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Tag: "target" at biology news

Researchers discover inherited mutation for leukemia

... gene in the pathogenesis of CLL, and direct us to target this gene with therapies that might re-activate it." The findings also provide evidence that some genes might contribute to cancer even when they are not silenced entirely. "This inherited change is remarkably subtle," says co-principal inves...

Blood test may help signal tumor's remission, return in throat cancer patients

...hers suggest that this protein may represent a new target for drug therapy. Drugs that help turn off NF-kappaB are currently being tested in clinical trials at NIH and elsewhere. The researchers note that a few of the patients experienced elevations in cytokine levels related to other illnesses or injuri...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...d genes had been effectively incorporated into the target nerve cells. According to Dr. Glorioso, HSV delivery of GDNF or neurturin presents a potentially important new approach for the treatment of ED. "Because the herpes virus persists in the nerve cell for as long as it is alive and nerve cells typica...

Hormone helps mice 'hibernate,' survive starvation

...e” to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic dis...“Given that the PPAR-alpha receptor already is the target of drugs that work to boost high-density lipoproteins, or the ‘good’ cholesterol, and reduce the amo...

Research team identifies new Alzheimer's gene

...ings are confirmed, this discovery could provide a target for future Alzheimer’s therapeutic drugs. “We hope that this study, along with the genome-wide genetics studies to come, will contribute to the clarification of Alzheimer’s risk factors and disease mechanisms, the discovery of promising new diseas...

Newly found sensing system enables certain bacteria to resist human immune defenses

...tive bacteria, PhoP/PhoQ has been called a premier target for antimicrobial drug discovery, but little corresponding work has been done with gram-positive bacteria,” Dr. Otto says. “Our group is excited by what we have demonstrated—an efficient and unique way that gram-positive bacteria control resistance—a...

Breakthrough developments in rheumatoid arthritis reported

...e importance of a substance called citrulline as a target for immune attack in rheumatoid arthritis (RA). This immune system antibody associated with rheumatoid arthritis recognizes citrulline, which seems to be a key player in the condition. Indeed, the HLA associations with RA have now been shown by Dr. ...

U-M researchers discover gene switched off in cancer can be turned on

...r monitor cancer, currently no treatments actually target these genes. U-M researchers found that a gene ...traightforward extension of current therapies that target genes that are turned on,” says lead study author David Reisman, M.D., Ph.D., assistant professor of...

Migration alert -- How tumor cells home in on the lymphatic system

...plains. “Therapeutically, it indicates that a drug target for lymph node metastases could be blocking the signaling molecule or its receptor on the tumor cell.”...

Newly discovered antibody may be body's natural defense against Alzheimer's

...diseases. The newly found antibodies selectively target aggregates of beta amyloid proteins called "oligom... main culprit in Alzheimer's and therefore a prime target for a new generation of disease-modifying treatments. To further confirm that these natural anti...

Progress toward an antitumor vaccine

...polysaccharides. The modified MUC1 would be a good target molecule (antigen) for antibodies in immunological antitumor therapy. The difficulty with this approach is that such sugar-containing compounds are completely ineffective at stimulating the immune system to form antibodies. “Immunization is only s...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

...ting lung cancers, for example, it must be able to target a small subset of cancer stem cells, which they ha...ncer therapies have to be designed specifically to target cancer stem cells while sparing normal stem cells,” she explained. ...

Potent possibilities for parasite attack

...y new to biology, that will provide a framework to target the search for new treatments. Leishmaniasis is a ...ght be essential to each species. One potential target is the CFAS gene that codes for cyclopropane fatty acid synthase, an enzyme that may be involved in ...

How 'memory' T cells curb the spread of viruses throughout the body

... that memory CD8 T cells rapidly multiply and kill target cells inside the lymph node. “In fact we found that memory CD8 T cells already killed target cells in the lymph node and decreased viral spread to the liver and spleen when the virus just barel...

Researchers identify protein pathway involved in Parkinson disease development

...tions affect cellular function and could provide a target for drug therapies to treat the disease. The rese...elieve the PINK1 and TRAP1 pathway may be a future target for therapeutic intervention."...

New vaccine prevents CMV infection and disease in mice

...her in human or mouse viruses, and present a novel target for the host’s T-cells to muster forces and attack the virus. Secondly, the vaccine also contains a “boost” from an inactivated virus, which generates an antibody response. Neither approach alone would give complete protection. “In mice, the vac...

St. Jude study shows genes play an unexpected role in their own activation

...actor uses the same co-factors to activate all its target genes. The new findings showed that phosphate-...cessary for only part of the activation of certain target genes; those genes became activated even when KIX was disabled in CBP/p300. Further studies suggeste...

How plague-causing bacteria disarm host defense

...hool of Medicine have identified a novel molecular target for an effector protein called YpkA, one of severa...UCSD School of Medicine. Identifying this new target is the first step to developing effective strategies for preventing disease, including means to figh...

'Smart' mice teach scientists about learning process, brain disorders

...ing in the brain, which might serve in humans as a target for treating disorders such as post-traumatic stress disorder, Alzheimer’s disease or drug addiction, the researchers said. "It’s pretty rare that you make mice ‘smarter,’ so there are a lot of cognitive implications," said Dr. James Bibb, assista...

Focused ultrasound relieves fibroid symptoms in women

... surgery (MRgFUS) allows radiologists to precisely target fibroids without harming healthy surrounding tissu...re-treatment MR imaging to identify and define the target fibroids. Radiologists then used MRgFUS to locate and treat the targeted fibroids while monitoring t...

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