New research shows sharks use their noses and bodies to locate smells
...the odor alone (the odor-oozing nozzle). Plume and target preference and search time were not significantly affected by light condition. In the light, lesioning the lateral line increased search time, but did not affect success rate or plume preference. However, lesioned animals no longer discriminated ...Detecting cold, feeling pain: Study reveals why menthol feels fresh
...or – known as menthol receptor TRPM8 -- provides a target for studying acute and chronic pain, as can result...e injury, the researchers say, and a potential new target for treating pain. "By understanding how sensory receptors work, how thresholds for temperature a...Salk scientists hammer out a pathway that promotes muscle cell survival in mice
...now firmly in place, expression of muscle-specific target genes was also reduced. Conversely, when the researchers boosted SIK1 levels or inhibited HDAC activity with a drug, muscle cell health was restored in mice genetically engineered to lack CREB and suffering from muscle weakness as a result. "...'Personality-gene' makes songbirds curious
...ard to control experimentally. Birds are an easier target for research and indeed, they also have different personalities. An international team of researchers have now found evidence for the existence of a "curiosity-gene" in a songbird, the great tit (Parus major). The gene (Drd4) carries the building i...'Insulator' helps silence genes in dormant herpes virus
...ay help finding ways to develop therapies that can target the virus and not the host." ...pHLIP, a novel technology to locate and treat tumors
...ity of Rhode Island have demonstrated a new way to target and potentially treat tumors using a short piece o...e inflammation and cause tissue to be acidic are a target for pHLIP. “Acidosis is a physiological marker of many diseases ?and pHLIP feels acidity,?said Resh...Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
...ay, as well as many hormone and neurotransmitters, target a specific family of cell surface receptors known as G-protein coupled receptors. The researchers believe that the presence or absence of nitric oxide or SNOs determines whether these receptors continue to function properly. This action is controlled...Alien plants attack using 'resource conservation' as weapon, researchers say
... what the characteristics of the invasives are and target your strategy to those characteristics," he said. Funk pointed to recent experiments that tried to eliminate invaders by deliberately reducing available resources-for example, by mixing sugar into the soil to lock up nutrients or by blocking sunli...Targeting sugar on blood vessels may inhibit cancer growth
...ng cancers. "If novel drugs can be developed to target tumor heparan sulfate, we might be able to make a leap in cancer-fighting therapies, because several molecules critical to tumor endothelial growth also bind to heparan sulfate," Fuster said. "Altering this binding would allow for suppression of a b...Genetic roots of bipolar disorder revealed by first genome-wide study of illness
...a very few years ago. We now have a new molecular target scientists can investigate in their search for bet...e better prevented or treated. "Treatments that target just a few of these genes or the proteins they make could yield substantial benefits for patients. ...Molecule that destroys bone also protects it, new research shows
...nflammation in autoimmune diseases. Therapies that target IL-17 or its cellular receptor currently are being...ut also because the consequences of therapies that target these cytokines need to be understood." ...Warts vaccine -- 1 of many in pipeline
...illomaviruses responsible for genital warts was on target at the halfway mark, according to Australian of the Year 2006 Professor Ian Frazer and trial manager, sexual health specialist Dr David Jardine More than 200 patients in China and Australia have taken part in the trial so far run from the Princess ...Chemical maps hint at drug's effects on schizophrenia
..."Now we can begin to develop better medicines that target the specific metabolites important for the disease but not those that could lead to detrimental side effects." Although some lipids are known to have detrimental effects on human health -- such as high levels of cholesterol that lead to heart dise...New study examines 'brain's own marijuana'
...nxiety. An alternative strategy may be to directly target the ‘brain’s own marijuana.’? The success of such a strategy requires a better understanding of how endocannabinoid moderates stress-related behaviors and how stress and stress hormones activate the endocannabinoid system. Haj-Dahmane and his co-...The quest for an effective HIV vaccine presents new possibilities, challenges
...the virus because of its ability to integrate into target cells and evade clearance by the immune system. The interaction between HIV and the immune system is complex, and how different HIV-specific immune responses help to control infection is only partially understood. "The development of an HIV vaccin...Newly identified mechanism for silencing genes points to possible anti-cancer strategies
...nces against particular messenger RNA sequences to target them for destruction," explains Ramin Shiekhattar, Ph.D., a professor"in the Gene Expression and Regulation Program and the Molecular and Cellular Oncogenesis Program at Wistar and senior author on the new study. "That’s one way we know that microRNA...Biodegradable microspheres deliver time release vaccines, stimulate different immune response
... (CMI). CMI allows the immune system to identify, target and kill cells that have already become infected, something antibodies can not do. The determine the cause of this effect, Wilson-Welder and her colleagues next incubated human dendritic cells in the presence of polyanhydride microspheres (without...UCLA study uncovers clues for why Graves' disease attacks the eyes
...toimmune disorder damages the body and offer a new target for treating the disfiguring disease. Earlier research found that GD patients?immune systems produce an antibody that other people do not. Not recognizing the patient’s thyroid as "self," the antibody mistakenly mounts an attack against the or...Investigating the measles virus as a tool to kill multiple myeloma
...cteristic of the NIS protein can be exploited as a target in cancer therapy because it can concentrate radioactive iodine, thus providing a way to selectively irradiate cancer cells, image the tumors and monitor regression. Eligible candidates for the multiple myeloma study will be adults with relapsed ......ller reports that the Tibetan antelope -- once the target of rampant poaching -- may be increasing in numbers due to a combination of better enforcement and a growing conservation ethic in local communities. The eight-week journey, which was co-funded by WCS and National Geographic, took place over a remar...