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Tag: "systemic" at biology news

Yale scientists identify structure for RNA quality control

... RNA quality control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is ... RNA quality control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is known to be an autoantigen, and autoimmune disease...

Vaccine targets tumors where they live

... local tumor environment as a method for improving systemic anti-tumor immunity. This concept has been suggested in mouse models but had not established in the clinical setting. The data represent the first clinical trial to directly inject a vaccinia virus expressing the B7.1 costimulatory molecule into huma...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...in two mouse models. The AAV-1 vector was given by systemic delivery ?a single infusion into the abdominal cav...essive results achieved in their experiments using systemic gene delivery, which proved there could be significant therapeutic improvements and even be life-sav...

Vineyard weeds found to host Pierce's disease of grapes

...cterial growth in host plants. "Multiplication and systemic movement of X. fastidiosa varied among different plant species and environmental conditions, so weed species in vineyards must be evaluated on an individual basis to determine their potential contribution to Pierce's disease," Wistrom said. "Currentl...

New Lab Research May Help Those Deafened By Immune System Attack

... new findings also may be important to people with systemic autoimmune disorders such as lupus or rheumatoid a...une reaction. All eight study participants who had systemic autoimmune diseases showed signs of antibodies against IESCA. Six of them regained hearing after ste...

MIT engineers an anti-cancer smart bomb

...shrank the tumor, stopped angiogenesis and avoided systemic toxicity much better than other treatment and delivery variations. But it is patient survival and quality of life that really inspire this research, Sasisekharan said. Eighty percent of the nanocell mice survived beyond 65 days, while mice treated w...

Researchers pioneer new gene therapy technique using natural repair process

...ironment. Their lifespans are usually shortened by systemic infection, and while bone marrow transplants can be used to treat the disease, they are not always successful. "SCID is ideal for this sort of therapy because you only need to correct the defect in a small number of immune cells to fix the problem,"...

Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST)

...water. Dr. Cervia described the different types of systemic disinfection methods used and the advantages and d...es to persist," explained Dr. Cervia. "Each of the systemic methods are limited in their ability to prevent patient exposure to waterborne pathogens because the...

New strategies to reduce hospital-aquired infections

...water. Dr. Cervia described the different types of systemic disinfection methods used and the advantages and d...es to persist," explained Dr. Cervia. "Each of the systemic methods are limited in their ability to prevent patient exposure to waterborne pathogens because the...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...atic breast cancer who had not previously received systemic chemotherapy for their recurrent or metastatic disease were enrolled in this study between December 2001 and May 2004. Patients were randomized to one of the two treatment arms. One patient group received standard treatment consisting of single-agent...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

...her growth. "This is the first study to show that systemic administration of siRNA can inhibit disseminated tumor growth," said Siwen Hu, a postdoctoral fellow at Children's Hospital of Los Angeles and the University of Southern California, and one of the study's lead investigators. "We conclude that this n...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...ause septic shock (sepsis). "In sepsis, which is a systemic bacterial infection, the body expresses iNOS which generates relatively high concentrations of NO," says Dr. Hobbs. "This aids host defense by killing the invading organism, but in excessive quantities starts to lead to host-damage. In sepsis, this i...

Multi-purpose protein regulates new protein synthesis and immune cell development

...ven autoimmune diseases, like myasthenia gravis or systemic lupus erythematosus." Results from the study will be published in the Feb. 1 issue of the Journal of Clinical Investigation. Kaufman studies fundamental signaling pathways involved in the production of new proteins in the cell's endoplasmic retic...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...he body itself, as in autoimmune disorders such as systemic lupus erythematosus. When viruses activate innate B cells, the body destroys the B cells to protect against autoantibodies that could cause autoimmune disease or other harm. The second immune system category is adaptive B cell immunity, a slower res...

Scientists solve structure of key protein in innate immune response

...f drugs to help treat septic shock, an often fatal systemic bacterial infection that is triggered by LPS. "Pharmaceutical companies have tried to develop anti-septic shock agents for a long time without clear success," explains Dr. Lee. "Since LPS is an important inducer of septic shock, blocking LPS recepto...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...enes with very strong associations withthe disease systemic lupus erythematosus (SLE) have been identified bya team of scientists headed by researchers at the Department of MedicalSciences at Uppsala University. The findings are being published todayon the Web page of the highly prestigious American Journal o...

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