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Brown scientists map structure of DNA-doctoring protein complex
... the body and insert genes into the chromosomes of target cells. This DNA doctoring not only shapes species over time, it also spreads antibiotic resistance and is used by bacteria that spread Lyme disease and by viruses linked to certain forms of cancer. Last year in Nature, scientists working in the Br...Clue found to Epstein-Barr virus' ability to form and sustain tumors
...dicine and Public Health (SMPH) have found a viral target that opens the door for the development of drugs t...dentify specific functions of EBNA-1 that we could target therapeutically," says Bill Sugden, professor of oncology who has studied EBV for more than 30 years...Hopkins scientists link immune response to 'ghost' parasites and severely congested sinuses
... and polyp formation makes the enzyme a legitimate target for drug therapies to block its production and action. "If we can selectively shut down the antiparasite immune response, we could potentially have new treatments for these airway diseases of the lung and nose," says Lane. New therapies are nee...Train your brain to hear your friends at a party
...ams which run like regular computer games, but can target weaknesses in listening skills. By incorporating training exercises much like those performed by the ferrets, they can lead to auditory learning and an improved ability to listen." ...Gene-bender proteins may sway to DNA
...n may prove useful for rational design of drugs to target specific sites on the DNA, whereby one can ultimately develop better gene-based therapies," she said. ...RNA map provides first comprehensive understanding of alternative splicing
...is colleagues first identified Nova in 1993 as the target protein in a neurodegenerative disease termed POMA (paraneoplastic opsoclonus-myoclonus ataxia) that is also associated with several types of cancers. Since then the laboratory has focused on identifying RNA sequences -- and in particular, identifyin...Sensory feedback during speech: The brain attunes to more than just sound
...ing speaking and were thereby able to specifically target vowel or consonant sounds to study whether the production of certain types of sound was especially sensitive to somatosensory cues. The researchers found that over time, the subjects in the experiments learned to compensate for the robotic interferen...Newly identified biomarker detects and regulates spread of brain tumors
...he recurrence of these tumors makes it a promising target for future therapeutic intervention, says Dr. Van ...g the growth of these tumors or as a potential new target for therapy." ...Malaria treatment efficacy compromised in certain HIV-positive patients
...the immune response to malaria, are also the prime target for HIV. Low CD4 cell counts are a characteristic of HIV-induced immune suppression. In this study, Dr. Van geertruyden and colleagues from the Institute of Tropical Medicine in Belgium and the Tropical Disease Research Center in Zambia show that HIV...Novel vaccine shows promise against early-stage breast cancer
...ion Research meeting in Boston looks at a specific target in the fight against breast cancer and evaluates a...overall survival. Developing novel therapies that target these specific genetic variances may be extremely beneficial in preventing breast cancer for many wo...Carnegie Mellon scientists use 'green' approach to transform plastics manufacturing
...use they contain so little copper. However, if the target application -- such as a coating for a biomedical stent -- absolutely requires the removal of residual catalyst, companies will now have much less of it to take out, significantly lowering removal costs, according to the authors. The new ATRP tech...Study illuminates how the plague bacteria causes disease
...entify the pathogen's Achilles heel--an attractive target for antibacterial or anti-virulence compounds." "We were quite excited to see such a critical and unexpected factor in the virulence of Yersinia--a bacteria historically responsible for some of the worst diseases," he added. Although improvements i...Study IDs protein that inhibits HIV from growing in cell cultures
...s over current drugs, as the newer therapies would target the cell in which HIV can replicate and not the virus directly. Therefore, HIV should have more difficulty developing resistance to the effects of this protein," Xiang added. Xiang previously discovered that GBV-C grows in the same type of white b...'Best of both worlds' -- Targeting a single gene could inhibit bone decay and stimulate bone growth
...o to work on the genes up and down stream from our target gene. If we can find a way to get to our target gene with a drug we may be able to help the millions of seniors with osteoporosis." Dr. Choi was ...Embryonic patterning makes the feathers fly
...nistration. But which skin layer was the major target of FGF/MAPK activity, the epithelium or the mesenchyme" The researchers grew skin explants in an environmental chamber that enabled them to continually observe cell movements and track individual cells using fluorescent markers. The results were reco...'Conversation stoppers' fight deadly bacterial infections
...f these enzymes could represent an attractive drug target for a range of human disorders in which disruption of endocannabinoid signaling by cannabinoid receptor antagonists has proven beneficial." ...Nanotechnology propels advances in regenerative medicine research
...f these enzymes could represent an attractive drug target for a range of human disorders in which disruption of endocannabinoid signaling by cannabinoid receptor antagonists has proven beneficial." ...Regulating the nuclear architecture of the cell
...h is a lysine. In the histone code the methylation target is known as H3K9, where K stands for lysine. Methylation of chromatin causes it to condense. Another Su(var) gene, Su(var)2-5, makes a protein called HP1 that binds methylated H3K9 and Su(var)3-9 proteins; the effect is to further close up the ch...Brown seaweed contains promising fat fighter, weight reducer
...f these enzymes could represent an attractive drug target for a range of human disorders in which disruption of endocannabinoid signaling by cannabinoid receptor antagonists has proven beneficial." ......iming drugs at a previously unrecognized molecular target ?has been discovered by University of Utah scienti...c receptors have not been reported previously as a target for any kind of painkilling medication. McIntosh says Vc1.1 is administered by subcutaneous (under t...Other Tagsspeakers 2tips 2protocols 2atom 2
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Other Contentsstomatitisstomatitisvesicularvesicularvirologyvirologyvirologyclassificationclassificationclassificationclassificationclassificationclassificationevolutionevolutionevolutionevolutionevolutionevolutionvirusvirusvirusvirusvirusvirusvirusvirusvirusspectrumspectrumspectrumspectrumspectrumspectrumspectrumspectrumspectrumopticalopticalopticalopticalopticalopticalopticalopticaloptical[0] ASGE Lauds Drop in Colorectal Cancer Deaths[0] Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods[0] University of Alberta researchers develop drug interface to save lives[0] Bad Behavior as a Kid Linked to Early Death in Men[0] Children's National Named to the 2009 Leapfrog Group Best Hospitals List
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