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Tag: "target" at biology news

30+ AIDS vaccine clinical trials in 24 countries, research occurring on every continent

...ven more novel vectors, as well as approaches that target neutralizing antibodies in the next few years," said CEO and President of IAVI, Dr. Seth Berkley. IAVI and its collaborators are currently conducting four ongoing trials in India, Kenya, Rwanda, Uganda, South Africa and the United States. In 2006...

Study suggests some drug resistance to influenza B medications

...pies that use alternative mechanisms of action and target different points in the viral life cycle. The emergence of drug-resistant influenza B should draw attention to the importance of continual monitoring of strains over time and to the need for frequent rethinking of policies for use of antiviral drugs....

Gut research yields new anti-cancer approach

...ith new drug delivery technologies that help drugs target only cancer cells, we are very excited about the potential of this line of work." ...

Using nanomagnets to enhance medical imaging

... contrast could be turned on only when bonded to a target molecule or cell. Toxicity is not believed to be an issue, because iron is naturally found in the body and other studies have found that these materials are non-toxic at the concentrations used in MRI. NIST works with Florida State University to m...

Beyond the DNA: Chemical signatures reveal genetic switches in the genome

... regions - some of which are very distant from the target gene - to which transcription-activating cofactors bind. According to LICR's Dr. Bing Ren, the study's senior author and assistant professor at UCSD's Department of Cellular and Molecular Medicine, the method is widely applicable and its unbiased...

In obesity, brain becomes 'unaware' of fat

...d. The results also “strongly validate?SOCS-3 as a target for antiobesity drug development. ...

Study shows isolation of stem cells may lead to a treatment for hearing loss

...eaf before reaching adulthood. In most cases, the target is the highly specialized hair cells. Docked inside the spiral duct of the human cochlea are ~15,000 hair cells, which are highly specialized neuroepithelial cells that enable us to hear a violin or a whisper. These hair cells differ in length by m...

Mutation improves memory, may lead to memory-enhancing pill

...by Cell Press. These findings point to a potential target for the development of a drug to treat memory loss, according to the researchers. The researchers studied a gene that normally increases levels of a natural memory-blocking protein. Animals that carry a defective version of this gene showed improved...

Navigable nanotransport

... transport pharmaceutical agents to their specific target organs or cell types, you need a good carrier: nan...les with surface elements that can "recognize" the target in question could do the trick. To date, all methods for the production of such tiny capsules requi...

Major gene study uncovers secrets of leukemia

... to make effective antibodies against the specific target they are supposed to attack. However, if these defective B lymphocytes do not differentiate because of the mutations, the body will not recognize them as defective immune cells and destroy them. Instead, these undifferentiated cells continue to multi...

Researchers learn what sparks plant growth

...ls of the shoot. "Our study says that the major target tissue in the shoot for steroid hormones is the epidermis. Our results also show that these hormones act locally. As similar studies are done for other plant hormones and in other organs, such as the root, we will know the major sites of action of ea...

Scripps research study shows humans and plants share common regulatory pathway

...uggests that one possible role of SGT1 could be to target resistance-regulating proteins for degradation," he added. "In this hypothesis, the target protein would be a negative regulator of immune responses." Future studies, Ulevitch said, will f...

Researchers identify ovarian cancer biomarkers

... could be a new avenue to develop drugs that would target the blood vessels and strangle the tumor. Biomarkers are also seen in other cancer types as a potential screening tool. A new way of detecting ovarian cancer could make a significant dent in this disease, where 70 percent of patients are diagnosed...

Veterinary scientists explore poultry virus as cancer killer

... disease virus through a reverse genetic system to target prostate cancer specifically. Reverse genetics is the process of generating a recombinant virus from cloned complimentary DNA (cDNA) copy of a viral genome, explains Subbiah. Through the reverse genetics system, recombinant viruses can be designe...

New player in commitment to life as a fat cell

...ur results identify XOR as a potential therapeutic target for metabolic abnormalities beyond hyperuricemia," the researchers said. "To our knowledge, there have not been studies designed to explore the effects of XOR inhibitors on body weight, and in light of our findings, such studies may be warranted,"...

RNA splicing factor implicated in ovarian tumor cell growth

...s overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago. Researchers in the UIC College of Pharmacy found that interfering with the production of a splicing factor can inhibit the gr...

Tracking sperm whales and jumbo squid

...consumers of squid, including jumbo squid, now the target of a thriving commercial fishery in Baja Californi...e surface." A stressed-out squid may be an easy target for hungry sperm whales waiting below, according to Gilly. "We propose that jumbo squid are more sus...

Bacterial walls come tumbling down

The first detailed images of an elusive drug target on the outer wall of bacteria may provide scientis...s for use in humans. "This enzyme is an awesome target for antibiotics," said Strynadka. "We have a totally new understanding of how the enzyme works and h...

Soft-cell approach cuts animal tests

...h as lung, skin and liver can be used to represent target organs that are more likely to be significantly exposed or affected by air pollutants. As the respiratory system is both a site of toxicity for pulmonary toxicants, and a pathway for inhaled chemicals to reach other organs, relevant airway cells and ...

Columbia scientists determine 3-dimensional structure of cell's 'fuel gauge'

...ep forward for the rational design of new drugs to target diabetes and obesity," said Lawrence Shapiro, Ph.D...rgy. AMPK provides an especially promising drug target for people with type 2 diabetes. These patients are insulin-resistant, meaning that their cells are...

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