'Genetic network' guards against lethal DNA damage
...f the genes are pulled out." The dSLAM technology takes advantage of DNA barcode that identifies which genes a yeast cell is missing. This is much like using a commercial barcode in a store to quickly identify items at the checkout counter. The scanner in this case is a microarray: a grid of thousands of ...... or alpine strawberry Fragaria vesca. The method takes advantage of Agrobacterium's circular DNA molecule (T-DNA) to deliver DNA to the plant. By helping researchers establish the function of large numbers of strawberry genes, this method could, in the long term, be extremely useful in enhancing the nutr...Computer simulation hints at new HIV drug target
...ly different shapes. In real time, this contortion takes only a fraction of a second. In the end, however, ...er to prevent the enzyme from working. It probably takes more energy for the drugs to close the more mobile flaps of the mutant. Perryman and his colleagues...Major WHO study concludes calcium supplements can reduce complications during pregnancy
...ly different shapes. In real time, this contortion takes only a fraction of a second. In the end, however, ...er to prevent the enzyme from working. It probably takes more energy for the drugs to close the more mobile flaps of the mutant. Perryman and his colleagues...Scientists force viruses to evolve as better delivery vehicles for gene therapy
... is the best way to do it." Since each generation takes about a month, Schaffer predicted that many types of new and improved strains could be created in a few months' time, and certainly in less than a year. He is pursuing experiments now using pooled human blood serum. "This virus is kind of a gift fro...Study: Paramedics save more lives when they don't follow the rules
...d waiting for the defibrillator to do its analysis takes time ?time a cardiac arrest victim doesn't have," said Gordon A. Ewy, MD, director of the Sarver Heart Center and co-author of the study. "I am convinced that Cardiocerebral Resuscitation will have a world-wide impact." "In laboratory experiments, w...One in 14 men having a heart attack drive themselves to hospital
...women face much longer delays, both in the time it takes them to get to the hospital and in receiving treatment and being admitted when they arrive. "Women need to be much more aware of the risks they face from heart attacks and the importance of seeking prompt treatment." The team's previous paper, publ...Jefferson researchers building a better rabies vaccine
...--and especially in underdeveloped nations--rabies takes a large human toll; more than 60,000 deaths a year...-important outer glycoprotein, that a vaccine that takes advantage of immune reactions to this protein can be effective. Dr. Dietzschold explains that the c...BioMed Central launches Biology Direct
...published alongside each article. The journal also takes the innovative step of requiring that the author approach Biology Direct Editorial Board members directly to review the manuscript. The journal, available online at www.biology-direct.com , launches with publications in the fields of Systems Biolog...New vaccine for condition that kills 500,000 children a year
... a rate of one in 10,000 patients. Intussusception takes place when the bowel folds in on itself, causing an intestinal blockage. Because the bowel obstruction was so rare, and the increased incidence was so small, the only way to evaluate the safety of a new rotavirus vaccine was to launch a clinical tri...All placebos not created alike
...e physiological responses to placebos. A new study takes placebo investigations out of the lab and into a c...thing was administered to cause them. This study takes the first step away from examining the placebo effect as a generalized phenomenon to one investigati...FDA approves first medical device using rutgers biomaterial
...ient track to FDA approval ?a process that usually takes 10 years or more. The invention was made with initial research support from the National Institutes of Health and demonstrates how a federal agency's funding can reap benefits for the American public. On a local level, the company and the invention ...New method enables gene disruption in destructive fungal pathogen
...function in most filamentous fungi. The new method takes advantage of a novel linear DNA construct that greatly improves the efficiency of targeted gene disruption. The DNA construct includes an antibiotic-resistance marker gene, which allows for easy selection of the new mutants, as well as a short partia...VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
...m compounds. The enhanced uptake into cancer cells takes advantage of weak molecular interactions on the cells' surface. These results underscore the importance of the new compound's "non-covalent" interactions, prior to the attack on DNA. Non-covalent interactions minimize potential side reactions and pro...Landmark discovery of a Kaposi's sarcoma-associated herpesvirus receptor
...ighlights the outstanding intramural research that takes place here on the NIH campus," says Elias A. Zerhouni, M.D., NIH director. "Understanding the mechanisms of cell entry of Kaposi's sarcoma herpesvirus is a landmark achievement in and of itself," says NIAID director Anthony S. Fauci, M.D. "But the c...New 'implanted contacts' designed to fix nearsightedness
...eed be. The procedure, Dr. Bowman said, normally takes about 10 to 15 minutes, and the patient sees the improvement soon after. ...Common molecular 'signature' identified in solid tumors
...n genetic pathways that become scrambled as cancer takes hold and spreads. He says narrowing the list of the most active ones provides a guide to directing future research. "We know that there are hundreds of miRNAs, and some of them may have multiple gene targets. Finding the ones that appear over and o...Radiotherapy advance points way to noninvasive brain cancer treatment
...ls only-what's known as "the photoelectric effect" takes place. "Exactly 100 years after Einstein first explained this effect, we have found a way to make it useful in medicine," De Stasio says. "In this effect, atoms absorb photons and emit electrons. The emitted electrons are very destructive for DNA, ...A case of mistaken molecular identity
... electrical impulses sent to the brain. "Rhodopsin takes light and transforms it ?that's its function," said Levin. To demonstrate molecular mimicry in the retina, Paveto extracted rhodopsin from cow's eyes. Through a series of tests, the team showed that cow rhodopsin, which is similar to the human prot......oise into the signal being recorded. The new idea takes advantage of the electric field that drives the current perpendicular to the DNA strand to reduce the structural fluctuations of DNA while it moves through the pore, thus minimizing the noise. "If nature was very unkind, then the DNA would always fl...