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Tag: "tamoxifen" at biology news

Selective marker found to indicate aggressive form of breast cancer

...inates several important lines of therapy, such as tamoxifen or Herceptin, that work well for other breast cancer subtypes. "Currently, there is no direct means of determining if a breast cancer is a basal epithelial tumor ?doctors only know for certain once the other forms of breast cancer are ruled out,"...

Molecular signature may identify cisplatin-sensitive breast tumors

...erone, and in recent years antiestrogen drugs like tamoxifen have improved outcomes for women with those tumors. About 20 to 30 percent of tumors, some with hormone receptors, have elevated levels of a growth-promoting protein called HER2, and those tumors are candidates for treatment with the monoclonal anti...

Adding radiation decreases breast cancer recurrence

...en also benefit from the recommended five years of tamoxifen treatment for hormone responsive tumors. Among wom...ional recurrence. These results held regardless of tamoxifen treatment, suggesting that adjuvant radiation treatment was highly effective. In addition, the r...

Turning a cellular sentinel into a cancer killer

... mice were genetically engineered so that the drug tamoxifen could be used to switch on p53 activity. "When we reactivated p53 in these mice, we saw two distinct tumor phenotypes," said Jacks. "In lymphomas the responses were rapid, extensive and were accompanied by the induction of apoptosis. In the sarcoma...

Molecular atlas provides new tool for understanding estrogen-fueled breast cancer

...ence of estrogen. Drugs that block the ER, such as tamoxifen and fulvestrant, are often able to stop or slow the growth of these estrogen-driven tumors. "For the most part, the sequence of steps between the activation of the estrogen receptor and the beginning of tumor cell division has been unclear. We've k...

Scientists discover way to block growth of prostate cancer cells

...patients can be treated with several drugs such as tamoxifen and aromatase inhibitors that prevent or delay breast cancer recurrence. No such treatment exists for prostate cancer patients. After treatment of their primary tumours, prostate cancer in men is managed by watchful observation only. The immediate...

Restoring tamoxifen sensitivity in resistant breast cancer cells

The widely used breast cancer drug tamoxifen (Nolvadex®), which can become less effective over ... recurring after surgery. Clinicians observed that tamoxifen treatment initially reduced the rate of recurrence by nearly 50 percent. Over time, however, patient...

Pak1 expression increases tamoxifen resistance in breast cancer patients

...resistance to therapeutic effects of anti-estrogen tamoxifen treatment, according to a study in the May 17 Jo...trial where they were randomly assigned to receive tamoxifen therapy or no treatment. The authors examined whether tumor levels of Pak1 were associated with the...

Tamoxifen for breast cancer prevention does not benefit most women

..., Canada. In addition, the researchers showed that tamoxifen is an extraordinarily expensive cancer-prevention ...ncer, there is a very small likelihood that taking tamoxifen will reduce mortality," said Joy Melnikow, professor of family and community medicine at UC Davis Sc...

Gene variation affects tamoxifen's benefit for breast cancer

...fects the level of a crucial enzyme that activates tamoxifen to fight breast cancer. The study, co-led by rese...as shown that CYP2D6 is responsible for activating tamoxifen to a metabolite called endoxifen that is nearly 100 times more potent as an anti-estrogen than tamox...

NIH renews network focused on how genes influence drug responses

... genetic differences explain variable responses to tamoxifen and hormone treatments frequently prescribed to treat breast cancer. (David A. Flockhart, M.D., Ph.D., Indiana University School of Medicine) The Pharmacogenetics of Membrane Transporters --$15 million provided by NIGMS, NCI, and NIMH to s...

Researchers develop promising new gene network analysis method

...itive enough to capture gene network changes after tamoxifen treatment, producing a list of 130 genes significantly altered by c-Myc activation. This method was also reliable. When researchers reshuffled the data time points, those network changes disappeared. In contrast, the gene network constructed by the ...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...r is helping researchers understand why drugs like tamoxifen and raloxifene behave the way they do, simulating ...y that differs slightly, but importantly, from how tamoxifen fits. The slight difference changes the shape of the receptor in ways that alter its effects on the ...

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