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Tag: "target" at biology news

St. Jude announces breakthrough in eye cancer treatment

...(Nutley, N.J.) for a similar use against a related target called MDM2 in adult cancer cells. The success in knocking out MDMX with nutlin-3 represents the first example of local delivery of a targeted chemotherapy drug for any childhood cancer, Dyer said. Targeted therapy uses a customized drug to disabl...

Gene key to taste bud development identified

...e loss of taste during treatments. These therapies target cells that are dividing, making them effective in killing cancer cells but also causing the unwanted side effect of killing taste buds. When the cancer treatments end, the taste buds gradually return, Hogan said....

Antibiotic inhibits cancer gene activity

...he Oct. 1 issue of Cancer Research. "We chose to target a gene believed to be over-expressed in cancer cel... gives researchers a rapid way to find agents that target oncogenes -- genes believed to cause cancer. He said siomycin A, the first compound found with the m...

Dopamine used to prompt nerve tissue to regrow

... damaged nerves to regrow and reconnect with their target organ. Strange though his idea might have seeme...eration will require the nerve to synapse with the target organ," Wang said. "Since we've written this paper, we've also been able to get the nerves to form e...

Plant studies reveal how, where seeds store iron

...s a promising, and, before now, largely unexplored target for increasing the iron content of seeds. Such nutrient-rich seeds would benefit both human health and agricultural productivity." The findings were published online in the Nov. 2, 2006, ScienceExpress, the advance publication site for the journal...

Signal protein shows promise for blocking tumor promoters in skin cells

...in the Journal of Biological Chemistry, suggests a target for future gene therapy to treat skin, head, neck, colon, and breast cancers. Investigators have known for decades that Src kinase proteins can promote tumor formation. Src kinase activity is elevated in most skin cancers and in common carcinomas, ...

Molecular atlas provides new tool for understanding estrogen-fueled breast cancer

..., "and the estrogen receptor is the most important target for therapy for these tumors. Knowing the complete set of ER binding sites gives us a new resource for understanding the role of estrogen in breast cancer. By identifying genes associated with the ER in breast tumors, it opens up previously unexplore...

Bacteria in small sea life yield new way to make potential cancer drugs

... to modify these compounds and invent new drugs to target human diseases." Sea squirts live with diverse bacteria that synthesize many small molecules. By examining the natural chemical and genetic diversity found in sea squirts and their symbionts, Schmidt and his colleagues from around the country iden...

MRSA toxin acquitted: Study clears suspected key to severe bacterial illness

...y scientists had presumed that CA-MRSA uses PVL to target and kill specific white blood cells known as neutrophils. "The Staphylococcus aureus bacterium is a growing global public health menace because of its rapid spread from hospital settings into communities of healthy people," says NIAID Director Ant...

Plant studies reveal how, where seeds store iron

...s a promising, and, before now, largely unexplored target for increasing the iron content of seeds. Such nutrient-rich seeds would benefit both human health and agricultural productivity." The findings were published online in the Nov. 2, 2006, ScienceExpress, the advance publication site for the journal...

'Super' enzyme may lead way to better tumor vaccines

... that when the enzyme is used in people, the first target will be prostate cancer ?a long-standing interest of his laboratory. However, he said, it could be modified to attack other tumors as well. ...

Fight weeds with plant pathogens

...ich will greatly reduce the growth of, or kill the target weed before economic losses are incurred. Annual applications are required since the pathogen does not generally survive between growing seasons. It is estimated that there are more than 200 plant pathogens that have been or are under evaluation for ...

Einstein researchers demonstrate a novel approach to treating AIDS

...ells that the virus infects. In this study their target was the protein gp41, one of several proteins in the HIV-1 virus that are "displayed" on the surface of HIV-1-infected cells. After obtaining antibodies that would latch specifically onto gp41, the researchers tagged them with two different radioisot...

Gene linked with mental illness shapes brain region, researchers find

... Thus, serotonin has only a brief influence on the target neurons. Drugs that prevent this re-uptake, such as Prozac, are frequently used to treat patients with depression. The serotonin transporter gene has two forms, or variants: short, or SERT-s, and long, SERT-l. A person can have two copies of the ...

Tiny Tampa Bay fish key to evolution of immune system

...we must consider that an organism we are trying to target may have an elaborate defensive system of its own, with features that neutralize what we're trying to do to it," Ostrov said. "For example, if we're trying to create a vaccine against a specific pathogen such as anthrax, smallpox or bird flu, we have...

Tarantula venom and chili peppers target same pain sensor

... and some pain treatments have been developed that target them. The capsaicin receptor acts as a channel o...may have evolved the ability to use such toxins to target heat- and pain-sensing neuron receptors, the scientists conclude. "It is fascinating that plants ...

Peering into the shadow world of RNA

... or miRNAs, non-coding forms of RNA that appear to target and inactivate particular sets of messenger RNAs, ...l/v13/n1/full/nsmb1041.html ). “MicroRNAs often target a specific set of genes,?Nishikura notes. “But when editing occurs, they may target a completely dif...

A valuable fly for research into disease

...tic and pharmacological tests that aim to identify target genes as well as compounds that may lead to future therapies. Moreover, more and more companies that exploit this model system are being established worldwide. In order to highlight the potential of applied science, the organizers of this conference ...

New research identifies gene important for nicotine's effects on the brain

...sation therapies. However, it will not be easy to target the signaling molecules manipulated in this study in human smokers. "They are not just in nerve cells involved in addictive behavior; these signaling molecules are important throughout the brain and body", says Picciotto. "The more we understand ho...

Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia

...ot found in most other bacteria, points to a prime target for development of an effective cure for Chlamydia...ferase they would have a new antibiotic that would target Chlamydia. Chlamydia trachomatis is a bacteria that is responsible for a common STD. If untreated...

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