systemic 2 2

Tag: "systemic" at biology news

U of M researchers discover genetic key to treating deadly fungal infections

...y or organ transplantation) it can produce deadly, systemic infections, causing death in 30 to 50 percent of cases. Premature babies, whose immune systems are immature, are also at risk. Led by Judith Berman, professor of genetics, cell biology and development, university researchers have discovered that ...

Weighting cancer drugs to make them hit tumors harder

... goal was to increase the tumor dose and lower the systemic dose," said Chilkoti. "Macromolecular drug carriers are an attractive drug delivery system, because they target tumors and have limited toxicity in normal tissues." Of additional benefit, macromolecular drug carriers can be substituted for the toxic...

Big hips, big belly? It's in your genes, Joslin-led study shows

...fection to other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to recognize the body's own tissues, the authors conclude. "A fine understanding of the mechanisms ...

Epstein-Barr virus may be associated with multiple sclerosis

...fection to other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to recognize the body's own tissues, the authors conclude. "A fine understanding of the mechanisms ...

Scientists identify molecular structure of key viral protein

...and animal pathogens, causing both respiratory and systemic disease. "The development of antiviral drugs is helped by knowledge of the structure, shape and mechanism of the target molecules, which is what we can now provide for the F protein," said Theodore S. Jardetzky, professor of biochemistry, molecular...

How can we protect patients with weakened immune systems from influenza?

...n which an abnormal immune system turns on itself: systemic lupus erythematosus and Sjogren's syndrome. Core research facilities will assist all the projects in systematically measuring T cell and B cell counts and developing specialized assays. The researchers will begin enrolling patients this fall under t...

Avian influenza virus in mammals spreads beyond the site of infection to other organ systems

...rchers at Erasmus Medical Center have demonstrated systemic spread of avian influenza virus in cats infected b..."Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts," appears in the Januar...

Lack of a key enzyme dramatically increases resistance to sepsis

... bacterial pathogens, and that a deficiency allows systemic and abdominal infections to be better resolved. It's known that the presence of caspase-12 as a full length protein occurs in a small percentage of people of African descent. As a result, some of these individuals are far more susceptible to severe s...

Researchers map of genetic variations implicated in disease

...wide range of diseases, including type 1 diabetes, systemic lupus erythematosus and myasthenia gravis. The PGF...s to other diseases such as multiple sclerosis and systemic lupus erythematosus. The QBL haplotype is positively associated with Graves' disease and type 1 diab...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

...second dose of vaccine did not cause more local or systemic symptoms than the first Systemic complaints of fever, malaise, muscle aches, headaches and nausea occurred with the same frequency in all dosage groups as in the placebo group Lab tests did not reveal any clinically significant abnormalities Th...

Infection 'alarm' yields clues to immune system behavior

...ase of a pricked finger. (This is in contrast to a systemic response that triggers an immune reaction throughout the body, causing a fever. If the immune system responds too aggressively in such cases, the result may be a dangerous condition called septic shock.) The innate immune response begins when white ...

Researchers use 'trickery' to create immune response against melanoma

...ological fluid flow conditions that are present in systemic microvasculature, making their use after intravenous administration therapeutically relevant. The investigators also used high magnification microscopy and 3-D image reconstruction to study the localisation of the bioconjugates after incubation with ...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...ological fluid flow conditions that are present in systemic microvasculature, making their use after intravenous administration therapeutically relevant. The investigators also used high magnification microscopy and 3-D image reconstruction to study the localisation of the bioconjugates after incubation with ...

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects

... hepatitis C, multiple sclerosis and many types of systemic cancer, who currently benefit from interferon treatment, but sometimes find it difficult to tolerate the side effects of the high doses required. "We reasoned that if we could enhance the way interferon produces its beneficial defensive effects, th...

Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection

...f these cells may have several advantages over the systemic effects of other drugs in development." Small molecule or antibody approaches require the constant presence of antagonist in high enough concentrations to block therapeutically relevant numbers of the CCR5 protein, of which there are approximately 1...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...'t kill the cancer cells and it's like a generally systemic chemotherapy drug." Again, the LHRH-ironoxide-Hecate combination worked best in targeting and killing breast cancer cells, including metastatic cells. According to Leuschner, the approach using nanoparticles has promising applications for both ...

Life in deadly conditions

...g and testing metabolic models in the framework of systemic biological studies and in interdisciplinary co-operation with mathematicians." ...

CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts

...matically elevated CO2 concentrations when causing systemic disease. In their research, the authors identify CO2 as a physiological signal that induces the pathogenic filamentous transition in C. albicans; they also demonstrate that an ancient group of enzymes called adenylyl cyclases are the so-called chemos...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...c gene throughout the body. "Previous attempts at systemic gene therapy for muscle have not been very effective because blood vessel capillaries act much like a mosquito net, blocking the gene drugs from reaching the muscle cells. Fortunately, we found a virus that is just small and sneaky enough to get thro...

New study to explore cellular circuitry

...genomic yeast library" that allows for high-speed, systemic examination of the purpose of each protein in the yeast cell. Over the last four years, medical center researchers created a library of 6000 clones, or exact copies of the genes of the yeast cell, one clone for each known protein present in the ce...

1 2 3