciences, genomics and biotechnology for health?are open to INCO partners. Biote...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...ficient blood flow. Once the catheter reaches the targeted site inside of the heart, the VEGF-2 is injected into the heart muscle region with inadequate blood supply. The DNA plasmid is then taken up by the middle muscular layer of the heart wall near the injection site. Inside the cell, the DNA encoded VEGF...

Protein offers way to stop microscopic parasites in their tracks

...f interest in this because TgROM5 might someday be targeted with inhibitors," Sibley says. "And by comparison to TgROM5 we can now point to highly similar proteins in malaria and other related protozoa that are also potentially promising targets for inhibitors." ...

Asthma gene clusters identified

...mple, specific therapies for acute asthma could be targeted to genes that are seen in acute, but not stable asthma. Also, in addition to differentiating between an acute and stable asthma attack, the genetic profile may be useful in identifying an imminent asthma attack. Researchers examined 54,675 genes. Th...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

...rch into better prognostic tests, new diagnostics, targeted therapies, predictive therapeutic strategies and p...mplishment puts expO on a projection to exceed its targeted collection and gene expression of 1,900 tumor biosamples over the course of 3 years. Standardizatio...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

... it's meant to go, and it destroys the tumors in a targeted way," says Dr. Russell. Background Biology Natural viruses are cellular parasites. To reproduce more viruses, they need to bind to a partner on their target cell, fuse membranes to enter the target cell and then take over the cellular machinery. Wh...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...two key actors in a signaling pathway that molds a targeted cluster of cells into a hair bud. During the budd...timing of external signals against the response of targeted cells to determine how targeted cells translate signals into changes in cell adhesion and remodeling...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

...esearch laid the groundwork for development of the targeted leukemia therapy Gleevec, is director of the new i...scoveries from the lab to modern medicine. Several targeted therapies were developed based on UCLA research, including Gleevec and the breast cancer drug Hercep...

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