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Tag: "target" at biology news

Protein found to shield pancreatic cancer cells from self-destruction

...a says. "We are developing TG2 as a pharmaceutical target and are now working with a mouse model to that end...o known to regulate autophagy called the mammalian target of rapamycin. "Targeting TG2, or its activating protein PKC, or both, presents a novel and potent...

Susceptibility to Crohn's disease -- an important new clue

...ing the way towards personalized medicine and drug target identification. ...

Scientists uncover new target in cancer mutation puzzle

...gene. Someday Rho may prove to be an attractive target for therapy because it is highly active only in ma...nderstand more about the role of Rho proteins as a target of cooperating cancer gene mutations in tumors with p53 mutations, we will look for other molecules ...

Long-lived deep-sea fishes imperiled by technology, overfishing

...bal positioning systems (GPS) and fish finders can target schools of fish or seamounts with ease. "One reason that many of these fish species were fished sustainably in the past is that we couldn't fish all of the places all of the time," Heppell said. "That isn't necessarily true anymore." Heppell is...

Knocking out survival protein could aid leukemia treatment

...findings demonstrate that Mcl1 may be an effective target for drugs directed against CLL and ALL," says principal investigator John C. Byrd, professor of internal medicine and director of the hematologic malignancies program at Ohio State's James Cancer Hospital and Solove Research Institute. "These res...

Scientists identify a gene that may suppress colorectal cancer

...uced by about 90%. “This gene may give us a novel target to aid in the diagnosis, prevention, and/or treatment of cancer,?says Dr. Arthur Buchberg, one of the co-senior authors on the report. The gene is called Atp5a1 , and encodes an essential component of the cell’s energy-production machinery. Mice...

Living with water scarcity -- world must act now

...ential in the fight against poverty. Actions that target livelihood gains of smallholder farmers by securing water access through water rights and investments in water storage and delivery infrastructure are essential ingredients. The value obtained per drop of water can be improved by pro-poor water tech...

Can engineered immune cells stop AIDS?

...problem seems to be making sure lentiviral vectors target only hematopoietic stem cells, and not other types...h biologists, Wang is experimenting with CD20 as a target antigen for human B cells. His strategy, published in the August 1, 2006 issue of Proceedings of th...

Experimental vaccine given during pregnancy reduces stillbirths from common virus

...hey produced antibodies to the virus—proteins that target foreign molecules for later destruction by the immune system. The vaccinated guinea pigs also showed an activity against the virus by their T cells, immune cells critical to the response against disease-causing organisms. Dr. Schleiss said the cu...

Inhibiting blood to save the brain

...ategies to develop therapies to fight MS primarily target T cells," said Katerina Akassoglou, Ph.D., assistant professor in UCSD's Department of Pharmacology, whose study was published in the March 19 issue of Journal of Experimental Medicine. "Blood proteins have been neglected as a therapeutic target, b...

Microfluidic chip helps solve cellular mating puzzle

...edications with fewer side effects and others that target mutations associated with cancer. ...

Anti-herpes treatment reduces HIV levels in women infected with both viruses

...haviour change. Therefore, innovative methods that target the biological susceptibility of individuals to acquire or transmit HIV are also required. A number of options to prevent HIV transmission are currently being investigated, including the role of vaginal microbicides, pre-exposure HIV prophylaxis, mal...

Moonlighting enzyme linked to neurodegenerative disease

...ent associated with DLD deficiency and represent a target for therapies of this condition," the authors writ...n the regulation of frataxin and could represent a target therapy for Friedreich's ataxia," says Dr. Isaya. The severity of Friedreich's ataxia is proporti...

MicroRNA helps prevent tumors

...roRNAs, and the ability of individual microRNAs to target hundreds of genes, researchers have struggled to s...al impact of a particular microRNA on a particular target in mammals (although such connections have been shown in plants, worms and flies). Several groups ha...

Scripps Research study reveals new activation mechanism for pain sensing channel

...by several pharmaceutical companies as a potential target for chronic pain, Patapoutian noted. ...

Targeting tumors the natural way

...onal antibody, that is powerfully attracted to the target receptor and holds fast to any cell displaying it....nding agents that attach only weakly to any single target receptor, and thus stick to cells only when several receptors are displayed together. These weak "mu...

MicroRNAs can be tumor suppressors

...umors). This paper establishes that HMGA2 is a target of let-7, and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells. ...

2,000 influenza virus genomes now completed and publicly accessible

...ally. Seasonal flu shots are updated every year to target the latest strains in circulation. Developing such vaccines is challenging, however, because the influenza virus is prone to high mutation rates when it replicates, and these mutations can alter the virus enough that vaccines against one strain may n...

Research to spotlight carbon monoxide benefits

...ade to give benign non-toxic products which do not target immune response." Dr Lynam added: "We don't want to administer carbon monoxide in its normal toxic gaseous form; rather we want to develop molecules that will release it in a sort of slow trickle feed. We aim to make tuneable compounds which allow...

New culture method for hepatitis C virus uses primary hepatocytes and patient serum

...ication in nontransformed hepatocytes, the natural target of the virus. By allowing infection by patient serum containing a wide array of virus strains, this system may allow better understanding of the differences between different strains, further improving treatment strategies. ...

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