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Tag: "target" at biology news

Killing the messenger RNA -- But which one?

... in their sequence can redirect these microRNAs to target and silence entirely different sets of genes from ...total of only 19 or 21 ?that define the molecule’s target specificity. This suggested that the change might well redirect these edited microRNAs to silence en...

Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates

...infection can be fatal. By contrast, drugs that target only specific types of bug cause less damage to normal gut bacteria and therefore reduce the likelihood that CD will take hold. In their audit study, Dr Sheldon Stone, of the Academic Department of Geriatrics, Royal Free and University College M...

New dopamine brain target discovered

... different types of dopamine receptors, this novel target may have a significant role in understanding and t...ecific drug triggers. Strikingly, stimulating this target with dopamine or specific drugs triggered a rise in calcium in the brain. As calcium has a profound...

Reactivated gene shrinks tumors

... that the tumor suppressor gene p53 is a promising target for human cancer drugs. "If we can find drugs that restore p53 function in human tumors in which this pathway is blocked, they may be effective cancer treatments," said David Kirsch of MIT's Center for Cancer Research and Harvard Medical School, o...

How T lymphocytes attack

... an infectious or tumour cell, they bind to it and target it with a fatal load of enzymes. When T lymphocytes infiltrate a tumour?/b> Before this work by Alexandre Boissonnas and Luc Fetler, no-one had ever observed at the cellular scale what happens when activated T cells arrive in a solid tumou...

A first glimpse of the influenza replication machine

...plore both structure and function of this key drug target and try to characterise other mutations implicated in bird-to-human transmission." ...

Nanoparticles for delivery of prostate cancer treatment

...borator Zhiwei Hu have developed a way to directly target and destroy the blood vessels of solid tumors, thus destroying the tumors while leaving normal tissue unharmed. The technology uses a synthetic gene encoding an antibody-like molecule that activates an immune response to destroy the tumor blood v...

Minuscule molecules pack a powerful punch

...tical for function of populations of T-cells, is a target for the action of miR-155. The consequences of removal of active miR-155 are altered activation of other genes, failure to mount an effective immune response, susceptibility to autoimmunity and susceptibility to infection. "This dramatic findi...

Smokers quit after damage to brain region

...for survival. As a result, it might be possible to target one without disrupting the other. Hanna Damasio, co-director of the institute and holder of the Dana Dornsife Chair in Neuroscience, also stressed the difference between habitual and instinctive behaviors. "Because the insula is now recognized as...

Immunization rates hit record high in poor countries

...n, inoculated with the right concentrations of the target fungus—will be their factory. By spraying the whey solution into an infected forest, they believe they can get the adelgid-killing fungi to reproduce in large numbers on its own. "The sweet whey only costs 32 cents a pound," says Costa, who gets ...

Fungal factories may save hemlock forests

...n, inoculated with the right concentrations of the target fungus—will be their factory. By spraying the whey solution into an infected forest, they believe they can get the adelgid-killing fungi to reproduce in large numbers on its own. "The sweet whey only costs 32 cents a pound," says Costa, who gets ...

Unicellular microRNA discovery

...RNAs, in so far as they can direct the cleavage of target mRNAs in vitro and in vivo. Furthermore, they found that miRNA expression patterns changed during gamete differentiation, suggesting a possible role in regulating sexual reproduction. The discovery of miRNAs in a unicellular organism has evolution...

Reversing cancer cells to normal cells

...rd a normal skin cell provide a previously unknown target for regulating tumor progression and metastasis. Dr. Hendrix’s distinguished lecture is part of a session titled the cell microenvironment in development and cancer....

Major link in brain-obesity puzzle found

...he finding gives scientists an important system to target in future research and the development of anti-obesity medications. In the February issue of the Journal of Clinical Investigation, U-M researcher Liangyou Rui, Ph.D. and his team report their findings on a protein called SH2B1, and specifically o...

New UD technology removes viruses from drinking water

... hygiene. In the United States, viruses are the target pathogenic microorganisms in the new Ground Water Rule under the Environmental Protection Agency's Safe Drinking Water Act, which took effect on Jan. 8. "What is unique about our technology is its ability to remove viruses--the smallest of the pat...

A sweet step toward new cancer therapies

...nostic tools or therapeutic agents to specifically target them," Hakansson said. ...

Faster, low cost sequencing technologies needed to drive era of personalized medicine

...l Institutes of Health (NIH), has set an ambitious target of $1,000 or less - a cost 10,000 times lower than current technology - to make genome sequencing a routine diagnostic tool in medical care. The reduced cost may allow doctors to tailor medical treatments to an individual's genetic profile for diag...

Common cold virus may kill breast cancer cells

...lls. "In theory, the virus is able to selectively target and destroy many different types of cancer cells, including breast cancers, whilst leaving normal cells unaffected," she said. Debilitating symptoms associated with conventional treatments (such as nausea, vomiting and hair loss) could also be avoi...

Dig deeper to find Martian life

...es is slim. Scientists will need to dig deeper and target very specific, hard-to-reach areas such as recent craters or areas where water has recently surfaced. Dr Andrew Coates, UCL Department of Space & Climate Physics, said: "This study is trying to understand the radiation environment on Mars and...

Stress hormones may play new role in speeding up cancer growth

...rowth in new tumors so that they can grow." The target adrenergic receptors for these hormones are well-known to clinicians dealing with high-blood-pressure patients. Typically, such patients are given a class of drugs known as beta-blockers which lead to a lowering of blood pressure levels. Glaser an...

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