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Tag: "target" at biology news

Genes set scene for metastasis

...e researchers conclude that drug combinations that target one or more of the proteins encoded by these genes may prove useful for treating metastatic breast cancer. ...

Scientists find hormone activity explains adolescent mood swings

...vent. Specifically, the GABA-A receptor is the target for steroids, such as THP (or allopregnanolone), which reduce anxiety. GABA-A receptors calm activity in the brain. As such, they are the targets for most sedative, tranquilizing drugs. One sub-type, GABA-A receptors containing the delta subunit,...

A genetic 'gang of 4' drives spread of breast cancer

...might also be used for some related purpose in the target organ, the lung." To test this idea, the researc...A molecules are tailored to suppress expression of target genes. "We found that depriving aggressive metastatic tumor cells of these genes decreased both th...

Bacteria control how infectious they become, study finds

...said. It's only when RfaH finds the appropriate target sequence on a bacterium's DNA that this small portion of the protein is unmasked and can then turn on a select group of genes. These genes let disease-causing bacteria infect their host while at the same time protecting the bacteria from the host's i...

Antifungal drug kills TB bug

... knowledge that existing anti-fungal drugs already target P450s as a way to treat, for example, systemic and more superficial infections caused by fungi such as Candida albicans (the causative agent of thrush). "The class of drugs called azoles are able to kill off fungal infections by blocking the actio...

Secret of worm's poison pill box protein could produce new natural insecticide

...d body of the insect. The toxin not only kills the target insect but prevents other predators from eating th...BBMV). The XptA1 protein seemed to specifically target the BBMV of caterpillars Pieris Brassicae ?(The cabbage white butterfly caterpillar which are pests ...

Microbes start immune response by sneaking inside cells

...ccines, as well as drugs that could more precisely target the body’s inflammatory response in rheumatoid arthritis and some other autoimmune diseases. “In our study, the presence of bacterial microbes inside the cell is what triggers the immune response. That creates a new perspective for developing new ...

Trusting your instincts leads you to the right answer

...y were unaware that their gazes had shifted to the target just before the image was hidden and their answers...s and examines whether the candidate really is the target or not. If the target is not distinctive enough in the 'eyes' of the conscious, failure of identific...

Rapid, Low-Cost DNA Testing

...say, which rapidly determines whether specific DNA target sequences are present in an analyte. In simple terms, the analyte contains the DNA target sequences as well as other DNA sequences, and the assay filters out only the targets. Professor Roth...

Mechanisms involved with tumor relapse identified

...vant, with a tumor antigen HER-2/neu, as a protein target expressed in breast tumors. Adjuvants are agents that are able to modify another agent ?basically working as a chemical catalyst. ...

Why doesn't the immune system attack the small intestine?

...remarkable that intestinal tissue is so rarely the target of an immune attack. Our findings demonstrate that the immune system has features that remain to be discovered." ...

Blame the brain for high blood pressure

...rain, so that we know what drug to use, and how to target them. JAM-1 could provide us with new clues as to how to deal with this disease. ? Professor Jeremy Pearson, Associate Medical Director of the British Heart Foundation, commented: “This exciting study is important because it suggests there are unex...

Turning green gunk to gold, anti-cancer gold

...cal trials. "This issue represented an exciting target that offered not only an interesting scientific problem, but the potential to do something of practical importance in creating a promising anti-cancer drug," he said. ...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

...onse, suggesting that RPL8 may be an ideal vaccine target for patients that display this antigen in tumors. ... of the cloned melanoma antigens that are known to target helper T cells are mutated and individual-specific, meaning that they may work in treating a single ...

MicroRNAs as tumor suppressors

...origenesis. This paper establishes that HMGA2 is a target of let-7, and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells....

New cell type identified in cancer development

... precancerous cells that may one day be a valuable target for new drugs and treatments. "To cure cancer, we have to eliminate all potential malignant cells ?not just the ones within easy reach." ...

Destructive enzyme shows a benevolent side

...zyme PMR1 is there in the stress granules with its target mRNA." Schoenberg and his colleagues will next study the other proteins within stress granules to try to learn how PMR1-mRNA complex is preserved. ...

Scientists sequence genome of parasite responsible for common sexually transmitted infection

...inalis parasite that causes trichomoniasis, we can target our efforts to developing the most effective medic...arasite's hydrogenosome--its energy source and the target of the two drugs approved to treat trichomoniasis--and identified possible ways the parasite may bec...

Elucidation of the genome for diabetics with DNA chips

...sulin-secreting cells (ZnT8), which is a potential target for treatment. This study of the French population was carried out as a French-British-Canadian collaboration between the teams directed by Philippe Froguel (CNRS, University of Lille 2, Pasteur Institute, Imperial College London) and Rob Sladek (McG...

Scientists find potential 'off-switch' for HIV virus

...en," Weinberger said. "If we can create drugs that target these enzymes, perhaps we can get SirT1 and relate... Weinberger said that drugs already exist that target other cellular enzymes, so there is reason to hope the approach will work. "There is precedent f...

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