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Tag: "target" at biology news

Protein discovery targets antibiotic-resistant bacteria

...chemistry). “It turns out to be a potentially good target in a wide range of bacteria that cause infectious ... being developed at Queen’s could potentially be a target for treating typhoid as well. The underlying goal is to control, if not clear, the infection. “It...

UCSF brain tumor vaccine trial shows promising results

... designed to reprogram the body’s immune system to target only cancer cells bearing this fingerprint. The vaccine is intended to leave healthy tissue unaffected and limit the debilitating side effects typically associated with traditional cancer treatments such as chemotherapy and radiation therapy. Vitespe...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...cers. Wild type sequence p53 as a vaccination target for squamous cell carcinoma of the head and neck: ...tom vaccine for every patient, our strategy is to target parts of the unaltered p53 protein that can best activate the immune system," said Theresa Whiteside...

Failure to meet United Nations sanitation target could affect millions of the world's poorest

...ns "to meet the needs of the world's poorest." The target is based on data from 1990, when 20 percent of the...ieve only part of the Target 10 objective. "The target of reducing to one-half the proportion of people who do not have access to improved water supplies w...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

... vulnerability on the virus that we may be able to target with vaccines. This is certainly one of the best leads to come along in recent years." ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...ailor existing therapies to individuals and how to target experimental agents." Gray and his colleagues h...icular recipient, Mousses said. To search for target genes that regulate Tykerb response, Mousses and his colleagues performed a genome-scale scan of two...

Biologists prove critical step in membrane fusion

...mbrane-bound drugs can be induced to hemifuse with target cells ?rather than fully fuse ?there is the potential to control the timing of drug delivery. ...

Racing neurons control whether we stop or go

...ments, the monkeys were taught to look at a visual target unless a stop signal came on, in which case they w...said. "Each trial began with the illumination of a target in the periphery that the subject was supposed to look at. This is when the ‘go?unit was activated....

OHSU lab finds meth receptor that could lead to therapy

...y found. The signaling system could soon become a target for therapies aiming to reverse meth’s adverse hea... and Pharmacology, scientists demonstrated the new target of meth, and its close relative amphetamine, is a G protein-coupled receptor known as trace amine-as...

Trojan horse strategy defeats drug-resistant bacteria

...bacteria might be vulnerable to interventions that target iron," explained Yukihiro Kaneko, senior fellow in microbiology at the UW and the study's lead author. To accomplish this, the researchers used gallium, a metal very similar to iron. "Gallium acts as a Trojan horse to iron-seeking bacteria," s...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

...e the lung. The finding suggests a new therapeutic target for treating lung infections in some cystic fibrosis (CF) patients. Lung infection, facilitated by CF mutations, is the main cause of death in CF patients. This bacterial component to CF now helps explain why the severity of CF symptoms did not ma...

Notorious cancer gene may work by destroying messenger

... and this enables it to join with, or bind to, its target mRNA. Peng then used monoclonal antibodies to isolate PMR1 and the enzyme while the two were bound together, capturing both. After separating the two, the investigators identified the enzyme as Src, which is a member of a large family of molecule...

Scientists map key landmarks in human genome

...es. "We wanted to understand how MITF regulates target genes, and specifically where in promoter regions of those genes does MITF bind," Fisher said. "In the process of this work, we asked whether MITF is binding between nucleosomes or on top of nucleosomes, and that led us to devise a method to ask wher...

Scientists create dual-modality microbeads to improve identification of disease biomarkers

... easier and faster method to detect these types of target molecules in liquid samples using highly porous, m...lor beads allows the researchers to detect several target molecules at the same time in the same liquid sample. "We use the quantum dots to create a set of...

Chemical switch triggers critical cell activities

...which then helps E2 hand NEDD8 off to the ultimate target molecule at the end of the race. In the cell, this NEDD8 relay race triggers a number of biochemical reactions, one of which takes the brakes off cell division, allowing cells to multiply, according to the researchers. These thioester bonds are chemi...

Custom-made cancer cell attacks

...tive fuels by 2017, roughly five times the current target set by Congress of 7.5 billion gallons by 2012. A...n than other grasses, and reaching the president's target of 35 billion gallons of biofuels annually would require putting far fewer acres of land into Miscan...

Cellulosic ethanol: Fuel of the future?

...tive fuels by 2017, roughly five times the current target set by Congress of 7.5 billion gallons by 2012. A...n than other grasses, and reaching the president's target of 35 billion gallons of biofuels annually would require putting far fewer acres of land into Miscan...

Researchers discover genetic cause for word-finding disease

...e. What makes it so specific? How does the disease target the language areas?" "This finding will help us explore not just what causes the disease but the uniquely identifying features of human language. That's a pretty big question," added Mesulam. MRI imaging of the brains of people with PPA shows ...

Stopping plants from getting sick

... the right kind of fungicide might be developed to target that ability and block infection. "These pathogens provide us with the best of both worlds in terms of research ?we can study them in the field, but we can also bring them to the laboratory and isolate the genes that allow them to infect the plant...

Discovery of an HIV inhibitor in human blood points to new drug class

... to the researchers. "The findings reveal a new target for inhibiting HIV that remains fully active against viral strains that are resistant to other drugs," said study author Frank Kirchhoff of the University of Ulm in Germany. "That's a big advantage." Kirchhoff's group also provided evidence that H...

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