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Tag: "tangles" at biology news

Study examines genetic risk factors for Alzheimer's disease

... being ‘GALP?which could affect the development of tangles within brain cells, a hallmark of Alzheimer’s disease. Professor Julie Williams, School of Medicine, who leads this project with Professor Micheal Owen said: “Whilst these genes are likely to make modest contributions to disease more work needs to...

Cold sore virus might play role in Alzheimer's disease

...und the body, is associated with both the cellular tangles and amyloid plaques that are found in the brains o...r's disease, before any of the hallmark plaques or tangles and certainly long before any behavioral changes are seen. Such inflammation often is a byproduct wh...

Faster, more accurate tuberculosis test developed

...an in solid medium; (2) TB grows in characteristic tangles or coils and these characteristic cord formations can be seen microscopically in liquid medium; and (3) the ability to incorporate drugs permits rapid and direct drug-susceptibility testing at the same time as the detection of bacterial growth. Ove...

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

...s--known to develop severe deposits of plaques and tangles in AD patients. Dysfunction in acetylcholine recep...7B reduced levels of both pathological plaques and tangles in the cortex and hippocampus, but not in the amygdala. In experiments that demonstrated the centra...

Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

... can lead to the brain/mind-destroying plaques and tangles visible years later in the cortex of Alzheimer patients. The Apolipoprotein E (ApoE) genotype is the second most influential Alzheimer risk factor, after only advanced age. The study used MRI to assess myelin breakdown in 104 healthy individuals be...

New compound stops brain cell degeneration in Alzheimer's disease

...her investigators in the field has linked plaques, tangles and neuronal injury to synaptic dysfunction and cognitive decline, the direct linkage of glia to these processes and their potential as a selective target for new therapies has not previously been implicated so directly. There are three key aspects ...

U of MN researchers reverse memory loss in mice

...fter the memory loss was regained in the mice, the tangles remained, and even increased in number. This suggests that the tangles are not a cause of dementia as previously thought. The mice serve as a model that shows how the dis...

Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

...and his team chose to focus on the neurofibrillary tangles of neurons in the brain that, along with senile plaques, characterize Alzheimer's disease. The tangles are made of "tau," a protein that is also present normally in the brain. "Tau goes wrong and become...

Scientists discover that three molecules may be developed into new Alzheimer's drugs

...and his team chose to focus on the neurofibrillary tangles of neurons in the brain that, along with senile plaques, characterize Alzheimer's disease. The tangles are made of "tau," a protein that is also present normally in the brain. "Tau goes wrong and become...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...normal prion protein, which aggregate into fibrous tangles called amyloid fibrils and cause fatal wasting of brain tissue. The abnormally folded protein itself appears to act as an infectious agent, transmitting disease without a DNA or RNA genome such as in a virus. Although disease prions seem to infect no...

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